Method of making a soft gel capsule comprising CoQ-10 solubilized in a monoterpene
The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
1. A method of preparing a soft gel capsule, comprising the steps of:
(a) mixing coenzyme Q-10 with a sufficient quantity of a monoterpene suitable to dissolve said coenzyme Q-10 and form a solution, with the proviso that said solution is not part of an emulsion, suspension, or elixir; wherein the amount of coenzyme Q-10 in said solution is about 15% up to about 60% coenzyme Q-10 by weight;
(b) mixing said solution with an acceptable carrier to form a composition, with the proviso that said composition is not an emulsion, suspension, or elixir; and
(c) encapsulating said composition in a soft gel capsule.
2. The method of claim 1 , wherein said coenzyme Q-10 is selected from the group consisting of coenzyme Q-10, reduced coenzyme Q-10 and semi-reduced coenzyme Q-10.
3. The method of claim 1 , wherein said monoterpene is limonene or a derivative thereof.
4. The method of claim 3 , wherein said limonene derivative is selected from the group consisting of perillyl alcohol, perillic acid, cis-dihydroperillic acid, trans-dihydroperillic acid, a methyl ester of perillic acid, a methyl ester of dihydroperillic acid, limonene-2-diol, uroterpenol, and a combination thereof.
5. The method of claim 1 , further comprising the step of adding rice bran oil or beeswax to the composition.
6. The method of claim 1 , wherein said coenzyme Q-10 is solubilized in said monoterpene in an amount of about 15% to about 40% by weight at room temperature.
7. The method of claim 1 , further comprising the step of adding vitamin E to the composition.
8. The method of claim 1 , further comprising the step of adding a seed oil to the composition.
9. The method of claim 1 , further comprising the step of adding a fish oil to the composition.
10. The method of claim 1 , further comprising the step of adding an antioxidant to the composition.
11. The method of claim 1 , wherein said mixing coenzyme Q-10 with a sufficient quantity of a monoterpene is at room temperature.
12. The method of claim 1 , wherein said coenzyme Q-10 is solubilized in said monoterpene in an amount of about 20% to about 40% by weight at room temperature.
13. The method of claim 1 , wherein said coenzyme Q-10 is solubilized in said monoterpene in an amount of about 15% to about 50% by weight at room temperature.
14. The method of claim 1 , wherein said coenzyme Q-10 is solubilized in said monoterpene in an amount of about 20% to about 60% by weight at room temperature.
15. The method of claim 1 , wherein said coenzyme Q-10 is solubilized in said monoterpene in an amount of about 40% to about 60% by weight at room temperature.