Substitution derivatives of N
View Patent ↗The invention concerns novel substitution derivatives of N 6 -benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N 6 -benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.
1. A therapeutic composition containing substitution derivatives of N 6 -benzyladenosine, selected from the group comprising 6-(2-acetylbenzylamino)purine riboside, 6-(3-acetylbenzylamino)purine riboside, 6-(4-acetylbenzylamino)purine riboside, 6-(2-acetoxybenzylamino)purine riboside, 6-(3-acetoxybenzylamino)purine riboside, 6-(4-acetoxybenzylamino)purine riboside, 6-(2-sulphobenzylamino)purine riboside, 6-(3-sulphoobenzylamino)purine riboside, 6-(4-sulphobenzylamino)purine riboside, 6-(4-methylaminobenzylamino)purine riboside, 6-(4-hexylbenzylamino)purine riboside, 6-(4-hexyloxybenzylamino)purine riboside, 6-(2-formylbenzylamino)purine riboside, 6-(3-formylbenzylamino)purine riboside, 6-(4-formylbenzylamino)purine riboside, 6-(2-ethoxybenzylamino)purine riboside, 6-(3-ethoxybenzylamino)purine riboside, 6-(4-ethoxybenzylamino)purine riboside, 6-(4-ethylbenzylamino)purine riboside, 6-(4-pentylbenzylamino)purine riboside, 6-(4-pentyloxybenzylamino)purine riboside, 6-(4-phenoxybenzylamino)purine riboside, 6-(4-propylbenzylamino)purine riboside, 6-(4-propyloxybenzylamino)purine riboside, 6-(4-octylbenzylamino)purine riboside, 6-(4-octyloxybenzylamino)purine riboside, 6-(2,5-diaminobenzylamino)purine riboside, 6-(2,5-dihydroxybenzylamino)purine riboside, 6-(2,6-dihydroxybenzylamino)purine riboside, 6-(2-hydroxy-3-methoxybenzylamino)purine riboside, 6-(2-hydroxy-4-methoxybenzylamino)purine riboside, 6-(2-hydroxy-5-methoxybenzylamino)purine riboside, 6-(2-hydroxy-6-methoxybenzylamino)purine riboside, 6-(3-hydroxy-2-methoxybenzylamino)purine riboside, 6-(3-hydroxy-4-methoxybenzylamino)purine riboside, 6-(3-hydroxy-5-methoxybenzylamino)purine riboside, 6-(3-hydroxy-6-methoxybenzylamino)purine riboside, 6-(4-hydroxy-2-methoxybenzylamino)purine riboside, 6-(4-hydroxy-3-methoxybenzylamino)purine riboside, 6-(4-hydroxy-5-methoxybenzylamino)purine riboside, 6-(4-hydroxy-6-methoxybenzylamino)purine riboside, 6-(2-hydroxy-3,4-dimethoxybenzylamino)purine riboside, 6-(2-hydroxy-3,5-dimethoxybenzylamino)purine riboside, 6-(2-hydroxy-3,6-dimethoxybenzylamino)purine riboside, 6-(2-hydroxy-4,5-dimethoxybenzylamino)purine riboside, 6-(2-hydroxy-4,6-dimethoxybenzylamino)purine riboside, 6-(2-hydroxy-5,6-dimethoxybenzylamino)purine riboside, 6-(3-hydroxy-4,5-dimethoxybenzylamino)purine riboside, 6-(3-hydroxy-4,6-dimethoxybenzylamino)purine riboside, 6-(3-hydroxy-2,4-dimethoxybenzylamino)purine riboside, 6-(3-hydroxy-2,5-dimethoxybenzylamino)purine riboside, 6-(3-hydroxy-2,6-dimethoxybenzylamino)purine riboside, 6-(4-hydroxy-2,3-dimethoxybenzylamino)purine riboside, 6-(4-hydroxy-2,5-dimethoxybenzylamino)purine riboside, 6-(4-hydroxy-2,6-dimethoxybenzylamino)purine riboside, 6-(4-hydroxy-3,5-dimethoxybenzylamino)purine riboside, 6-(4-hydroxy-3,6-dimethoxybenzylamino)purine riboside, 6-(2,3-dihydroxy-4-methoxybenzylamino)purine riboside, 6-(2,3-dihydroxy-5-methoxybenzylamino)purine riboside, 6-(2,3-dihydroxy-6-methoxybenzylamino)purine riboside, 6-(2,4-dihydroxy-3-methoxybenzylamino)purine riboside, 6-(2,4-dihydroxy-5-methoxybenzylamino)purine riboside, 6-(2,4-dihydroxy-6-methoxybenzylamino)purine riboside, 6-(2,5-dihydroxy-3-methoxybenzylamino)purine riboside, 6-(2,5-dihydroxy-4-methoxybenzylamino)purine riboside, 6-(2,5-dihydroxy-6-methoxybenzylamino)purine riboside, 6-(2,6-dihydroxy-3-methoxybenzylamino)purine riboside, 6-(2,6-dihydroxy-4-methoxybenzylamino)purine riboside, 6-(2,6-dihydroxy-5-methoxybenzylamino)purine riboside, 6-(3,4-dihydroxy-2-methoxybenzylamino)purine riboside, 6-(3,4-dihydroxy-5-methoxybenzylamino)purine riboside, 6-(3,4-dihydroxy-6-methoxybenzylamino)purine riboside, 6-(3,5-dihydroxy-2-methoxybenzylamino)purine riboside, 6-(3,5-dihydroxy-4-methoxybenzylamino)purine riboside, 6-(3,5-dihydroxy-6-methoxybenzylamino)purine riboside, 6-(2-hydroxy-3,4,5-trimethoxybenzylamino)purine riboside, 6-(2-hydroxy-3,4,6-trimethoxybenzylamino)purine riboside, 6-(2-hydroxy-4,5,6-trimethoxybenzylamino)purine riboside, 6-(2,3,4-trihydroxybenzylamino)purine riboside, 6-(2,4,6-trihydroxybenzylamino)purine riboside, 6-(2,3,4-trihydroxybenzylamino)purine riboside, 6-(3,4,5-trihydroxybenzylamino)purine riboside, 6-(2,4,6-tri hydroxybenzylamino)purine riboside, 6-(2-hydroxy-3-chlorobenzylamino)purine riboside, 6-(2-hydroxy-4-chlorobenzylamino)purine riboside, 6-(2-hydroxy-5-chlorobenzylamino)purine riboside, 6-(2-hydroxy-6-chlorobenzylamino)purine riboside, 6-(2-hydroxy-3-iodobenzylamino)purine riboside, 6-(2-hydroxy-4-iodobenzylamino)purine riboside, 6-(2-hydroxy-5-iodobenzylamino)purine riboside, 6-(2-hydroxy-6-iodobenzylamino)purine riboside, 6-(2-hydroxy-3-bromobenzylamino)purine riboside, 6-(2-hydroxy-4-bromobenzylamino)purine riboside, 6-(2-hydroxy-5-bromobenzylamino)purine riboside, 6-(2-hydroxy-6-bromobenzylamino)purine riboside, 6-(2-hydroxy-3-fluorobenzylamino)purine riboside, 6-(2-hydroxy-4-fluorobenzylamino)purine riboside, 6-(2-hydroxy-5-fluorobenzylamino)purine riboside, 6-(2-hydroxy-6-fluorobenzylamino)purine riboside, 6-(2-hydroxy-3-methylbenzylamino)purine riboside, 6-(2-hydroxy-4-methylbenzylamino)purine riboside, 6-(2-hydroxy-5-methylbenzylamino)purine riboside, 6-(2-hydroxy-6-methylbenzylamino)purine riboside, 6-(2,3-dihydroxy-4-chlorobenzylamino)purine riboside, 6-(2,3-dihydroxy-5-chlorobenzylamino)purine riboside, 6-(2,5-dihydroxy-4-chlorobenzylamino)purine riboside, 6-(2,6-dihydroxy-4-chlorobenzylamino)purine riboside, 6-(2,6-dihydroxy-4-bromoxybenzylamino)purine riboside, 6-(2,6-dihydroxy-4-iodobenzylamino)purine riboside, 6-(2,6-dihydroxy-3-chlorobenzylamino)purine riboside, 6-(2,6-dihydroxy-3-bromobenzylamino)purine riboside, 6-(2,6-dihydroxy-3-iodobenzylamino)purine riboside, 6-(2,6-dihydroxy-3-fluorobenzylamino)purine riboside, 6-(2,6-dihydroxy-3,5-dichlorobenzylamino)purine riboside, 6-(2,6-dihydroxy-3,5-dibromobenzylamino)purine riboside, 6-(2,6-dihydroxy-3,5-diiodobenzylamino)purine riboside, 6-(2,6-dihydroxy-3,5-difluorobenzylamino)purine riboside, and their pharmaceutically acceptable salts with alkali metals, ammonium or amines, in the form of racemates or optically active isomers, as well as their addition salts with acids.
2. A pharmaceutical composition, containing a substitution derivative of N6-benzyladenosine according to claim 1 , or its pharmaceutically acceptable salt, including a pharmaceutical carrier.
3. A cosmetic composition, containing a substitution derivative of N6-benzyladenosine according to claim 1 , or its pharmaceutically acceptable salt, including a pharmaceutical carrier.
4. A pharmaceutical composition containing a compound according to claim 1 , including a pharmaceutical carrier, suitable as mitotic or antimitotic compound.