Solubilized CoQ-10
The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
1. A soft gelatin capsule, comprising coenzyme Q-10 solubilized in limonene to form a solution, wherein the amount of coenzyme Q-10 in said solution is about 15 percent up to about 60 percent coenzyme Q-10 by weight, with the proviso that the coenzyme Q-10 solubilized in the limonene is not in an emulsion, suspension, or elixir.
2. The soft gelatin capsule of claim 1 , wherein said coenzyme Q-10 is selected from the group consisting of coenzyme Q-10, reduced coenzyme Q-10 and semi-reduced coenzyme Q-10.
3. The soft gelatin capsule of claim 1 , wherein said coenzyme Q-10 is solubilized in said limonene in an amount of about 15 percent to about 40 percent by weight.
4. The composition of claim 1 , wherein said soft gelatin capsule further comprises rice bran oil or beeswax.
5. The composition of claim 1 , wherein said soft gelatin capsule further comprises an antioxidant.
6. The soft gelatin capsule of claim 1 , wherein said coenzyme Q-10 is solubilized in said limonene in an amount from about 20 to about 40 percent by weight.
7. The soft gelatin capsule of claim 1 , wherein said coenzyme Q-10 is solubilized in said limonene in an amount from about 15 to about 50 percent by weight.
8. The soft gelatin capsule of claim 1 , wherein said coenzyme Q-10 is solubilized in said limonene in an amount from about 20 percent to about 60 percent by weight.
9. The soft gelatin capsule of claim 1 , further comprising a carrier.
10. The soft gelatin capsule of claim 9 , wherein said carrier is an oil.
11. The soft gelatin capsule of claim 10 , wherein said oil is rice bran oil.
12. The soft gelatin capsule of claim 10 , wherein said oil is a fish oil.
13. The soft gelatin capsule of claim 10 , further comprising a tocopherol.
14. The soft gelatin capsule of claim 1 , wherein said coenzyme Q-10 is solubilized in said limonene in an amount from about 40 percent to about 60 percent by weight.
15. A packaged nutraceutical formulation comprising:
(a) coenzyme Q-10 and a sufficient quantity of limonene suitable to solubilize said coenzyme Q-10 to form a solution, wherein the amount of coenzyme Q-10 in said solution is about 15 percent up to about 60 percent coenzyme Q-10 by weight, with the proviso that the coenzyme Q-10 solubilized in the limonene is not in an emulsion, suspension, or elixir, and wherein said formulation is encapsulated in a gelatin capsule; and
(b) instructions for the use thereof.
16. The packaged nutraceutical formulation of claim 15 , wherein said coenzyme Q-10 is selected from the group consisting of coenzyme Q-10, reduced coenzyme Q-10 and semi-reduced coenzyme Q-10.
17. The packaged nutraceutical formulation of claim 15 , wherein said coenzyme Q-10 is solubilized in said limonene in an amount from about 15 to about 40 percent by weight.
18. The packaged nutraceutical formulation of claim 15 , wherein said coenzyme Q-10 is solubilized in said limonene in an amount from about 20 percent to about 45 percent by weight.
19. The packaged nutraceutical formulation of claim 15 , wherein said formulation further comprises a carrier.
20. The packaged nutraceutical formulation of claim 19 , wherein said carrier is an oil.
21. The packaged nutraceutical formulation of claim 20 , wherein said oil is rice bran oil.
22. The packaged nutraceutical formulation of claim 20 , wherein said oil is a fish oil.
23. The packaged nutraceutical formulation of claim 20 , wherein the solution further comprises a tocopherol.
24. The packaged nutraceutical formulation of claim 15 , wherein said coenzyme Q-10 is solubilized in said limonene in an amount from about 40 percent to about 60 percent by weight.