Granted Patent
B2
US 8,088,390 · App. 11/973,468 · Granted Jan 3, 2012
Methods for the early diagnosis of ovarian cancer
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Abstract
The present invention discloses the protease stratum corneum chymotryptic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies.
Claims (1)
1. An immunogenic composition, comprising an immunogenic fragment of a stratum corneum chymotryptic enzyme protein and an adjuvant, wherein said immunogenic fragment of a stratum corneum enzyme protein is a peptide consisting of the sequence selected from the group consisting of SEQ ID Nos. 31, 32, 33, 34, 35, 36, 80, 86 and 99.
Continuity (7)