3-substituted propanamine compounds

1. A racemic or enantiomerically enriched 3-substituted propanamine compound represented by the following structural formula (I):

or a pharmaceutically acceptable salt thereof, wherein;

A is selected from the group consisting of phenyl, naphthyl, and benzodioxolyl, which can be substituted with one or more identical or different substituents selected from the group consisting of hydrogen, halogen, straight- or branched-chain alkyl of from 1 to 4 carbon atoms, straight- or branched-chain alkoxy of from 1 to 3 carbon atoms, phenyl, phenyloxy, nitro, cyano, trifluoromethyl, trifluoromethoxy, methanesulfonyl and thienyl;

R 1 and R 2 are same or different and independently selected from the group consisting of hydrogen, lower alkyl of from 1 to 4 carbon atoms, substituted or unsubstituted phenyl-C 1-4 alkyl or R1 and R2 are fused with nitrogen atom to form a cyclic group which has 4 to 7 carbon atoms;

R 3 , R 4 , R 5 and R 6 are same or different and independently selected from the group consisting of hydrogen, lower alkyl of from 1 to 4 carbon atoms and substituted or unsubstituted phenyl;

B is selected from an azole as represented by the following structural formulae (II):

2. A racemic or enantiomerically enriched 3-substituted propanamine compound in accordance with claim 1 wherein A, B, R 1 and R 2 are as defined therein and each of R 3 through R 6 is hydrogen, said compound being represented by the following structural formula (III):

3. A racemic or enantiomerically enriched 3-substituted propanamine compound in accordance with claim 1 wherein A, B are as defined therein, each of R 3 through R 6 is hydrogen and one of R 1 and R 2 is hydrogen and the other is methyl, said compound being represented by the following structural formula (XI):

4. 3-Substituted propanamine compounds in accordance with claim 2 wherein said compounds are selected from the group consisting of:

[3-(3,4-Dichloro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine

S-[3-(3,4-Dichloro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine

Dimethyl-(3-naphthalen-2-yl-3-tetrazol-2-yl-propyl)-amine

Dimethyl-[3-(5-methyl-tetrazol-2-yl)-3-naphthalen-2-yl-propyl]-amine

[3-(6-Chloro-naphthalen-2-yl)-3-tetrazol-1-yl-propyl]-dimethyl-amine

Dimethyl-[3-(4-phenoxy-phenyl)-3-tetrazol-2-yl-propyl]-amine

Dimethyl-[3-(4-phenoxy-phenyl)-3-tetrazol-1-yl-propyl]-amine

[3-(6-Chloro-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

(3-Biphenyl-3-yl-3-tetrazol-2-yl-propyl)-dimethyl-amine

[3-(4-Benzyloxy-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

(3-Biphenyl-4-yl-3-tetrazol-2-yl-propyl)-dimethyl-amine

Dimethyl-[3-naphthalen-2-yl-3-(5-phenyl-tetrazol-2-yl)-propyl]-amine

Dimethyl-[3-(6-methyl-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-amine

[3-(6-Methoxy-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(3,4-Dichloro-phenyl)-3-tetrazol-2-yl-propyl]-diethyl-amine

Dimethyl-(3-naphthalen-1-yl-3-tetrazol-2-yl-propyl)-amine

[3-(3,4-Dichloro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(3,4-Dichloro-phenyl)-3-(5-phenyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(3,4-Difluoro-phenyl)-3-tetrazol-1-yl-propyl]-dimethyl-amine

[3-(3,4-Difluoro-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(3,4-Dimethyl-phenyl)-3-tetrazol-1-yl-propyl]-dimethyl-amine

[3-(3,4-Dimethyl-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(4-Chloro-phenyl)-3-tetrazol-1-yl-propyl]-dimethyl-amine

[3-(4-Chloro-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(3-Methoxy-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(3-Methoxy-naphthalen-2-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(6-Fluoro-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(6-Fluoro-naphthalen-2-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(1,4-Dimethoxy-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(1,4-Dimethoxy-naphthalen-2-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(3,5-Dimethoxy-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(3,5-Dimethoxy-naphthalen-2-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(3,5-Dimethoxy-naphthalen-2-yl)-3-tetrazol-1-yl-propyl]-dimethyl-amine

Dimethyl-[3-(4-methyl-naphthalen-1-yl)-3-tetrazol-2-yl-propyl]-amine

Dimethyl-[3-(4-methyl-naphthalen-1-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-amine

[3-(4-Fluoro-naphthalen-1-yl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(4-Fluoro-naphthalen-1-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

(3-Benzo[1,3]dioxol-5-yl-3-tetrazol-2-yl-propyl)-dimethyl-amine

[3-Benzo[1,3]dioxol-5-yl-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-Benzo[1,3]dioxol-5-yl-3-(5-methyl-tetrazol-1-yl)-propyl]-dimethyl-amine

[3-(3,4-Dimethoxy-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

Dimethyl-[3-(1,2,3,4-tetrahydro-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-amine

[3-(3,4-Difluoro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

Dimethyl-[3-tetrazol-2-yl-3-(2,4,5-trifluoro-phenyl)-propyl]-amine

Dimethyl-[3-(5-methyl-tetrazol-2-yl)-3-(2,4,5-trifluoro-phenyl)-propyl]-amine

[3-(3-Bromo-4-fluoro-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(3-Bromo-4-fluoro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(6-Methoxy-naphthalen-2-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

Dimethyl-[3-(5-methyl-tetrazol-2-yl)-3-(4-phenoxy-phenyl)-propyl]-amine

[3-(4-Bromo-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(4-Bromo-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

Dimethyl-[3-tetrazol-2-yl-3-(4-trifluoromethyl-phenyl)-propyl]-amine

Dimethyl-[3-(5-methyl-tetrazol-2-yl)-3-(4-trifluoromethyl-phenyl)-propyl]-amine

Dimethyl-[3-tetrazol-2-yl-3-(2,3,4-trichloro-phenyl)-propyl]-amine

Dimethyl-[3-(5-methyl-tetrazol-2-yl)-3-(2,3,4-trichloro-phenyl)-propyl]-amine

[3-(3-Chloro-4-methoxy-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(3-Chloro-4-methoxy-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(4-tert-Butyl-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(2,5-Difluoro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(2,4-Dichloro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(3-Chloro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(2-Chloro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(2,5-Difluoro-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(2,4-Dichloro-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(3-Chloro-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

Dimethyl-[3-(5-methyl-tetrazol-2-yl)-3-(4-trifluoromethoxy-phenyl)-propyl]-amine

[3-(3-Bromo-4-methyl-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

Dimethyl-[3-tetrazol-2-yl-3-(4-trifluoromethoxy-phenyl)-propyl]-amine

[3-(4-Bromo-3-methyl-phenyl)-3-tetrazol-2-yl-propyl]-dimethyl-amine

[3-(4-Methanesulfonyl-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

[3-(4-Isopropyl-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-dimethyl-amine

Methyl-[3-(5-methyl-tetrazol-2-yl)-3-naphthalen-2-yl-propyl]amine

(3-Biphenyl-4-yl-3-tetrazol-2-yl-propyl)-methyl-amine

[3-(3,4-Dichloro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-(4-Chloro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(3,4-Dichloro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine

Methyl-(3-naphthalen-2-yl-3-tetrazol-2-yl-propyl)-amine

[3-(6-Chloro-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-methyl-amine

Methyl-(3-naphthalen-1-yl-3-tetrazol-2-yl-propyl)-amine

Methyl-[3-(6-methyl-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-amine

Methyl-[3-naphthalen-2-yl-3-(5-phenyl-tetrazol-2-yl)-propyl]-amine

(3S)-3-(3,4-dichlorophenyl)-N-methyl-3-(2H-tetrazol-2-yl)propan-1-amine

(3R)-3-(3,4-dichlorophenyl)-N-methyl-3-(2H-tetrazol-2-yl)propan-1-amine

(3S)-3-(3,4-dichlorophenyl)-N-methyl-3-(5-methyl-2H-tetrazol-2-yl)propan-1-amine

(3R)-3-(3,4-dichlorophenyl)-N-methyl-3-(5-methyl-2H-tetrazol-2-yl)propan-1-amine

(3R)—N-methyl-3-(2-naphthyl)-3-(2H-tetrazol-2-yl)propan-1-amine

(3S)—N-methyl-3-(2-naphthyl)-3-(2H-tetrazol-2-yl)propan-1-amine

[3-(3-Methoxy-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(3-Methoxy-naphthalen-2-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-(6-Fluoro-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(6-Fluoro-naphthalen-2-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-(1,4-Dimethoxy-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(1,4-Dimethoxy-naphthalen-2-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-(3,5-Dimethoxy-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(3,5-Dimethoxy-naphthalen-2-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-(3,5-Dimethoxy-naphthalen-2-yl)-3-tetrazol-1-yl-propyl]-methyl-amine

Methyl-[3-(4-methyl-naphthalen-1-yl)-3-tetrazol-2-yl-propyl]-amine

Methyl-[3-(4-methyl-naphthalen-1-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-amine

[3-(4-Fluoro-naphthalen-1-yl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(4-Fluoro-naphthalen-1-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

(3-Benzo[1,3]dioxol-5-yl-3-tetrazol-2-yl-propyl)-methyl-amine

[3-Benzo[1,3]dioxol-5-yl-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-Benzo[1,3]dioxol-5-yl-3-(5-methyl-tetrazol-1-yl)-propyl]-methyl-amine

[3-(3,4-Dimethoxy-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine

Methyl-[3-(1,2,3,4-tetrahydro-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-amine

[3-(3,4-Difluoro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(3,4-Difluoro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

Methyl-[3-tetrazol-2-yl-3-(2,4,5-trifluoro-phenyl)-propyl]-amine

Methyl-[3-(5-methyl-tetrazol-2-yl)-3-(2,4,5-trifluoro-phenyl)-propyl]-amine

[3-(3-Bromo-4-fluoro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(3-Bromo-4-fluoro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-(6-Methoxy-naphthalen-2-yl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(6-Methoxy-naphthalen-2-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

Methyl-[3-(4-phenoxy-phenyl)-3-tetrazol-2-yl-propyl]-amine

Methyl-[3-(5-methyl-tetrazol-2-yl)-3-(4-phenoxy-phenyl)-propyl]-amine

[3-(4-Bromo-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(4-Bromo-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

Methyl-[3-tetrazol-2-yl-3-(4-trifluoromethyl-phenyl)-propyl]-amine

Methyl-[3-(5-methyl-tetrazol-2-yl)-3-(4-trifluoromethyl-phenyl)-propyl]-amine

Methyl-[3-tetrazol-2-yl-3-(2,3,4-trichloro-phenyl)-propyl]-amine

Methyl-[3-(5-methyl-tetrazol-2-yl)-3-(2,3,4-trichloro-phenyl)-propyl]-amine

[3-(3-Chloro-4-methoxy-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(3-Chloro-4-methoxy-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-(2-Chloro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-(3-Chloro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-(2,4-Dichloro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-(2,5-Difluoro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-(3-Chloro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(2,4-Dichloro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(2,5-Difluoro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine

[3-(4-Methanesulfonyl-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

[3-(4-Isopropyl-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

(3S)-Methyl-[3-(5-methyl-tetrazol-2-yl)-3-naphthalen-2-yl-propyl]-amine

(3S)-Methyl-[3-naphthalen-2-yl-3-(5-phenyl-tetrazol-2-yl)-propyl]-amine

(3R)-Methyl-[3-(5-methyl-tetrazol-2-yl)-3-naphthalen-2-yl-propyl]-amine

(3R)-Methyl-[3-naphthalen-2-yl-3-(5-phenyl-tetrazol-2-yl)-propyl]-amine

(3R)-[3-(6-Fluoro-naphthalen-2-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine

(3S)-[3-(6-Fluoro-naphthalen-2-yl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine.

5. A compound in accordance with claim 3 wherein said compound is selected from the group consisting of:

[3-(3,4-Dichloro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine,

(R)-[3-(3,4-Dichloro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine,

(S)-[3-(3,4-Dichloro-phenyl)-3-tetrazol-2-yl-propyl]-methyl-amine,

[3-(3,4-Dichloro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine,

(R)-[3-(3,4-Dichloro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine,

(S)-[3-(3,4-Dichloro-phenyl)-3-(5-methyl-tetrazol-2-yl)-propyl]-methyl-amine,

Methyl-(3-naphthalen-2-yl-3-tetrazol-2-yl-propyl)-amine,

(R)-Methyl-(3-naphthalen-2-yl-3-tetrazol-2-yl-propyl)-amine, and

(S)-Methyl-(3-naphthalen-2-yl-3-tetrazol-2-yl-propyl)-amine.

6. A pharmaceutical composition which comprises an amount of a racemic or enantiomerically enriched compound of formula (I) in accordance with claim 1 .

7. A pharmaceutical composition which comprises an amount of a racemic or enantiomerically enriched compound of formula (III) in accordance with claim 2 .

8. A pharmaceutical composition which comprises an amount of a racemic or enantiomerically enriched compound of formula (XI) in accordance with claim 3 .