Medical devices comprising nanomaterials and therapeutic methods utilizing the same
The present invention provides medical devices comprising nanomaterials. By utilizing nanomaterials in the production thereof, the inventive medical devices can be provided with various advantageous properties and/or capabilities. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provided a method of medical care, including methods of treatment or diagnosis, wherein the inventive devices are brought into therapeutic contact with a body to be treated or diagnosed thereby.
1. An intravascular balloon catheter comprising:
an outer tubular member having a proximal end and a distal end;
an inner tubular member disposed coaxially within the outer tubular member, the inner tubular member having a proximal end and a distal end and including an inner layer, an outer layer, and an intermediate layer disposed therebetween; and
an inflatable balloon having a proximal waist and a distal waist, wherein the balloon is attached proximate the distal end of the outer tubular member at the proximal waist and the balloon is attached proximate the distal end of the inner tubular member at the distal waist;
wherein at least one of the inner or outer layers of the inner tubular member includes a nanocomposite material comprising a matrix material and a first plurality of nanoparticles comprising carbon nanotubes or carbon nanofibers; and
wherein the intermediate layer comprises a second plurality of nanoparticles.
2. The balloon catheter of claim 1 , wherein the matrix material comprises a thermoplastic or a thermoset polymer.
3. The balloon catheter of claim 1 , wherein the first plurality of nanoparticles further comprise a clay.
4. The balloon catheter of claim 3 , wherein the clay comprises montmorillonite.
5. The balloon catheter of claim 1 , wherein the first plurality of nanoparticles further comprise either octamethyl polyhedral oligomeric silsesquioxane or aminopropylisobutyl polyhedral oligomeric silsesquioxane.
6. The balloon catheter of claim 1 , wherein the nanocomposite further comprises a functionalizer.
7. The balloon catheter of claim 6 , wherein the functionalizer is alkylammonium.
8. An intravascular balloon catheter comprising:
an outer tubular member having a proximal end and a distal end;
an inner tubular member having an inner layer, an outer layer, and a tie layer disposed therebetween, the inner tubular member disposed coaxially within the outer tubular member, and the inner tubular member having a proximal end and a distal end; and
an inflatable balloon having a proximal waist and a distal waist, wherein the balloon is attached proximate the distal end of the outer tubular member at the proximal waist and the balloon is attached proximate the distal end of the inner tubular member at the distal waist;
wherein the inner layer and the outer layer of the inner tubular member each comprise a nanocomposite material; and
wherein the tie layer comprises nanoparticles, the nanoparticles comprising carbon nanotubes, ceramic nanotubes, carbon nanofibers, or ceramic nanofibers.
9. The balloon catheter of claim 8 , wherein the nanocomposite material comprises a thermoplastic or thermoset matrix material and at least one plurality of nanoparticles.
10. The balloon catheter of claim 9 , wherein the nanoparticles comprise a clay.
11. The balloon catheter of claim 9 , wherein the nanocomposite material comprises at least two pluralities of nanoparticles.
12. The balloon catheter of claim 9 , wherein the nanocomposite material further comprises a functionalizer.
13. The balloon catheter of claim 8 , wherein the inner layer and the outer layer each comprise a different nanocomposite.
14. An intravascular balloon catheter comprising:
an outer tubular member having a proximal end and a distal end;
an inner tubular member having an inner layer, an outer layer, and a tie layer disposed therebetween, the inner tubular member disposed coaxially within the outer tubular member, and the inner tubular member having a proximal end and a distal end; and
an inflatable balloon having a proximal waist and a distal waist, wherein the balloon is attached proximate the distal end of the outer tubular member at the proximal waist and the balloon is attached proximate the distal end of the inner tubular member at the distal waist;
wherein the inner tubular member includes a nanocomposite material, the nanocomposite material having a polymeric matrix material, at least one plurality of clay nanoparticles, and a functionalizer; and
wherein the tie layer comprises carbon nanotubes, ceramic nanotubes, carbon nanofibers or ceramic nanofibers.