Indazole, benzisoxazole, and benzisothiazole kinase inhibitors

1. A compound of formula (I)

or a therapeutically acceptable salt thereof, wherein

A is phenyl;

X is NR 9 ;

R 1 and R 2 are independently selected from the group consisting of hydrogen, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, aryl, arylalkyl, aryloxy, aryloxyalkyl, halo, haloalkoxy, haloalkyl, hydroxy, hydroxyalkoxy, hydroxyalkyl, (NR a R b )alkoxy, (NR a R b )alkenyl, (NR a R b )alkyl, (NR a R b )alkynyl, (NR a R b )carbonylalkenyl, and (NR a R b )carbonylalkyl;

R 3 and R 4 are each independently selected from the group consisting of hydrogen, alkoxy, alkoxyalkoxy, alkyl, halo, haloalkoxy, haloalkyl, and hydroxy;

R 5 is LR 6 ;

L is selected from the group consisting of (CH 2 ) m N(R 7 )C(O)N(R 8 )(CH 2 ) n and CH 2 C(O)NR 7 , wherein m is 0 and n is 0, and wherein each group is drawn with its left end attached to A;

R 6 is selected from the group consisting of hydrogen, aryl, cycloalkyl, heterocyclyl, and 1,3-benzodioxolyl wherein the 1,3-benzodioxolyl can be optionally substituted with one, two, or three substituents independently selected from the group consisting of alkenyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, alkylcarbonyl, aryl, arylalkoxy, arylalkyl, aryloxy, carboxy, cyano, cycloalkyl, halo, haloalkoxy, haloalkyl, a second heterocyclyl group, heterocyclylalkyl, hydroxy, hydroxyalkyl, nitro, —NR c R d , and (NR c R d )alkyl;

R 7 and R 8 are independently selected from the group consisting of hydrogen and alkyl;

R 9 is selected from the group consisting of hydrogen, alkenyl, alkoxyalkyl, alkyl, alkylcarbonyl, aryl, heterocyclylalkyl, hydroxyalkyl, and (NR a R b )alkyl;

R a and R b are independently selected from the group consisting of hydrogen, alkenyl, alkyl, alkylcarbonyl, alkylsulfonyl, aryl, arylalkyl, arylcarbonyl, arylsulfonyl, haloalkylsulfonyl, and cycloalkyl; and

R c and R d are independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyalkyl and heterocyclyl.

2. The compound of claim 1 of formula (II)

or a therapeutically acceptable salt thereof, wherein

R 1 and R 2 are independently selected from the group consisting of hydrogen, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, aryloxy, aryloxyalkyl, halo, haloalkoxy, haloalkyl, hydroxy, hydroxyalkoxy, hydroxyalkyl, (NR a R b )alkoxy, (NR a R b )alkenyl, (NR a R b )alkyl, (NR a R b )carbonylalkenyl, and (NR a R b )carbonylalkyl;

R 3 and R 4 are independently selected from the group consisting of hydrogen, alkoxy, alkyl, halo, haloalkoxy, haloalkyl, and hydroxy;

L is selected from the group consisting of (CH 2 ) m N(R 7 )C(O)N(R 8 )(CH 2 ) n and CH 2 C(O)NR 7 , wherein m is 0 and n is 0 , and wherein each group is drawn with its left end attached to the ring substituted with R 3 and R 4 ;

R 7 and R 8 are independently selected from the group consisting of hydrogen and alkyl;

R 9 is selected from the group consisting of hydrogen, alkenyl, alkoxyalkyl, alkyl, alkylcarbonyl, aryl, heterocyclylalkyl, hydroxyalkyl, and (NR a R b )alkyl;

R 10 and R 11 are independently selected from the group consisting of hydrogen, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, aryloxy, arylalkyl, carboxy, cyano, halo, haloalkoxy, haloalkyl, hydroxy, hydroxyalkyl, nitro, and —NR c R d ;

R a and R b are independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, arylsulfonyl, and haloalkylsulfonyl; and

R c and R d are independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl.

3. The compound of claim 2 wherein L is CH 2 C(O)NR 7 .

4. The compound of claim 3 selected from the group consisting of

2-[4-(3-amino-1H-indazol-4-yl)phenyl]-N-(3-chlorophenyl)acetamide;

2-[4-(3-amino-1H-indazol-4-yl)phenyl]-N-(4-fluoro-3-methylphenyl)acetamide;

2-[4-(3-amino-1H-indazol-4-yl)phenyl]-N-[3-(trifluoromethyl)phenyl]acetamide;

2-[4-(3-amino-1H-indazol-4-yl)phenyl]-N-(3-methylphenyl)acetamide; and

2-[4-(3-amino-1-methyl-1H-indazol-4-yl)phenyl]-N-(3-methylphenyl)acetamide.

5. The compound of claim 2 wherein L is (CH 2 ) m N(R 7 )C(O)N(R 8 )(CH 2 ) n .

6. The compound of claim 5 wherein R 7 and R 8 are hydrogen, and R 9 is selected from the group consisting of alkoxyalkyl, alkyl, alkylcarbonyl, aryl, heterocyclylalkyl, hydroxyalkyl, and (NR a R b )alkyl.

7. The compound of claim 6 selected from the group consisting of

N-[4-(3-amino-1-methyl-1H-indazol-4-yl)phenyl]-N′-(3-methylphenyl)urea;

N-[4-(3-amino-1-methyl-1H-indazol-4-yl)phenyl]-N′-phenyl urea;

N-[4-(3-amino-1-methyl-1H-indazol-4-yl)phenyl]-N′-(2-methylphenyl)urea;

N-[4-(3-amino-1-methyl-1H-indazol-4-yl)phenyl]-N′-(4-methylphenyl)urea;

N-[4-(3-amino-1-methyl-1H-indazol-4-yl)phenyl]-N′-(3-methoxyphenyl)urea;

N-[4-(3-amino-1-methyl-1H-indazol-4-yl)phenyl]-N′-(3-fluorophenyl)urea;

N-[4-(3-amino-1-methyl-1H-indazol-4-yl)phenyl]-N′-(3-chlorophenyl)urea;

N-[4-(3-amino-1-methyl-1H-indazol-4-yl)phenyl]-N′-(3-bromophenyl)urea;

N-[4-(3-amino-1-methyl-1H-indazol-4-yl)phenyl]-N′-[3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-1-methyl-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea;

N-{4-[3-amino-1-(2-hydroxyethyl)-1H-indazol-4-yl]phenyl}-N′-(3-methylphenyl)urea;

N-(4-{3-amino-1-[2-(4-morpholinyl)ethyl]-1H-indazol-4-yl}phenyl)-N′-(2-fluoro-5-methylphenyl)urea;

N-(4-{3-amino-1-[2-(4-morpholinyl)ethyl]-1H-indazol-4-yl}phenyl)-N′-(3-fluorophenyl)urea;

N-(4-{3-amino-1-[2-(4-morpholinyl)ethyl]-1H-indazol-4-yl}phenyl)-N′-(3-chlorophenyl)urea;

N-(4-{3-amino-1-[2-(4-morpholinyl)ethyl]-1H-indazol-4-yl}phenyl)-N′-[3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-1-methyl-1H-indazol-4-yl)phenyl]-N′-(3-methylphenyl)urea;

N-(4-{3-amino-1-[2-(dimethylamino)ethyl]-1H-indazol-4-yl}phenyl)-N′-(2-fluoro-5-methylphenyl)urea;

N-(4-{3-amino-1-[2-(dimethylamino)ethyl]-1H-indazol-4-yl}phenyl)-N′-(3-chlorophenyl)urea;

N-{4-[3-amino-1-(2-methoxyethyl)-1H-indazol-4-yl]phenyl}-N′-(2-fluoro-5-methylphenyl)urea;

N-[4-(1-acetyl-3-amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea; and

N-[4-(3-amino-1-phenyl-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea.

8. The compound of claim 5 wherein R 7 and R 8 are hydrogen, and R 9 is hydrogen.

9. The compound of claim 8 selected from the group consisting of

N-(4-{3-amino-7-[(dimethylamino)methyl]-1H-indazol-4-yl}phenyl)-N′-(2-fluoro-5-methylphenyl)urea;

N-(4-{3-amino-7-[(dimethylamino)methyl]-1H-indazol-4-yl}phenyl)-N′-(3-chlorophenyl)urea;

N-(4-{3-amino-7-[(dimethylamino)methyl]-1H-indazol-4-yl}phenyl)-N′-[3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-7-hydroxy-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea;

N-[4-(3-amino-7-hydroxy-1H-indazol-4-yl)phenyl]-N′-(3-fluorophenyl)urea;

N-[4-(3-amino-7-hydroxy-1H-indazol-4-yl)phenyl]-N′-(3-bromophenyl)urea;

N-[4-(3-amino-7-hydroxy-1H-indazol-4-yl)phenyl]-N′-[2-fluoro-5-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-7-hydroxy-1H-indazol-4-yl)phenyl]-N′-[4-fluoro-3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-7-hydroxy-1H-indazol-4-yl)phenyl]-N′-(3-chlorophenyl)urea;

N-[4-(3-amino-7-hydroxy-1H-indazol-4-yl)phenyl]-N′-[3-(trifluoromethyl)phenyl]urea;

N-{4-[3-amino-7-fluoro-6-(hydroxymethyl)-1H-indazol-4-yl]phenyl}-N′-(2-fluoro-5-methylphenyl)urea;

N-{4-[3-amino-7-fluoro-6-(hydroxymethyl)-1H-indazol-4-yl]phenyl}-N′-[3-(trifluoromethyl)phenyl]urea;

N-{4-[3-amino-7-fluoro-6-(hydroxymethyl)-1H-indazol-4-yl]phenyl}-N′-(3-chlorophenyl)urea;

N-{4-[3-amino-7-fluoro-6-(hydroxymethyl)-1H-indazol-4-yl]phenyl}-N′-(3-methylphenyl)urea;

N-{4-[3-amino-7-fluoro-6-(hydroxymethyl)-1H-indazol-4-yl]phenyl}-N′-(3-fluorophenyl)urea;

N-(4-{3-amino-6-[(diethylamino)methyl]-7-fluoro-1H-indazol-4-yl}phenyl)-N′-(2-fluoro-5-methylphenyl)urea;

N-(4-{3-amino-6-[(diethylamino)methyl]-7-fluoro-1H-indazol-4-yl}phenyl)-N′-[3-(trifluoromethyl)phenyl]urea;

N-(4-{3-amino-6-[(diethylamino)methyl]-7-fluoro-1H-indazol-4-yl}phenyl)-N′-(3-chlorophenyl)urea;

N-(4-{3-amino-6-[(diethylamino)methyl]-7-fluoro-1H-indazol-4-yl}phenyl)-N′-(3-methylphenyl)urea;

N-(4-{3-amino-7-[(isopropylamino)methyl]-1H-indazol-4-yl}phenyl)-N′-(2-fluoro-5-methylphenyl)urea;

N-(4-{3-amino-7-[(isopropylamino)methyl]-1H-indazol-4-yl}phenyl)-N′-(3-chlorophenyl)urea;

N-(4-{3-amino-7-[(isopropylamino)methyl]-1H-indazol-4-yl}phenyl)-N′-[3-(trifluoromethyl)phenyl]urea;

N-(4-{3-amino-7-[(isopropylamino)methyl]-1H-indazol-4-yl}phenyl)-N′-(3-methylphenyl)urea; and

N-(4-{3-amino-7-[(isopropylamino)methyl]-1H-indazol-4-yl}phenyl)-N′-(4-fluoro-3-methylphenyl)urea.

10. The compound of claim 8 selected from the group consisting of

N-[4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl]-N′-(3-bromophenyl)urea;

N-[4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl]-N′-(3-chlorophenyl)urea;

N-[4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl]-N′-[3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl]-N′-(3-methylphenyl)urea;

N-[4-(3-amino-7-bromo-1H-indazol-4-yl)phenyl]-N′-(3-methylphenyl)urea;

N-[4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea;

N-[4-(3-amino-6-bromo-1H-indazol-4-yl)phenyl]-N′-(3-methylphenyl)urea;

N-[4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl]-N′-[2-fluoro-5-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl]-N′-(4-fluorophenyl)urea;

N-[4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl]-N′-(2-fluorophenyl)urea;

N-[4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl]-N′-(3-fluoro-4-methylphenyl)urea;

N-[4-(3-amino-7-fluoro-1H-indazol-4-yl)-2-fluorophenyl]-N′-(2-fluoro-5-methylphenyl)urea;

N-[4-(3-amino-7-fluoro-1H-indazol-4-yl)-2-fluorophenyl]-N′-(3-chlorophenyl)urea;

N-[4-(3-amino-5-fluoro-1H-indazol-4-yl)phenyl]-N′-(3-bromophenyl)urea;

N-[4-(3-amino-5-fluoro-1H-indazol-4-yl)phenyl]-N′-(3-methylphenyl)urea;

N-[4-(3-amino-5-fluoro-1H-indazol-4-yl)phenyl]-N′-phenylurea;

N-[4-(3-amino-5-fluoro-1H-indazol-4-yl)phenyl]-N′-[2-fluoro-3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-5-fluoro-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea;

N-[4-(3-amino-5-fluoro-1H-indazol-4-yl)phenyl]-N′-[3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-5-fluoro-1H-indazol-4-yl)phenyl]-N′-[4-fluoro-3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-5-fluoro-1H-indazol-4-yl)phenyl]-N′-(3-chlorophenyl)urea;

N-[4-(3-amino-5-fluoro-1H-indazol-4-yl)phenyl]-N′-(4-fluoro-3-methylphenyl)urea;

N-[4-(3-amino-5-fluoro-1H-indazol-4-yl)phenyl]-N′-(3-chloro-4-fluorophenyl)urea;

N-[4-(3-amino-7-bromo-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea; and

N-[4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl]-N′-(4-bromo-3-methylphenyl)urea.

11. The compound of claim 1 wherein one of R 1 and R 2 is hydrogen and the other is selected from the group consisting of (NR a R b )carbonylalkenyl and (NR a R b )alkoxy.

12. The compound of claim 11 selected from the group consisting of

N-(4-{3-amino-7-[2-(dimethylamino)ethoxy]-1H-indazol-4-yl}phenyl)-N′-phenylurea;

N-(4-{3-amino-7-[2-(dimethylamino)ethoxy]-1H-indazol-4-yl}phenyl)-N′-3-bromophenyl)urea;

N-(4-{3-amino-7-[2-(dimethylamino)ethoxy]-1H-indazol-4-yl}phenyl)-N′-(3-methylphenyl)urea;

N-(4-{3-amino-7-[2-(dimethylamino)ethoxy]-1H-indazol-4-yl}phenyl)-N′-(3-chlorophenyl)urea;

N-(4-{3-amino-7-[2-(diethylamino)ethoxy]-1H-indazol-4-yl}phenyl)-N′-phenylurea;

N-(4-{3-amino-7-[2-(diethylamino)ethoxy]-1H-indazol-4-yl}phenyl)-N′-(3-fluorophenyl)urea;

N-(4-{3-amino-7-[2-(diethylamino)ethoxy]-1H-indazol-4-yl}phenyl)-N′-(2-fluoro-5-methylphenyl)urea;

N-(4-{3-amino-7-[2-(diethylamino)ethoxy]-1H-indazol-4-yl}phenyl)-N′-(3-methylphenyl)urea;

N-(4-{3-amino-7-[2-(diethylamino)ethoxy]-1H-indazol-4-yl}phenyl)-N′-(3-bromophenyl)urea;

N-(4-{3-amino-7-[2-(diethylamino)ethoxy]-1H-indazol-4-yl}phenyl)-N′-[2-fluoro-5-(trifluoromethyl)phenyl]urea;

N-(4-{3-amino-7-[2-(diethylamino)ethoxy]-1H-indazol-4-yl}phenyl)-N′-(3-chlorophenyl)urea;

N-(4-{3-amino-7-[2-(diethylamino)ethoxy]-1H-indazol-4-yl}phenyl)-N′-[3-(trifluoromethyl)phenyl]urea;

N-[2-({3-amino-4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenyl]-1H-indazol-7-yl}oxy)ethyl]methanesulfonamide;

N-[2-({3-amino-4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenyl]-1H-indazol-7-yl}oxy)ethyl]methanesulfonamide;

N-{2-[(3-amino-4-{4-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenyl}-1H-indazol-7-yl)oxy]ethyl}methanesulfonamide;

N-[2-({3-amino-4-[4-({[(3-chlorophenyl)amino]carbonyl}amino)phenyl]-1H-indazol-7-yl}oxy)ethyl]methanesulfonamide;

N-{2-[(3-amino-4-{4-[({[3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenyl}-1H-indazol-7-yl)oxy]ethyl}methanesulfonamide,

N-[2-({3-amino-4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenyl]-1H-indazol-7-yl}oxy)ethyl]-1,1,1-trifluoromethanesulfonamide;

N-[2-({3-amino-4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenyl]-1H-indazol-7-yl}oxy)ethyl]-1,1,1-trifluoromethanesulfonamide;

N-[2-({3-amino-4-[4-({[(3-fluorophenyl)amino]carbonyl}amino)phenyl]-1H-indazol-7-yl}oxy)ethyl]-1,1,1-trifluoromethanesulfonamide;

N-[2-({3-amino-4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenyl]-1H-indazol-7-yl}oxy)ethyl]benzenesulfonamide;

N-{2-[(3-amino-4-{4-[({[3- (trifluoromethyl)phenyl]amino}carbonyl)amino]phenyl}-1H-indazol-7-yl)oxy]ethyl}benzenesulfonamide;

N-[2-({3-amino-4-[4-({[(3-fluorophenyl)amino]carbonyl}amino)phenyl]-1H-indazol-7-yl}oxy)ethyl]benzenesulfonamide;

N-[2-({3-amino-4-[4-({[(3-chlorophenyl)amino]carbonyl}amino)phenyl]-1H-indazol-7-yl}oxy)ethyl]benzenesulfonamide;

N-[2-({3-amino-4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenyl]-1H-indazol-7-yl}oxy)ethyl]thiophene-2-sulfonamide;

N-[2-({3-amino-4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenyl]-1H-indazol-7-yl}oxy)ethyl]thiophene-2-sulfonamide;

N-(4-{3-amino-7-[3-(diethylamino)propoxy]-1H-indazol-4-yl}phenyl)-N′-(2-fluoro-5-methylphenyl)urea;

N-{4-(3-amino-7-[3-(diethylamino)propoxy]-1H-indazol-4-yl}phenyl)-N′-(3-chlorophenyl)urea;

N-(4-{3-amino-7-[3-(diethylamino)propoxy]-1H-indazol-4-yl}phenyl)-N′-[3-(trifluoromethyl)phenyl]urea;

N-(4-{3-amino-7-[3-(diethylamino)propoxy]-1H-indazol-4-yl}phenyl)-N′-(3-fluorophenyl)urea;

N-(4-{3-amino-7-[3-(dimethylamino)propoxy]-1H-indazol-4-yl}phenyl)-N′-(3-methylphenyl)urea;

N-(4-{3-amino-7-[3-(dimethylamino)propoxy]-1H-indazol-4-yl}phenyl)-N′-(2-fluoro-5-methylphenyl)urea;

N-(4-{3-amino-7-[3-(dimethylamino)propoxy]-1H-indazol-4-yl}phenyl)-N′-(3-fluorophenyl)urea;

N-(4-{3-amino-7-[3-(dimethylamino)propoxy]-1H-indazol-4-yl}phenyl)-N′-(3-chlorophenyl)urea;

N-(4-{3-amino-7-[3-(dimethylamino)propoxy]-1H-indazol-4-yl}phenyl)-N′-[3-(trifluoromethyl)phenyl]urea;

N-(4-{3-amino-7-[3-(dimethylamino)propoxy]-1H-indazol-4-yl}phenyl)-N′-(4-fluoro-3-methylphenyl)urea;

N-[2-({3-amino-4-[4-({[(3-fluorophenyl)amino]carbonyl}amino)phenyl]-1H-indazol-7-yl}oxy)ethyl]methanesulfonamide; and

N-(4-{3-amino-7-[3-(dimethylamino)propoxy]-1H-indazol-4-yl}phenyl)-N′-[4-fluoro-3-(trifluoromethyl)phenyl]urea.

13. The compound of claim 1 wherein one of R 1 and R 2 is hydrogen and the other is selected from the group consisting of alkoxy, alkoxyalkoxy, and alkyl.

14. The compound of claim 1 wherein one of R 3 and R 4 is hydrogen and the other is selected from the group consisting of alkoxyalkoxy, alkyl, halo, haloalkoxy, and hydroxy.

15. The compound of claim 14 selected from the group consisting of

N-[4-(3-amino-1H-indazol-4-yl)-2-fluorophenyl]-N′-(3-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-fluorophenyl]-N′-(3-fluorophenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-fluorophenyl]-N′-(3,5-dimethylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-fluorophenyl]-N′-(3-ethylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-fluorophenyl]-N′-(3-chloro-4-fluorophenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-fluorophenyl]-N′-(3-fluoro-4-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-fluorophenyl]-N′-(3-chlorophenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-methylphenyl]-N′-(3-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-ethylphenyl]-N′-(2-fluoro-5-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-ethylphenyl]-N′-[3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-fluorophenyl]-N′-[3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-fluorophenyl]-N′-[4-fluoro-3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-1H-indazol-4-yl)-3-fluorophenyl]-N′-(3-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-3-fluorophenyl]-N′-(2-fluoro-5-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-3-fluorophenyl]-N′-(3-chlorophenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-3-fluorophenyl]-N′-(4-fluoro-3-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-hydroxyphenyl]-N′-(2-fluoro-5-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)-2-(trifluoromethoxy)phenyl]-N′-(2-fluoro-5-methylphenyl)urea and

N-[4-(3-amino-1H-indazol-4-yl)-2-fluorophenyl]-N′-(2-fluoro-5-methylphenyl)urea.

16. The compound of claim 1 wherein R 3 and R 4 are hydrogen.

17. The compound of claim 16 selected from the group consisting of

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(3-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-3,5-dimethoxyphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-[3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(3-bromophenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(3-bromo-4-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(3-ethylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-phenylurea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(3-fluoro-4-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(2-fluorophenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(4-fluorophenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(3-fluorophenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(3-hydroxyphenyl)urea;

N-[3-(3-amino-1H-indazol-4-yl)phenyl]-N′-(3-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-[4-fluoro-3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-[2-fluoro-3-(trifluoromethyl)phenyl]urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(4-bromo-2-fluorophenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(5-fluoro-2-methylphenyl)urea;

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(4-fluoro-3-methylphenyl)urea; and

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-[2-fluoro-5-(hydroxymethyl)phenyl]urea.

18. The compound of claim 2 wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, alkoxy, alkoxyalkoxy, alkoxyalkyl, aryloxy, aryloxyalkyl, halo, haloalkoxy, haloalkyl, hydroxy, hydroxyalkoxy, hydroxyalkyl, (NR a R b )alkoxy, (NR a R b )alkenyl, (NR a R b )alkyl, (NR a R b )carbonylalkenyl, and (NR a R b )carbonylalkyl.

19. A pharmaceutical composition comprising a compound of claim 1 or a therapeutically acceptable salt thereof, in combination with a therapeutically acceptable carrier.

20. The compound of claim 8 wherein one of R 1 and R 2 is hydrogen and the other is aryloxyalkyl.

21. The compound of claim 1 selected from the group consisting of N-(4-{3-amino-7-[(4-chlorophenoxy)methyl]-1H-indazol-4-yl}phenyl)-N′-(2-fluoro-5-methylpheny)urea;

N-(4- {3-amino-7-[(4-chlorophenoxy)methyl]-1H-indazol-4-yl}phenyl)-N′-(3- chloropheny)urea;

N-(4-{3-amino-7-[(4-chlorophenoxy)methyl]-1H-indazo1-4-yl}phenyl)-N′-[3-(trifluoromethyl)phenyl]urea;

N-(4- {3-amino-7-[(4-chlorophenoxy)methyl]-1H-indazol-4-yl}phenyl)-N′-(3-methylphenyOurea; and

N-(4-{3-amino-7-[(4-chlorophenoxy)methyl]-1H-indazol-4-yl}phenyl)-N′-(4-fluoro-3-methylpheny)urea.