Constructs and libraries comprising antibody surrogate light chain sequences

Assignee: Sea Lane Biotechnologies LLC

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Quick Facts

Patent No.: US 8,114,967
App. No.: 12/056,151
Granted: Feb 14, 2012
Kind: B2

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Abstract

The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same.

Claims (1)

1. A polypeptide comprising amino acid residues from 1 to about 116-126 of the VpreB1 sequence of SEQ ID NO: 1, fused directly, at its C-terminus to the N-terminus of amino acid residues from about 82-93 to 209 of the λ5 sequence of SEQ ID NO: 5, conjugated to an antibody heavy chain sequence comprising a variable region to form a conjugate, wherein the conjugate specifically binds a target.

Assignments (6)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 2, 2025

From: REVOPSIS THERAPEUTICS, INC.

To: REVOPSIS HOLDINGS, LLC

Reel/Frame 072793/0855 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 8, 2024

From: BIOASSETS, LLC

To: REVOPSIS THERAPEUTICS, INC.

Reel/Frame 066055/0107 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 20, 2023

From: I2 PHARMACEUTICALS, INC.

To: BIOASSETS, LLC