Granted Patent
B2
US 8,063,187 · App. 12/156,183 · Granted Nov 22, 2011
Methods and compositions for inhibiting CD32B expressing cells
Assignee:
Xencor, Inc.
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Abstract
The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.
Claims (4)
1. A variant anti-CD19 antibody comprising:
a light chain comprising an amino acid sequence of SEQ ID NO: 7; and
a heavy chain comprising an amino acid sequence of SEQ ID NO: 9.
2. A pharmaceutical composition comprising the antibody according to claim 1 , and a pharmaceutically acceptable carrier.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 19, 2008
From: CHU, SEUNG YUP; DESJARLAIS, JOHN R.; KARKI, SHER BAHADUR; LAZAR, GREGORY ALAN; MOORE, GREGORY L.; VOSTIAR, IGOR
To: XENCOR, INC.
Reel/Frame 021559/0545 →
Continuity (12)
Provisional Application
60940776
· May 30, 2007
Provisional Application
60953174
· Jul 31, 2007
Provisional Application
60970413
· Sep 6, 2007
Provisional Application
60976279
· Sep 28, 2007
Provisional Application
60990509
· Nov 27, 2007
Provisional Application
61012035
· Dec 6, 2007
Provisional Application
61013775
· Dec 14, 2007
Provisional Application
61019395
· Jan 7, 2008
Provisional Application
61032059
· Feb 27, 2008
Provisional Application
61043585
· Apr 9, 2008
Provisional Application
61046397
· Apr 18, 2008