Effects of inhibitors of FGFR3 on gene transcription
Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in response to FGFR3 inhibition, are measured and identifications or adjustments may be made accordingly.
1. A method of identifying a patient for treatment of a cell proliferative disorder with an inhibitor of FGFR3, the method comprising:
testing a sample obtained from the patient after administration of the inhibitor to measure gene expression of at least one biomarker which is CCL3,
wherein detection of an alteration in level of expression compared to a baseline gene expression measurement of the at least one biomarker is indicative of the candidacy of the patient for the treatment, and
wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.
2. A method of identifying a patient for treatment of a cell proliferative disorder with an inhibitor of FGFR3, the method comprising:
testing a sample obtained from a patient to measure gene expression of at least one biomarker which is CCL3,
wherein detection of the presence of gene expression of the at least one biomarker is indicative of the candidacy of the patient for the treatment.
3. A method of monitoring response of a patient in need thereof to treatment for a cell proliferative disorder, the method comprising:
administering an amount of an inhibitor of FGFR3 to the patient,
testing a sample obtained from the patient after the administration of the inhibitor to measure gene expression of at least one biomarker which is CCL3,
wherein detection of an alteration in level of expression of the at least one biomarker as compared to a baseline gene expression measurement is indicative of a response of the patient to the treatment, and
wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.
4. A method of monitoring response of a patient to treatment by an inhibitor of FGFR3 for a cell proliferative disorder, the method comprising:
testing a sample obtained from the patient after administration of the inhibitor of FGFR3 to measure gene expression of at least one biomarker which is CCL3,
wherein detection of an alteration in level of expression of the at least one biomarker compared to a baseline gene expression measurement is indicative of a response of the patient to the treatment, and
wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.
5. A method of utilizing a biomarker in treatment of a cell proliferative disorder in a patient, the method comprising
testing a sample obtained from the patient after administration of an inhibitor of FGFR3 to measure gene expression of at least one biomarker which is CCL3,
wherein the patient is subsequently administered the same or a different inhibitor of FGFR3 provided alteration of the level of expression of the at least one biomarker is detected upon administration of the initial inhibitor.
6. A method of adjusting a dosage amount of an inhibitor of FGFR3 for treatment of a cell proliferative disorder in a patient, the method comprising:
monitoring gene expression of at least one biomarker which is CCL3 after the administration of an initial amount of the inhibitor, and
adjusting the amount for subsequent administration of the inhibitor to the patient based upon the level of alteration of the expression of the biomarker or biomarkers that has occurred upon administration of the initial amount.
7. A method of utilizing a biomarker to identify an FGFR3 inhibitory compound for potential treatment of multiple myeloma or to guide a decision to progress an FGFR3 inhibitory compound to further development for treatment of multiple myeloma, the method comprising:
contacting the compound with a KMS18 or KMS11 cell culture, and
testing a portion of the cell culture to measure gene expression of at least one biomarker which is CCL3,
wherein detection of an alteration in expression of the at least one biomarker compared to baseline gene expression measurement is indicative of an identification of the compound for treatment or a favorable decision to progress the compound for further development, and
wherein the baseline gene expression measurement is gene expression measured in cell culture prior to the contacting.
8. A method of selecting an appropriate inhibitor of FGFR3 to administer to a patient in need of treatment with said inhibitor, the method comprising:
testing a sample obtained from the patient after administration of an initial inhibitor of FGFR3 to measure gene expression of at least one biomarker which is CCL3,
wherein the patient is subsequently administered the initial inhibitor of FGFR3 provided alteration of the level of expression of the at least one biomarker is detected upon administration of the initial inhibitor.
9. A method of utilizing CCL3 to identify an FGFR3 inhibitory compound for potential treatment of a cell proliferative disorder, the method comprising:
contacting the compound with a cell line or tissue associated with the disorder, and
testing a portion of the cell culture or tissue after the contacting to measure gene expression of at least one biomarker which is CCL3 that has been altered compared to a baseline gene expression measurement,
wherein detection of an alteration in expression of the at least one biomarker is indicative of an identification of the compound for treatment, and
wherein the baseline gene expression measurement is the gene expression measured from the cell or tissue prior to the contacting.
10. The method of claim 1 , wherein the measurement of gene expression is made by detecting the quantity of RNA transcribed by the biomarker.
11. The method of claim 1 , wherein the measurement of gene expression is made by detecting the quantity of DNA produced from reverse transcription of an RNA transcribed by the biomarker.
12. The method of claim 1 , wherein the measurement of gene expression is made by detecting a polypeptide or protein encoded by the biomarker.
13. The method of claim 1 , wherein the at least one biomarker is operably linked to a gene chip.
14. The method of claim 1 , wherein the at least one biomarker is represented in computer readable format.
15. The method of claim 1 , wherein the testing comprises contacting the sample with a gene chip comprising CCL3.
16. The method of claim 1 , wherein the detecting step comprises comparing the gene expression level of the biomarker with a gene database.
17. The method of claim 1 , wherein the treatment comprises administration of a therapeutically effective amount of the same or a different inhibitor of FGFR3 to the patient.
18. The method of claim 1 , wherein the treatment is for a neoplastic disease.
19. The method of claim 1 , wherein the treatment is for multiple myeloma.
20. The method of claim 1 , wherein the treatment is for t(4; 14) multiple myeloma.
21. The method of claim 1 , wherein the inhibitor is selected from the group consisting of CHIR-258, SU-5402, and PD-173074.
22. The method of claim 1 , wherein the inhibitor is CHIR-258.
23. The method of claim 1 , wherein the at least one biomarker further comprises a biomarker selected from the group consisting of LOC150271, CD48, DUSP4, and ITGB7.
24. The method of claim 1 , further comprising establishing a baseline gene expression measurement level for the patient prior to administering the FGFR3 inhibitor.
25. The method of claim 1 , wherein the biomarker is not any or all of CCL3, DUSP6, ANXA9, CR2, AL531683, ZNF589, AW274468, FRMD3, LTB, and WDR42A.
26. The method of claim 3 , wherein the administration is repeated before the step of testing a sample obtained from the patient.
27. The method of claim 3 , wherein the inhibitor of FGFR3 is administered in a therapeutically effective amount.
28. The method of claim 5 , wherein the initial inhibitor and the subsequently administered inhibitor are each selected from the group consisting of CHIR-258, SU-5402, and PD-173074.
29. The method of claim 5 , wherein the initial inhibitor is CHIR-258.
30. The method of claim 5 , wherein the subsequently administered inhibitor is CHIR-258.
31. The method of claim 6 , wherein the monitoring comprises contacting the sample with a gene chip comprising CCL3 and comparing the gene expression level of CCL3 with a gene database.
32. The method of any one of claims 1 - 5 or 6 - 9 , wherein the at least one biomarker further comprises one or more biomarkers selected Table I.
TABLE I
ENTREZ GENE ID
GENE SYMBOL
GENE DESCRIPTION
200734
SPRED2
sprouty-related, EVH1 domain containing 2
117854
TRIM6
tripartite motif-containing 6
1846
DUSP4
dual specificity phosphatase 4
894
CCND2
cyclin D2
6241
RRM2
ribonucleotide reductase M2 polypeptide
4821
NKX2-2
NK2 transcription factor related, locus 2 ( Drosophila )
3037
HAS2
hyaluronan synthase 2
990
CDC6
CDC6 cell division cycle 6 homolog ( S. cerevisiae )
57405
SPBC25
spindle pole body component 25 homolog ( S. cerevisiae )
934
CD24
CD24 antigen (small cell lung carcinoma cluster 4 antigen)
55165
C10orf3
chromosome 10 open reading frame 3
55388
MCM10
MCM10 minichromosome maintenance deficient 10 ( S. cerevisiae )
79019
C22orf18
chromosome 22 open reading frame 18
9768
KIAA0101
KIAA0101
51659
Pfs2
DNA replication complex GINS protein PSF2
4605
MYBL2
v-myb myeloblastosis viral oncogene homolog (avian)-like 2
161742
SPRED1
sprouty-related, EVH1 domain containing 1
4175
MCM6
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe ) ( S. cerevisiae )
11130
ZWINT
ZW10 interactor
26298
EHF
ets homologous factor
7117
TMSL3
thymosin-like 3
890
CCNA2
cyclin A2
79075
DCC1
defective in sister chromatid cohesion homolog 1 ( S. cerevisiae )
83879
CDCA7
cell division cycle associated 7
22873
DZIP1
DAZ interacting protein 1
51514
DTL
denticleless homolog ( Drosophila )
55789
DEPDC1B
DEP domain containing 1B
55355
DKFZp762E1312
hypothetical protein DKFZp762E1312
10052
GJA7
gap junction protein, alpha 7, 45kDa (connexin 45)
146909
LOC146909
hypothetical protein LOC146909
113130
CDCA5
cell division cycle associated 5
1017
CDK2
cyclin-dependent kinase 2
4176
MCM7
MCM7 minichromosome maintenance deficient 7 ( S. cerevisiae )
81610
C20orf129
chromosome 20 open reading frame 129
9833
MELK
maternal embryonic leucine zipper kinase
29128
UHRF1
ubiquitin-like, containing PHD and RING finger domains, 1
4171
MCM2
MCM2 minichromosome maintenance deficient 2, mitotin ( S. cerevisiae )
79801
SHCBP1
SHC SH2-domain binding protein 1
28231
SLCO4A1
solute carrier organic anion transporter family, member 4A1
113115
FAM54A
family with sequence similarity 54, member A
22974
TPX2
TPX2, microtubule-associated protein homolog ( Xenopus laevis )
9232
PTTG1
pituitary tumor-transforming 1
137392
LOC137392
similar to CG6405 gene product
195828
ZNF367
zinc finger protein 367
4288
MKI67
antigen identified by monoclonal antibody Ki-67
701
BUB1B
BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)
9928
KIF14
kinesin family member 14
3832
KIF11
kinesin family member 11
11065
UBE2C
ubiquitin-conjugating enzyme E2C
9837
PSF1
DNA replication complex GINS protein PSF1
387103
C6orf173
chromosome 6 open reading frame 173
1870
E2F2
E2F transcription factor 2
79733
E2F8
E2F transcription factor 8
991
CDC20
CDC20 cell division cycle 20 homolog ( S. cerevisiae )
3014
H2AFX
H2A histone family, member X
10112
KIF20A
kinesin family member 20A
993
CDC25A
cell division cycle 25A
24137
KIF4A
kinesin family member 4A
80144
FRAS1
Fraser syndrome 1
55010
FLJ20641
hypothetical protein FLJ20641
9319
TRIP13
thyroid hormone receptor interactor 13
9355
LHX2
LIM homeobox 2
7153
TOP2A
topoisomerase (DNA) II alpha 170kDa
4174
MCM5
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 ( S. cerevisiae )
55215
FLJ10719
hypothetical protein FLJ10719
11013
TMSL8
thymosin-like 8
5983
RFC3
replication factor C (activator 1) 3, 38kDa
1063
CENPF
centromere protein F, 350/400ka (mitosin)
3683
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1;
alpha polypeptide)
2237
FEN1
flap structure-specific endonuclease 1
27338
UBE2S
ubiquitin-conjugating enzyme E2S
4001
LMNB1
lamin B1
29089
UBE2T
ubiquitin-conjugating enzyme E2T (putative)
55839
BM039
uncharacterized bone marrow protein BM039
2115
ETV1
ets variant gene 1
440279
UNC13C
unc-13 homolog C ( C. elegans )
962
CD48
CD48 antigen (B-cell membrane protein)
54910
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain
(TM) and short cytoplasmic domain, (semaphorin) 4C
1902
EDG2
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
64946
CENPH
centromere protein H
157570
ESCO2
establishment of cohesion 1 homolog 2 ( S. cerevisiae )
389835
FAM72A
family with sequence similarity 72, member A
144455
E2F7
E2F transcription factor 7
51512
GTSE1
G-2 and S-phase expressed 1
7298
TYMS
thymidylate synthetase
7374
UNG
uracil-DNA glycosylase
5578
PRKCA
protein kinase C, alpha
672
BRCA1
breast cancer 1, early onset
84952
CGNL1
cingulin-like 1
10252
SPRY1
sprouty homolog 1, antagonist of FGF signaling ( Drosophila )
79682
MLF1IP
MLF1 interacting protein
8851
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
10635
RAD51AP1
RAD51 associated protein 1
22998
KIAA1102
KIAA1102 protein
148203
LOC148203
hypothetical protein LOC148203
7465
WEE1
WEE1 homolog ( S. pombe )
83540
CDCA1
cell division cycle associated 1
3070
HELLS
helicase, lymphoid-specific
891
CCNB1
cyclin B1
6790
STK6
serine/threonine kinase 6
56992
KIF15
kinesin family member 15
7112
TMPO
thymopoietin
63901
FLJ22794
FLJ22794 protein
9493
KIF23
kinesin family member 23
9133
CCNB2
cyclin B2
4173
MCM4
MCM4 minichromosome maintenance deficient 4 ( S. cerevisiae )
7083
TK1
thymidine kinase 1, soluble
983
CDC2
cell division cycle 2, G1 to S and G2 to M
11339
OIP5
Opa interacting protein 5
51203
NUSAP1
nucleolar and spindle associated protein 1
5111
PCNA
proliferating cell nuclear antigen
11004
KIF2C
kinesin family member 2C
54443
ANLN
anillin, actin binding protein (scraps homolog, Drosophila )
83461
CDCA3
cell division cycle associated 3
4085
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)
9201
DCAMKL1
doublecortin and CaM kinase-like 1
1111
CHEK1
CHK1 checkpoint homolog ( S. pombe )
9055
PRC1
protein regulator of cytokinesis 1
7804
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
4915
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
28951
TRIB2
tribbles homolog 2 ( Drosophila )
4281
MID1
midline 1 (Opitz/BBB syndrome)
3148
HMGB2
high-mobility group box 2
3161
HMMR
hyaluronan-mediated motility receptor (RHAMM)
10276
NET1
neuroepithelial cell transforming gene 1
29028
ATAD2
ATPase family, AAA domain containing 2
1062
CENPE
centromere protein E, 312kDa
1491
CTH
cystathionase (cystathionine gamma-lyase)
10615
SPAG5
sperm associated antigen 5
64581
CLEC7A
C-type lectin domain family 7, member A
10592
SMC2L1
SMC2 structural maintenance of chromosomes 2-like 1 (yeast)
332
BIRC5
baculoviral IAP repeat-containing 5 (survivin)
4172
MCM3
MCM3 minichromosome maintenance deficient 3 ( S. cerevisiae )
64105
FKSG14
leucine zipper protein FKSG14
64151
HCAP-G
chromosome condensation protein G
1163
CKS1B
CDC28 protein kinase regulatory subunit 1B
122769
PPIL5
peptidylprolyl isomerase (cyclophilin)-like 5
3398
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
22822
PHLDA1
pleckstrin homology-like domain, family A, member 1
1718
DHCR24
24-dehydrocholesterol reductase
145482
ZADH1
zinc binding alcohol dehydrogenase, domain containing 1
1847
DUSP5
dual specificity phosphatase 5
26271
FBXO5
F-box protein 5
9212
AURKB
aurora kinase B
29968
PSAT1
phosphoserine aminotransferase 1
26147
PHF19
PHD finger protein 19
55635
DEPDC1
DEP domain containing 1
10403
KNTC2
kinetochore associated 2
64081
MAWBP
MAWD binding protein
84858
ZNF503
zinc finger protein 503
55723
ASF1B
ASF1 anti-silencing function 1 homolog B ( S. cerevisiae )
7272
TTK
TTK protein kinase
9535
GMFG
glia maturation factor, gamma
1058
CENPA
centromere protein A, 17kDa
84515
MCM8
MCM8 minichromosome maintenance deficient 8 ( S. cerevisiae )
54069
C21orf45
chromosome 21 open reading frame 45
5984
RFC4
replication factor C (activator 1) 4, 37kDa
389831
LOC389831
hypothetical gene supported by AL713796
157313
CDCA2
cell division cycle associated 2
29127
RACGAP1
Rac GTPase activating protein 1
55872
PBK
PDZ binding kinase
4678
NASP
nuclear autoantigenic sperm protein (histone-binding)
7171
TPM4
tropomyosin 4
7443
VRK1
vaccinia related kinase 1
699
BUB1
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)
3925
STMN1
stathmin 1/oncoprotein 18
865
CBFB
core-binding factor, beta subunit
399664
RKHD1
ring finger and KH domain containing 1
11168
PSIP1
PC4 and SFRS1 interacting protein 1
84057
GAJ
GAJ protein
57082
CASC5
cancer susceptibility candidate 5
23286
KIBRA
KIBRA protein
285513
LOC285513
hypothetical protein LOC285513
259266
ASPM
asp (abnormal spindle)-like, microcephaly associated ( Drosophila )
150468
FLJ40629
hypothetical protein FLJ40629
6659
SOX4
SRY (sex determining region Y)-box 4
51053
GMNN
geminin, DNA replication inhibitor
3159
HMGA1
high mobility group AT-hook 1
81620
CDT1
DNA replication factor
11332
BACH
brain acyl-CoA hydrolase
4751
NEK2
NIMA (never in mitosis gene a)-related kinase 2
1033
CDKN3
cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)
8864
PER2
period homolog 2 ( Drosophila )
3418
IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
63979
FIGNL1
fidgetin-like 1
55646
LYAR
hypothetical protein FLJ20425
91614
LOC91614
novel 58.3 KDA protein
8630
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6
1038
CDR1
cerebellar degeneration-related protein 1, 34kDa
6941
TCF19
transcription factor 19 (SC1)
256435S
T6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide
alpha-2,6-sialyltransferase 3
54892
LUZP5
leucine zipper protein 5
4603
MYBL1
v-myb myeloblastosis viral oncogene homolog (avian)-like 1
1719
DHFR
dihydrofolate reductase
170954
KIAA1949
KIAA1949
7903
ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
9787
DLG7
discs, large homolog 7 ( Drosophila )
56935
FN5
FN5 protein
3015
H2AFZ
H2A histone family, member Z
10189
THOC4
THO complex 4
494143
LOC494143
similar to RIKEN cDNA 2510006C20 gene
6240
RRM1
ribonucleotide reductase M1 polypeptide
1894
ECT2
epithelial cell transforming sequence 2 oncogene
7913
DEK
DEK oncogene (DNA binding)
2146
EZH2
enhancer of zeste homolog 2 ( Drosophila )
55055
FLJ10036
Zwilch
11073
TOPBP1
topoisomerase (DNA) II binding protein 1
55502
HES6
hairy and enhancer of split 6 ( Drosophila )
55247
NEIL3
nei endonuclease VIII-like 3 ( E. coli )
54885
FLJ20298
FLJ20298 protein
83641
C10orf45
chromosome 10 open reading frame 45
64919
BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
26095
PTPN20
protein tyrosine phosphatase, non-receptor type 20
23590
TPRT
trans-prenyltransferase
387882
LOC387882
hypothetical protein
51232
CRIM1
cysteine-rich motor neuron 1
801
CALM1
calmodulin 1 (phosphorylase kinase, delta)
55964
SEPT3
septin 3
493861
EID3
E1A-like inhibitor of differentiation 3
29980
DONSON
downstream neighbor of SON
147138
EVER2
epidermodysplasia verruciformis 2
80150
ASRGL1
asparaginase like 1
5985
RFC5
replication factor C (activator 1) 5, 36.5kDa
51155
HN1
hematological and neurological expressed 1
7004
TEAD4
TEA domain family member 4
4325
MMP16
matrix metalloproteinase 16 (membrane-inserted)
203068
TUBB
tubulin, beta polypeptide
4602
MYB
v-myb myeloblastosis viral oncogene homolog (avian)
55706
TMEM48
transmembrane protein 48
348235
FAM33A
family with sequence similarity 33, member A
8871
SYNJ2
synaptojanin 2
81563
C1orf21
chromosome 1 open reading frame 21
51192
CKLF
chemokine-like factor
2326
FMO1
flavin containing monooxygenase 1
91057
NY-REN-41
NY-REN-41 antigen
10376
K-ALPHA-1
tubulin, alpha, ubiquitous
23234
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9
5982
RFC2
replication factor C (activator 1) 2, 40kDa
51063
FAM26B
family with sequence similarity 26, member B
9953
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
79723
SUV39H2
suppressor of variegation 3-9 homolog 2 ( Drosophila )
79596
C13orf7
chromosome 13 open reading frame 7
23165
NUP205
nucleoporin 205kDa
9530
BAG4
BCL2-associated athanogene 4
3146
HMGB1
high-mobility group box 1
445815
PALM2-AKAP2
PALM2-AKAP2 protein
5557
PRIM1
primase, polypeptide 1, 49kDa
2983
GUCY1B3
guanylate cyclase 1, soluble, beta 3
51776
ZAK
sterile alpha motif and leucine zipper containing kinase AZK
10926
ASK
activator of S phase kinase
8833
GMPS
guanine monphosphate synthetase
84930
MASTL
microtubule associated serine/threonine kinase-like
90417
C15orf23
chromosome 15 open reading frame 23
8530
CST7
cystatin F (leukocystatin)
9532
BAG2
BCL2-associated athanogene 2
23310
hCAP-D3
KIAA0056 protein
283991
MGC29814
hypothetical protein MGC29814
91607
FLJ34922
hypothetical protein FLJ34922
7398
USP1
ubiquitin specific protease 1
2669
GEM
GTP binding protein overexpressed in skeletal muscle
151246
SGOL2
shugoshin-like 2 ( S. pombe )
23421
ITGB3BP
integrin beta 3 binding protein (beta3-endonexin)
84969
C20orf100
chromosome 20 open reading frame 100
201725
LOC201725
hypothetical protein LOC201725
5361
PLXNA1
plexin A1
3708
ITPR1
inositol 1,4,5-triphosphate receptor, type 1
55740
ENAH
enabled homolog ( Drosophila )
126731
C1orf96
chromosome 1 open reading frame 96
57037
ANKMY2
ankyrin repeat and MYND domain containing 2
23331
KIAA1043
KIAA1043 protein
3930
LBR
lamin B receptor
3838
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
1230
CCR1
chemokine (C-C motif) receptor 1
2200
FBN1
fibrillin 1 (Marfan syndrome)
6867
TACC1
transforming, acidic coiled-coil containing protein 1
27115
PDE7B
phosphodiesterase 7B
11151
CORO1A
coronin, actin binding protein, 1A
6385
SDC4
syndecan 4 (amphiglycan, ryudocan)
3182
HNRPAB
heterogeneous nuclear ribonucleoprotein A/B
5757
PTMA
prothymosin, alpha (gene sequence 28)
83990
BRIP1
BRCA1 interacting protein C-terminal helicase 1
9830
TRIM14
tripartite motif-containing 14
57761
TRIB3
tribbles homolog 3 ( Drosophila )
2026
ENO2
enolase 2 (gamma, neuronal)
8727
CTNNAL1
catenin (cadherin-associated protein), alpha-like 1
5880
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
864
RUNX3
runt-related transcription factor 3
10950
BTG3
BTG family, member 3
81539
SLC38A1
solute carrier family 38, member 1
26051
PPP1R16B
protein phosphatase 1, regulatory (inhibitor) subunit 16B
5793
PTPRG
protein tyrosine phosphatase, receptor type, G
2767
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
55013
FLJ20647
hypothetical protein FLJ20647
4885
NPTX2
neuronal pentraxin II
79710
MORC4
MORC family CW-type zinc finger 4
490
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
2956
MSH6
mutS homolog 6 ( E. coli )
6611
SMS
spermine synthase
6627
SNRPA1
small nuclear ribonucleoprotein polypeptide A'
1434
CSE1L
CSE1 chromosome segregation 1-like (yeast)
7371
UCK2
uridine-cytidine kinase 2
7277
TUBA1
tubulin, alpha 1 (testis specific)
1786
DNMT1
DNA (cytosine-5-)-methyltransferase 1
54801
FAM29A
family with sequence similarity 29, member A
54908
FLJ20364
hypothetical protein FLJ20364
119467
MGC32871
hypothetical protein MGC32871
90390
THRAP6
thyroid hormone receptor associated protein 6
60468
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
6510
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
6628
SNRPB
small nuclear ribonucleoprotein polypeptides B and B1
205
AK3L1
adenylate kinase 3-like 1
116832
RPL39L
ribosomal protein L39-like
79902
PCNT1
pericentrin 1
54962
FLJ20516
timeless-interacting protein
23279
NUP160
nucleoporin 160kDa
23046
KIF21B
kinesin family member 21B
2288
FKBP4
FK506 binding protein 4, 59kDa
5698
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2)
10160
FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
8502
PKP4
plakophilin 4
10675
CSPG5
chondroitin sulfate proteoglycan 5 (neuroglycan C)
29899
GPSM2
G-protein signalling modulator 2 (AGS3-like, C. elegans )
10602
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
8243
SMC1L1
SMC1 structural maintenance of chromosomes 1-like 1 (yeast)
6347
CCL2
chemokine (C-C motif) ligand 2
5932
RBBP8
retinoblastoma binding protein 8
6877
TAF5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
10801
SEPT9
septin 9
55536
CDCA7L
cell division cycle associated 7-like
11340
EXOSC8
exosome component 8
5873
RAB27A
RAB27A, member RAS oncogene family
53354
PANK1
pantothenate kinase 1
2534
FYN
FYN oncogene related to SRC, FGR, YES
55166
C6orf139
chromosome 6 open reading frame 139
27346
MAC30
hypothetical protein MAC30
79037
MGC2463
hypothetical protein MGC2463
116496
C1orf24
chromosome 1 open reading frame 24
84314
MGC10744
hypothetical protein MGC10744
23531
MMD
monocyte to macrophage differentiation-associated
6558
SLC12A2
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
64282
PAPD5
PAP associated domain containing 5
55636
CHD7
chromodomain helicase DNA binding protein 7
55026
FLJ20716
hypothetical protein FLJ20716
22929
SEPHS1
selenophosphate synthetase 1
10541
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
79621
FLJ11712
hypothetical protein FLJ11712
6432
SFRS7
splicing factor, arginine/serine-rich 7, 35kDa
5214
PFKP
phosphofructokinase, platelet
26031
OSBPL3
oxysterol binding protein-like 3
1102
RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain
containing protein 2
6929
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
6632
SNRPD1
small nuclear ribonucleoprotein D1 polypeptide 16kDa
2047
EPHB1
EPH receptor B1
5168
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
55257
C20orf20
chromosome 20 open reading frame 20
81611
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
23246
BOP1
block of proliferation 1
23526
HA-1
minor histocompatibility antigen HA-1
84250
ANKRD32
ankyrin repeat domain 32
6999
TDO2
tryptophan 2,3-dioxygenase
8317
CDC7
CDC7 cell division cycle 7 ( S. cerevisiae )
55752
SEPT11
septin 11
39
ACAT2
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)
54830
FLJ20130
hypothetical protein FLJ20130
83732
RIOK1
RIO kinase 1 (yeast)
10808
HSPH1
heat shock 105kDa/110kDa protein 1
489
ATP2A3
ATPase, Ca++ transporting, ubiquitous
3251
HPRT1
hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)
10051
SMC4L1
SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
55816
DOK5
docking protein 5
3676
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
8819
SAP30
sin3-associated polypeptide, 30kDa
4436
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 ( E. coli )
10212
DDX39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
5889
RAD51C
RAD51 homolog C (S. cerevisiae)
134111
FLJ25076
similar to CG4502-PA
51377
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
6657
SOX2
SRY (sex determining region Y)-box 2
241
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
79888
FLJ12443
hypothetical protein FLJ12443
1368
CPM
carboxypeptidase M
397
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
3336
HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
2104
ESRRG
estrogen-related receptor gamma
2171
FABP5
fatty acid binding protein 5 (psoriasis-associated)
6574
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
2743
GLRB
glycine receptor, beta
1019
CDK4
cyclin-dependent kinase 4
9295
SFRS11
splicing factor, arginine/serine-rich 11
56952
PRTFDC1
phosphoribosyl transferase domain containing 1
6472
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
23512
SUZ12
suppressor of zeste 12 homolog ( Drosophila )
586
BCAT1
branched chain aminotransferase 1, cytosolic
8836
GGH
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
10383
TUBB2
tubulin, beta, 2
54101
RIPK4
receptor-interacting serine-threonine kinase 4
130271
PLEKHH2
pleckstrin homology domain containing, family H (with MyTH4 domain)
member 2
129401
NUP35
nucleoporin 35kDa
10128
LRPPRC
leucine-rich PPR-motif containing
51703
ACSL5
acyl-CoA synthetase long-chain family member 5
9448
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
79017
C7orf24
chromosome 7 open reading frame 24
262
AMD1
adenosylmethionine decarboxylase 1
960
CD44
CD44 antigen (homing function and Indian blood group system)
81930
KIF18A
kinesin family member 18A
64116
SLC39A8
solute carrier family 39 (zinc transporter), member 8
26586
CKAP2
cytoskeleton associated protein 2
51144
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12
51002
CGI-121
CGI-121 protein
9126
CSPG6
chondroitin sulfate proteoglycan 6 (bamacan)
79154
MGC4172
short-chain dehydrogenase/reductase
11096
ADAMTS5
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin
type 1 motif, 5 (aggrecanase-2)
84803
MGC11324
hypothetical protein MGC11324
4082
MARCKS
myristoylated alanine-rich protein kinase C substrate
4086
SMAD1
SMAD, mothers against DPP homolog 1 ( Drosophila )
9446
GSTO1
glutathione S-transferase omega 1
23636
NUP62
nucleoporin 62kDa
81839
VANGL1
vang-like 1 (van gogh, Drosophila )
3149
HMGB3
high-mobility group box 3
79023
NUP37
nucleoporin 37kDa
10606
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole
succinocarboxamide synthetase
10492
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
3320
HSPCA
heat shock 90kDa protein 1, alpha
6119
RPA3
replication protein A3, 14kDa
55352
HSA272196
hypothetical protein, clone 2746033
9759
HDAC4
histone deacetylase 4
5725
PTBP1
polypyrimidine tract binding protein 1
2119
ETV5
ets variant gene 5 (ets-related molecule)
10019
LNK
lymphocyte adaptor protein
9734
HDAC9
histone deacetylase 9
5885
RAD21
RAD21 homolog ( S. pombe )
79930
DOK3
docking protein 3
22837
COBLL1
COBL-like 1
339448
LOC339448
hypothetical protein LOC339448
11051
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type motif 21
9735
KNTC1
kinetochore associated 1
4148
MATN3
matrilin 3
4200
ME2
malic enzyme 2, NAD(+)-dependent, mitochondrial
26084
SGEF
Src homology 3 domain-containing guanine nucleotide exchange factor
27101
CACYBP
calcyclin binding protein
23012
STK38L
serine/threonine kinase 38 like
54566
EPB41L4B
erythrocyte membrane protein band 4.1 like 4B
6566
SLC16A1
solute carrier family 16 (monocarboxylic acid transporters), member 1
54947
FLJ20481
hypothetical protein FLJ20481
255488
IBRDC2
IBR domain containing 2
2289
FKBP5
FK506 binding protein 5
5036
PA2G4
proliferation-associated 2G4, 38kDa
4869
NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
10384
BTN3A3
butyrophilin, subfamily 3, member A3
10785
WDR4
WD repeat domain 4
3099
HK2
hexokinase 2
56121
PCDHB15
protocadherin beta 15
10155
TRIM28
tripartite motif-containing 28
6340
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
25804
LSM4
LSM4 homolog, U6 small nuclear RNA associated ( S. cerevisiae )
3939
LDHA
lactate dehydrogenase A
57552
AADACL1
arylacetamide deacetylase-like 1
9184
BUB3
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
657
BMPR1A
bone morphogenetic protein receptor, type IA
5631
PRPS1
phosphoribosyl pyrophosphate synthetase 1
204
AK2
adenylate kinase 2
55270
NUDT15
nudix (nucleoside diphosphate linked moiety X)-type motif 15
10265
IRX5
iroquois homeobox protein 5
4640
MYO1A
myosin IA
79180
EFHD2
EF hand domain family, member D2
4076
M11S1
membrane component, chromosome 11, surface marker 1
55276
PGM2
phosphoglucomutase 2
83857
ARG99
ARG99 protein
116448
OLIG1
oligodendrocyte transcription factor 1
5696
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional
protease 7)
1407
CRY1
cryptochrome 1 (photolyase-like)
11177
BAZ1A
bromodomain adjacent to zinc finger domain, 1A
51015
ISOC1
isochorismatase domain containing 1
1789
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
22948
CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
158563
LOC158563
hypothetical protein LOC158563
89891
WDR34
WD repeat domain 34
119
ADD2
adducin 2 (beta)
5358
PLS3
plastin 3 (T isoform)
7086
TKT
transketolase (Wernicke-Korsakoff syndrome)
51174
TUBD1
tubulin, delta 1
23255
KIAA0802
KIAA0802
54149
C21orf91
chromosome 21 open reading frame 91
2271
FH
fumarate hydratase
55076
TMEM45A
transmembrane protein 45A
10436
C2F
C2f protein
8553
BHLHB2
basic helix-loop-helix domain containing, class B, 2
10409
BASP1
brain abundant, membrane attached signal protein 1
22856
CHSY1
carbohydrate (chondroitin) synthase 1
84451
KIAA1804
mixed lineage kinase 4
3150
HMGN1
high-mobility group nucleosome binding domain 1
961
CD47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
79038
ZFYVE21
zinc finger, FYVE domain containing 21
7291
TWIST1
twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome)
(Drosophila)
9738
CP110
CP110 protein
10625
IVNS1ABP
influenza virus NS1A binding protein
9368
SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1
3613
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
8514
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
4957
ODF2
outer dense fiber of sperm tails 2
4673
NAP1L1
nucleosome assembly protein 1-like 1
26018
LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
3033
HADHSC
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain
139886
LOC139886
hypothetical protein LOC139886
10360
NPM3
nucleophosmin/nucleoplasmin, 3
200894
ARL2L1
ADP-ribosylation factor-like 2-like 1
8364
HIST1H4C
histone 1, H4c
378708
APITD1
apoptosis-inducing, TAF9-like domain 1
169270
ZNF596
zinc finger protein 596
6917
TCEA1
transcription elongation factor A (SII), 1
7091
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila )
3725
JUN
v-jun sarcoma virus 17 oncogene homolog (avian)
1736
DKC1
dyskeratosis congenita 1, dyskerin
8566
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
51176
LEF1
lymphoid enhancer-binding factor 1
87
ACTN1
actinin, alpha 1
10838
ZNF275
zinc finger protein 275
54517
FLJ20485
hypothetical protein FLJ20485
5150
PDE7A
phosphodiesterase 7A
384
ARG2
arginase, type II
27316
RBMX
RNA binding motif protein, X-linked
389206
CCDC4
coiled-coil domain containing 4
51312
SLC25A37
solute carrier family 25, member 37
9112
MTA1
metastasis associated 1
6711
SPTBN1
spectrin, beta, non-erythrocytic 1
10129
13CDNA73
hypothetical protein CG003
80014
BOMB
BH3-only member B protein
27131
SNX5
sorting nexin 5
23089
PEG10
paternally expressed 10
5270
SERPINE2
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator
inhibitor type 1), member 2
6764
ST5
suppression of tumorigenicity 5
7791
ZYX
zyxin
22995
Cep152
KIAA0912 protein
4137
MAPT
microtubule-associated protein tau
5411
PNN
pinin, desmosome associated protein
3087
HHEX
hematopoietically expressed homeobox
23171
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
56905
DKFZP434H132
DKFZP434H132 protein
3189
HNRPH3
heterogeneous nuclear ribonucleoprotein H3 (2H9)
9099
USP2
ubiquitin specific protease 2
10098
TSPAN5
tetraspanin 5
401505
C9orf105
chromosome 9 open reading frame 105
51444
RNF138
ring finger protein 138
11118
BTN3A2
butyrophilin, subfamily 3, member A2
8089
YEATS4
YEATS domain containing 4
84108
PCGF6
polycomb group ring finger 6
7514
XPO1
exportin 1 (CRM1 homolog, yeast)
9818
NUPL1
nucleoporin like 1
10923
PC4
activated RNA polymerase II transcription cofactor 4
6526
SLC5A3
solute carrier family 5 (inositol transporters), member 3
26010
DNAPTP6
DNA polymerase-transactivated protein 6
5307
PITX1
paired-like homeodomain transcription factor 1
2643
GCH1
GTP cyclohydrolase 1 (dopa-responsive dystonia)
1503
CTPS
CTP synthase
5777
PTPN6
protein tyrosine phosphatase, non-receptor type 6
23122
CLASP2
cytoplasmic linker associated protein 2
5588
PRKCQ
protein kinase C, theta
64770
CCDC14
coiled-coil domain containing 14
6426
SFRS1
splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)
81831
NETO2
neuropilin (NRP) and tolloid (TLL)-like 2
56888
KCMF1
potassium channel modulatory factor 1
9221
NOLC1
nucleolar and coiled-body phosphoprotein 1
79366
NSBP1
nucleosomal binding protein 1
51729
WBP11
WW domain binding protein 11
84444
DOTI L
DOT1-like, histone H3 methyltransferase ( S. cerevisiae )
80218
MAK3
Mak3 homolog ( S. cerevisiae )
84319
MGC4308
hypothetical protein MGC4308
112479
MGC16943
similar to RIKEN cDNA 4933424N09 gene
64396
GMCL1L
germ cell-less homolog 1 ( Drosophila )-like
5905
RANGAP1
Ran GTPase activating protein 1
2177
FANCD2
Fanconi anemia, complementation group D2
55632
KIAA1333
KIAA1333
3695
ITGB7
integrin, beta 7
9793
CKAP5
cytoskeleton associated protein 5
5318
PKP2
plakophilin 2
6652
SORD
sorbitol dehydrogenase
80709
AKNA
AT-hook transcription factor
55120
FANCL
Fanconi anemia, complementation group L
92667
C20orf72
chromosome 20 open reading frame 72
3654
IRAK1
interleukin-1 receptor-associated kinase 1
55975
KLHL7
kelch-like 7 ( Drosophila )
6397
SEC14L1
SEC14-like 1 ( S. cerevisiae )
29117
BRD7
bromodomain containing 7
6732
SRPK1
SFRS protein kinase 1
401081
FLJ22763
hypothetical gene supported by AK026416
8520
HAT1
histone acetyltransferase 1
3119
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
7283
TUBG1
tubulin, gamma 1
4809
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 ( S. cerevisiae )
2778
GNAS
GNAS complex locus
5359
PLSCR1
phospholipid scramblase 1
196294
FLJ25059
hypothetical protein FLJ25059
3181
HNRPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
1794
DOCK2
dedicator of cytokinesis 2
55148
C14orf130
chromosome 14 open reading frame 130
25924
MYRIP
myosin VIIA and Rab interacting protein
7533
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
polypeptide
64968
MRPS6
mitochondrial ribosomal protein S6
4830
NME1
non-metastatic cells 1, protein (NM23A) expressed in
165055
FLJ32745
hypothetical protein FLJ32745
151827
LRRC34
leucine rich repeat containing 34
93081
LOC93081
hypothetical protein BC015148
196527
TMEM16F
transmembrane protein 16F
1827
DSCR1
Down syndrome critical region gene 1
203562
TMEM31
transmembrane protein 31
11335
CBX3
chromobox homolog 3 (HP1 gamma homolog, Drosophila )
3662
IRF4
interferon regulatory factor 4
8624
DSCR2
Down syndrome critical region gene 2
4092
SMAD7
SMAD, mothers against DPP homolog 7 ( Drosophila )
6934
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
26112
DKFZP434C171
DKFZP434C171 protein
3329
HSPD1
heat shock 60kDa protein 1 (chaperonin)
5577
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
3202
HOXA5
homeo box AS
79442
LRRC2
leucine rich repeat containing 2
9631
NUP155
nucleoporin 155kDa
55366
LGR4
leucine-rich repeat-containing G protein-coupled receptor 4
23350
SR140
U2-associated SR140 protein
6434
SFRS10
splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila )
7975
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
3187
HNRPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
94239
H2AFV
H2A histone family, member V
54913
RPP25
ribonuclease P 25kDa subunit
9521
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
5471
PPAT
phosphoribosyl pyrophosphate amidotransferase
340252
ZNF680
zinc finger protein 680
1021
CDK6
cyclin-dependent kinase 6
10560
SLC19A2
solute carrier family 19 (thiamine transporter), member 2
4201
MEA1
male-enhanced antigen 1
440145
LOC440145
similar to RIKEN cDNA 2410129H14
3843
RANBP5
RAN binding protein 5
3298
HSF2
heat shock transcription factor 2
387914
TMEM46
transmembrane protein 46
27347
STK39
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
6256
RXRA
retinoid X receptor, alpha
6637
SNRPG
small nuclear ribonucleoprotein polypeptide G
22800
RRAS2
related RAS viral (r-ras) oncogene homolog 2
91694
FLJ23749
hypothetical protein FLJ23749
22823
MTF2
metal response element binding transcription factor 2
51184
MGC14560
protein x 0004
10856
RUVBL2
RuvB-like 2 ( E. coli )
7188
TRAF5
TNF receptor-associated factor 5
5272
SERPINB9
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9
11169
WDHD1
WD repeat and HMG-box DNA binding protein 1
5606
MAP2K3
mitogen-activated protein kinase kinase 3
4783
NFIL3
nuclear factor, interleukin 3 regulated
51691
LSM8
LSM8 homolog, U6 small nuclear RNA associated ( S. cerevisiae )
1528
CYB5
cytochrome b-5
79899
FLJ14213
hypothetical protein FLJ14213
7334
UBE2N
ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
2730
GCLM
glutamate-cysteine ligase, modifier subunit
23157
SEPT6
septin 6
56155
TEX14
testis expressed sequence 14
23658
LSM5
LSM5 homolog, U6 small nuclear RNA associated ( S. cerevisiae )
1400
CRMP1
collapsin response mediator protein 1
5684
PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
6713
SQLE
squalene epoxidase
84955
NUDCD1
NudC domain containing 1
64318
C10or1117
chromosome 10 open reading frame 117
10196
HRMT1L3
HMT1 hnRNP methyltransferase-like 3 ( S. cerevisiae )
29841
GRHL1
grainyhead-like 1 ( Drosophila )
10055
SAE1
SUMO-1 activating enzyme subunit 1
9214
FAIM3
Fas apoptotic inhibitory molecule 3
57406
ABHD6
abhydrolase domain containing 6
25914
RTTN
rotatin
23244
SCC-112
SCC-112 protein
3183
HNRPC
heterogeneous nuclear ribonucleoprotein C (C1/C2)
55117
SLC6A15
solute carrier family 6, member 15
6950
TCP1
t-complex 1
4660
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B
134429
STARD4
START domain containing 4, sterol regulated
157503
LOC157503
hypothetical protein LOC157503
253832
ZDHHC20
zinc finger, DHHC-type containing 20
375061
MGC15887
hypothetical gene supported by BC009447
84986
ARHGAP19
Rho GTPase activating protein 19
8407
TAGLN2
transgelin 2
285704
RGMB
RGM domain family, member B
5050
PAFAH1B3
platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa
4208
MEF2C
MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer
factor 2C)
55614
C20orf23
chromosome 20 open reading frame 23
388796
LOC388796
hypothetical LOC388796
85463
ZC3H12C
zinc finger CCCH-type containing 12C
51465
UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
9994
CASP8AP2
CASP8 associated protein 2
26135
PAI-RBP1
PAI-1 mRNA binding protein
5634
PRPS2
phosphoribosyl pyrophosphate synthetase 2
286319
TUSC1
tumor suppressor candidate 1
6470
SHMT1
serine hydroxymethyltransferase 1 (soluble)
9397
NMT2
N-myristoyltransferase 2
10762
NUP50
nucleoporin 50kDa
201161
PRR6
proline rich 6
5019
OXCT1
3-oxoacid CoA transferase 1
159
ADSS
adenylosuccinate synthase
23587
DERP6
S-phase 2 protein
10151
HNRPA3P1
heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
8564
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
1349
COX7B
cytochrome c oxidase subunit VIIb
283824
LOC283824
hypothetical protein LOC283824
1123
CHN1
chimerin (chimaerin) 1
57522
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
253782
LASS6
LAG1 longevity assurance homolog 6 ( S. cerevisiae )
57685
KIAA1573
KIAA1573 protein
79695
GALNT12
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl-
transferase 12 (GaINAc-T12)
90861
C16orf34
chromosome 16 open reading frame 34
26207
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
1164
CKS2
CDC28 protein kinase regulatory subunit 2
396
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
57530
CGN
cingulin
1633
DCK
deoxycytidine kinase
9208
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
6453
ITSN1
intersectin 1 (SH3 domain protein)
24147
FJX1
four jointed box 1 ( Drosophila )
9882
TBC1D4
TBC1 domain family, member 4
169200
DKFZp762C1112
hypothetical protein DKFZp762C1112
9331
B4GALT6
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
55183
RIF1
RAP1 interacting factor homolog (yeast)
221362
LOC221362
hypothetical protein LOC221362
8458
TTF2
transcription termination factor, RNA polymerase II
1047
CLGN
calmegin
56919
DHX33
DEAH (Asp-Glu-Ala-His) box polypeptide 33
93949
CXorf10
chromosome X open reading frame 10
5569
PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
6891
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
1960
EGR3
early growth response 3
11252
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
51762
RAB8B
RAB8B, member RAS oncogene family
81575
DKFZP434F0318
hypothetical protein DKFZp434F0318
56906
THAP10
THAP domain containing 10
55110
FLJ10292
mago-nashi homolog
5267
SERPINA4
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 4
1844
DUSP2
dual specificity phosphatase 2
9612
NCOR2
nuclear receptor co-repressor 2
3276
HRMT1L2
HMT1 hnRNP methyltransferase-like 2 ( S. cerevisiae )
257415
MGC40405
hypothetical protein MGC40405
79720
FLJ12750
hypothetical protein FLJ12750
160897
ITR
intimal thickness-related receptor
4522
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetra-
hydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
4668
NAGA
N-acetylgalactosaminidase, alpha-
84890
C10orf22
chromosome 10 open reading frame 22
5198
PFAS
phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
55544
RNPC1
RNA-binding region (RNP1, RRM) containing 1
2618
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide
synthetase, phosphoribosylaminoimidazole synthetase
9261
MAPKAPK2
mitogen-activated protein kinase-activated protein kinase 2
285761
DCBLD1
discoidin, CUB and LCCL domain containing 1
23225
NUP210
nucleoporin 210kDa
9792
SERTAD2
SERTA domain containing 2
56938
ARNTL2
aryl hydrocarbon receptor nuclear translocator-like 2
23254
KIAA1026
kazrin
4628
MYH10
myosin, heavy polypeptide 10, non-muscle
23176
SEPT8
septin 8
1432
MAPK14
mitogen-activated protein kinase 14
84549
RBM13
RNA binding motif protein 13
84133
ZNRF3
zinc and ring finger 3
6502
SKP2
S-phase kinase-associated protein 2 (p45)
59274
MESDC1
mesoderm development candidate 1
51496
HSPC129
hypothetical protein HSPC129
55151
TMEM38B
transmembrane protein 38B
57609
KIAA1463
KIAA1463 protein
1039
CDR2
cerebellar degeneration-related protein 2, 62kDa
143098
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
130589
GALM
galactose mutarotase (aldose 1-epimerase) lymphocyte cytosolic
3937
LCP2
protein 2 (SH2 domain containing leukocyte protein of 76kDa)
5420
PODXL
podocalyxin-like
6509
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
64397
ZFP106
zinc finger protein 106 homolog (mouse)
4860
NP
nucleoside phosphorylase
3535
IGL@
immunoglobulin lambda locus
1396
CRIP1
cysteine-rich protein 1 (intestinal)
1660
DHX9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
4291
MLF1
myeloid leukemia factor 1
26973
CHORDC1
cysteine and histidine-rich domain (CHORD)-containing, zinc binding protein 1
81037
CRR9
cisplatin resistance related protein CRR9p
10574
CCT7
chaperonin containing TCP1, subunit 7 (eta)
79892
C10orf119
chromosome 10 open reading frame 119
9972
NUP153
nucleoporin 153kDa
10459
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
483
ATP1B3
ATPase, Na+/K+ transporting, beta 3 polypeptide
7552
ZNF6
zinc finger protein 6 (CMPX1)
8165
AKAP1
A kinase (PRKA) anchor protein 1
29097
CNIH4
cornichon homolog 4 ( Drosophila )
11198
SUPT16H
suppressor of Ty 16 homolog ( S. cerevisiae )
2184
FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)
7037
TFRC
transferrin receptor (p90, CD71)
6461
SHB
Src homology 2 domain containing adaptor protein B
509
ATP5C1
ATP synthase, H+ transporting, mitochondrial F1complex, gamma polypeptide 1
5591
PRKDC
protein kinase, DNA-activated, catalytic polypeptide
10682
EBP
emopamil binding protein (sterol isomerase)
9188
DDX21
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
3837
KPNB1
karyopherin (importin) beta 1
3191
HNRPL
heterogeneous nuclear ribonucleoprotein L
10236
HNRPR
heterogeneous nuclear ribonucleoprotein R
6907
TBL1X
transducin (beta)-like 1X-linked
56172
ANKH
ankylosis, progressive homolog (mouse)
23367
LARP1
La ribonucleoprotein domain family, member 1
5778
PTPN7
protein tyrosine phosphatase, non-receptor type 7
100
ADA
adenosine deaminase
2821
GPI
glucose phosphate isomerase
9697
TRAM2
translocation associated membrane protein 2
54927
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
58478
MASA
E-1 enzyme
6322
SCML1
sex comb on midleg-like 1 ( Drosophila )
292
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator),
member 5
10857
PGRMC1
progesterone receptor membrane component 1
55342
STRBP
spermatid perinuclear RNA binding protein
7150
TOP1
topoisomerase (DNA) I
874
CBR3
carbonyl reductase 3
51096
WDR50
WD repeat domain 50
253558
LYCAT
lysocardiolipin acyltransferase
79053
ALG8
asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase)
84300
C6orf125
chromosome 6 open reading frame 125
8975
USP13
ubiquitin specific protease 13 (isopeptidase T-3)
220988
HNRPA3
heterogeneous nuclear ribonucleoprotein A3
5315
PKM2
pyruvate kinase, muscle
7411
VBP1
von Hippel-Lindau binding protein 1
1665
DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
10963
STIP1
stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)
253461
ZBTB38
zinc finger and BTB domain containing 38
29080
HSPC128
HSPC128 protein
84275
MGC4399
mitochondrial carrier protein
1622
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme
A binding protein)
4953
ODC1
ornithine decarboxylase 1
2029
ENSA
endosulfine alpha
6404
SELPLG
selectin P ligand
81034
MFTC
mitochondrial folate transporter/carrier
81542
TXNDC
thioredoxin domain containing
25816
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
51582
AZIN1
antizyme inhibitor 1
27436
EML4
echinoderm microtubule associated protein like 4
55720
FLJ10534
hypothetical protein FLJ10534
7295
TXN
thioredoxin
10539
TXNL2
thioredoxin-like 2
86
ACTL6A
actin-like 6A
6731
SRP72
signal recognition particle 72kDa
23314
SATB2
SATB family member 2
2273
FHL1
four and a half LIM domains 1
3422
IDI1
isopentenyl-diphosphate delta isomerase
10935
PRDX3
peroxiredoxin 3
2958
GTF2A2
general transcription factor IIA, 2, 12kDa
4144
MAT2A
methionine adenosyltransferase II, alpha
1964
EIF1AX
eukaryotic translation initiation factor 1A, X-linked
60
ACTB
actin, beta
11191
PTENP1
phosphatase and tensin homolog (mutated in multiple advanced cancers 1),
pseudogene 1
90843
TCEAL8
transcription elongation factor A (SII)-like 8
57181
SLC39A10
solute carrier family 39 (zinc transporter), member 10
11147
HHLA3
HERV-H LTR-associating 3
10553
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
3338
DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4
84888
SPPL2A
signal peptide peptidase-like 2A
1955
EGFL5
EGF-like-domain, multiple 5
329
BIRC2
baculoviral IAP repeat-containing 2
29927
SEC61A1
Sec61 alpha 1 subunit ( S. cerevisiae )
9559
VPS26
vacuolar protein sorting 26 (yeast)
23270
TSPYL4
TSPY-like 4
6309
SC5DL
sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like
10397
NDRG1
N-myc downstream regulated gene 1
27032
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
11112
HIBADH
3-hydroxyisobutyrate dehydrogenase
1476
CSTB
cystatin B (stefin B)
9620
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila )
56650
C3orf4
chromosome 3 open reading frame 4
29922
NME7
non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)
8887
TAXI BP1
Tax1 (human T-cell leukemia virus type I) binding protein 1
5445
PON2
paraoxonase 2
81889
FAHD1
fumarylacetoacetate hydrolase domain containing 1
694
BTG1
B-cell translocation gene 1, anti-proliferative
29058
C20orf30
chromosome 20 open reading frame 30
2752
GLUL
glutamate-ammonia ligase (glutamine synthase)
79717
FLJ11838
hypothetical protein FLJ11838
170622
COMMD6
COMM domain containing 6
5792
PTPRF
protein tyrosine phosphatase, receptor type, F
64393
WIG1
p53 target zinc finger protein
549
AUH
AU RNA binding protein/enoyl-Coenzyme A hydratase
51282
SCAND1
SCAN domain containing 1
79027
ZNF655
zinc finger protein 655
6451
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
1347
COX7A2
cytochrome c oxidase subunit Vlla polypeptide 2 (liver)
550643
L00550643
hypothetical protein L00550643
6926
TBX3
T-box 3 (ulnar mammary syndrome)
51614
SDBCAG84
serologically defined breast cancer antigen 84
9520
NPEPPS
aminopeptidase puromycin sensitive
51065
RPS27L
ribosomal protein S27-like
10116
FEM1B
fem-1 homolog b ( C. elegans )
10521
DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
81557
MAGED4
melanoma antigen family D, 4
10133
OPTN
optineurin
54504
CPVL
carboxypeptidase, vitellogenic-like
64062
C13orf10
chromosome 13 open reading frame 10
401115
LOC401115
hypothetical gene supported by BC038466; BC062790
6892
TAPBP
TAP binding protein (tapasin)
8087
FXR1
fragile X mental retardation, autosomal homolog 1
7905
C5orf18
chromosome 5 open reading frame 18
3916
LAMP1
lysosomal-associated membrane protein 1
22982
KIAA0934
KIAA0934
55615
PRR5
proline rich protein 5
5651
PRSS7
protease, serine, 7 (enterokinase)
10449
ACAA2
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme
A thiolase)
8934
RAB7L1
RAB7, member RAS oncogene family-like 1
10114
HIPK3
homeodomain interacting protein kinase 3
57560
WDR56
WD repeat domain 56
51205
ACP6
acid phosphatase 6, lysophosphatidic
6238
RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
151011
SEPT10
septin 10
22920
KIFAP3
kinesin-associated protein 3
3958
LGALS3
lectin, galactoside-binding, soluble, 3 (galectin 3)
84186
ZCCHC7
zinc finger, CCHC domain containing 7
9452
ITM2A
integral membrane protein 2A
10159
ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2
23641
LDOC1
leucine zipper, down-regulated in cancer 1
967
CD63
CD63 antigen (melanoma 1 antigen)
2517
FUCA1
fucosidase, alpha-L- 1, tissue
23219
FBXO28
F-box protein 28
79982
DNAJB14
DnaJ (Hsp40) homolog, subfamily B, member 14
7328
UBE2H
ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)
23355
KIAA0804
KIAA0804
257103
C21orf86
chromosome 21 open reading frame 86
6307
SC4MOL
sterol-C4-methyl oxidase-like
23376
KIAA0776
KIAA0776
57700
KIAA1600
KIAA1600
85461
TANG
TPR domain, ankyrin-repeat and coiled-coil-containing
4247
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
3383
ICAM1
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
493812
HCG11
HLA complex group 11
5921
RASA1
RAS p21 protein activator (GTPase activating protein) 1
23563
CHST5
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
51100
SH3GLB1
SH3-domain GRB2-like endophilin B1
339988
LOC339988
hypothetical protein LOC339988
79080
MGC2574
hypothetical protein MGC2574
55761
TTC17
tetratricopeptide repeat domain 17
144871
LOC144871
hypothetical protein LOC144871
4194
MDM4
Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)
51030
FAM18B
family with sequence similarity 18, member B
1650
DDOST
dolichyl-diphosphooligosaccharide-protein glycosyltransferase
147463
ANKRD29
ankyrin repeat domain 29
3757
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
116442
RAB39B
RAB39B, member RAS oncogene family
10972
TMP21
transmembrane trafficking protein
57798
GATAD1
GATA zinc finger domain containing 1
1314
COPA
coatomer protein complex, subunit alpha
2581
GALC
galactosylceramidase (Krabbe disease)
91452
ACBD5
acyl-Coenzyme A binding domain containing 5
8879
SGPL1
sphingosine-1-phosphate lyase 1
4897
NRCAM
neuronal cell adhesion molecule
23209
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
440270
LOC440270
golgin-67
5034
P4HB
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase),
beta polypeptide (protein disulfide isomerase-associated 1)
148646
FLJ32096
hypothetical protein FLJ32096
399917
LOC399917
similar to polymerase
7096
TLR1
toll-like receptor 1
80853
KIAA1718
KIAA1718 protein
378938
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
1266
CNN3
calponin 3, acidic
58486
LOC58486
transposon-derived Buster1 transposase-like protein gene
1040
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
9895
KIAA0329
KIAA0329
1509
CTSD
cathepsin D (lysosomal aspartyl protease)
26115
DKFZP564D166
putative ankyrin-repeat containing protein
57162
PELI1
pellino homolog 1 ( Drosophila )
57599
WDR48
WD repeat domain 48
285464
FLJ34443
hypothetical protein FLJ34443
55857
C20orf19
chromosome 20 open reading frame 19
339456
LOC339456
hypothetical protein LOC339456
51569
UFM1
ubiquitin-fold modifier 1
582
BBS1
Bardet-Biedl syndrome 1
4637
MYL6
myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
1186
CLCN7
chloride channel 7
3490
IGFBP7
insulin-like growth factor binding protein 7
5095
PCCA
propionyl Coenzyme A carboxylase, alpha polypeptide
10966
RAB40B
RAB40B, member RAS oncogene family
285362
SUMF1
sulfatase modifying factor 1
56122
PCDHB14
protocadherin beta 14
57534
MIB1
mindbomb homolog 1 ( Drosophila )
56951
C5orf15
chromosome 5 open reading frame 15
113177
C19orf36
chromosome 19 open reading frame 36
10379
ISGF3G
interferon-stimulated transcription factor 3, gamma 48kDa
64224
FLJ22313
hypothetical protein FLJ22313
65084
FLJ22104
hypothetical protein FLJ22104
10537
UBD
ubiquitin D
8548
BLZF1
basic leucine zipper nuclear factor 1 (JEM-1)
284214
LOC284214
hypothetical protein LOC284214
8334
HIST1H2AC
histone 1, H2ac
80210
FLJ12584
melanoma/melanocyte specific protein KU-MEL-1
1182
CLCN3
chloride channel 3
26751
SH3YL1
SH3 domain containing, Ysc84-like 1 ( S. cerevisiae )
114327
EFHC1
EF-hand domain (C-terminal) containing 1
7351
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
10724
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
9652
KIAA0372
KIAA0372
200958
MUC20
mucin 20
161527
LOC161527
hypothetical protein LOC161527
10314
LANCL1
LanC lantibiotic synthetase component C-like 1 (bacterial)
2923
PDIA3
protein disulfide isomerase family A, member 3
84247
LDOC1L
leucine zipper, down-regulated in cancer 1-like
3006
HIST1H1C
histone 1, H1c
9562
MINPP1
multiple inositol polyphosphate histidine phosphatase, 1
115024
MGC20781
hypothetical protein MGC20781
65982
FLJ12895
hypothetical protein FLJ12895
5268
SERPINB5
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
94240
EPSTI1
epithelial stromal interaction 1 (breast)
2621
GAS6
growth arrest-specific 6
401024
FLJ44048
FLJ44048 protein
57142
RTN4
reticulon 4
50854
C6orf48
chromosome 6 open reading frame 48
317649
EIF4E3
eukaryotic translation initiation factor 4E member 3
4179
MCP
membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
54884
RetSat
all-trans-13,14-dihydroretinol saturase
10154
PLXNC1
plexin C1
2630
GBAP
glucosidase, beta; acid, pseudogene
7077
TIMP2
tissue inhibitor of metalloproteinase 2
23741
CRI1
CREBBP/EP300 inhibitor 1
949
SCARB1
scavenger receptor class B, member 1
1519
CTSO
cathepsin O
51136
LOC51136
PTD016 protein
3428
IFI16
interferon, gamma-inducible protein 16
9516
LITAF
lipopolysaccharide-induced TNF factor
3123
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
1389
CREBL2
cAMP responsive element binding protein-like 2
5027
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
6782
STCH
stress 70 protein chaperone, microsome-associated, 60kDa
5645
PRSS2
protease, serine, 2 (trypsin 2)
84282
RNF135
ring finger protein 135
9852
EPM2AIP1
EPM2A (laforin) interacting protein 1
84333
PCGF5
polycomb group ring finger 5
23475
QPRT
quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase
(carboxylating))
11142
PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
54832
VPS13C
vacuolar protein sorting 13C (yeast)
1486
CTBS
chitobiase, di-N-acetyl-
4601
MXI1
MAX interactor 1
1365
CLDN3
claudin 3
81622
UNC93B1
unc-93 homolog B1 ( C. elegans )
54664
FLJ11273
hypothetical protein FLJ11273
9993
DGCR2
DiGeorge syndrome critical region gene 2
57179
KIAA1191
KIAA1191 protein
55958
KLHL9
kelch-like 9 ( Drosophila )
81671
TMEM49
transmembrane protein 49
9666
DZIP3
zinc finger DAZ interacting protein 3
10509
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and
short cytoplasmic domain, (semaphorin) 4B
3782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily
N, member 3
4644
MYO5A
myosin VA (heavy polypeptide 12, myoxin)
55179
FAIM
Fas apoptotic inhibitory molecule
9687
GREB1
GREB1 protein
25861
DFNB31
deafness, autosomal recessive 31
9197
SLC33A1
solute carrier family 33 (acetyl-CoA transporter), member 1
10549
PRDX4
peroxiredoxin 4
27090
ST6GALNAC4
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide
alpha-2,6-sialyltransferase 4
3988
LIPA
lipase A, lysosomal acid, cholesterol esterase (Wolman disease)
10577
NPC2
Niemann-Pick disease, type C2
441951
HSUP1
similar to RPE-spondin
26275
HIBCH
3-hydroxyisobutyryl-Coenzyme A hydrolase
401397
LOC401397
hypothetical LOC401397
81555
YIPF5
Yip1 domain family, member 5
19
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
2896
GRN
granulin
1312
COMT
catechol-O-methyltransferase
127018
LYPLAL1
lysophospholipase-like 1
5911
RAP2A
RAP2A, member of RAS oncogene family
3017
HIST1H2BD
histone 1, H2bd
9139
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
50848
F11R
F11 receptor
3728
JUP
junction plakoglobin
8615
VDP
vesicle docking protein p115
79090
MGC2650
hypothetical protein MGC2650
51303
FKBP11
FK506 binding protein 11, 19kDa
64747
MFSD1
major facilitator superfamily domain containing 1
23471
TRAM1
translocation associated membrane protein 1
1832
DSP
desmoplakin
125144
MGC40157
hypothetical protein MGC40157
10150
MBNL2
muscleblind-like 2 ( Drosophila )
3082
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
7750
ZNF198
zinc finger protein 198
2908
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
25758
G2
G2 protein
10653
SPINT2
serine protease inhibitor, Kunitz type, 2
116151
C20orf108
chromosome 20 open reading frame 108
8933
CXX1
CAAX box 1
475
ATOX1
ATX1 antioxidant protein 1 homolog (yeast)
23406
COTL1
coactosin-like 1 ( Dictyostelium )
57561
ARRDC3
arrestin domain containing 3
55205
ZNF532
zinc finger protein 532
25796
PGLS
6-phosphogluconolactonase
283846
DKFZp547E087
P1-3-kinase-related kinase SMG-1-like
57185
DJ462023.2
hypothetical protein dJ462O23.2
54431
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
5800
PTPRO
protein tyrosine phosphatase, receptor type, O
1465
CSRP1
cysteine and glycine-rich protein 1
950
SCARB2
scavenger receptor class B, member 2
51019
CGI-116
CGI-116 protein
5476
PPGB
protective protein for beta-galactosidase (galactosialidosis)
54145
H2BFS
H2B histone family, member S
65981
C1QDC1
C1q domain containing 1
81502
HM13
histocompatibility (minor) 13
3572
IL6ST
interleukin 6 signal transducer (gp130, oncostatin M receptor)
1299
COL9A3
collagen, type IX, alpha 3
1386
ATF2
activating transcription factor 2
4134
MAP4
microtubule-associated protein 4
3981
LIG4
ligase IV, DNA, ATP-dependent
57714
KIAA1618
KIAA1618
80315
CPEB4
cytoplasmic polyadenylation element binding protein 4
107
ADCY1
adenylate cyclase 1 (brain)
8804
CREG1
cellular repressor of E1A-stimulated genes 1
84181
CHD6
chromodomain helicase DNA binding protein 6
22871
NLGN1
neuroligin 1
659
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
79158
MGC4170
MGC4170 protein
112399
EGLN3
egl nine homolog 3 ( C. elegans )
10550
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
55573
H41
hypothetical protein H41
51706
NQO3A2
NAD(P)H:quinone oxidoreductase type 3, polypeptide A2
79738
FLJ23560
hypothetical protein FLJ23560
6672
SP100
nuclear antigen Sp100
145173
B3GTL
beta 3-glycosyltransferase-like
3275
HRMT1L1
HMT1 hnRNP methyltransferase-like 1 ( S. cerevisiae )
54059
C21orf57
chromosome 21 open reading frame 57
571
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
6990
TCTE1L
t-complex-associated-testis-expressed 1-like
9341
VAMP3
vesicle-associated membrane protein 3 (cellubrevin)
2180
ACSL1
acyl-CoA synthetase long-chain family member 1
2799
GNS
glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID)
9236
CCPG1
cell cycle progression 1
51111
SUV420H1
suppressor of variegation 4-20 homolog 1 ( Drosophila )
598
BCL2L1
BCL2-like 1
57674
C17orf27
chromosome 17 open reading frame 27
1488
CTBP2
C-terminal binding protein 2
80267
C1orf22
chromosome 1 open reading frame 22
90701
SEC11L3
SEC11-like 3 ( S. cerevisiae )
84218
TBC1D3
TBC1 domain family, member 3
7844
RNF103
ring finger protein 103
8440
NCK2
NCK adaptor protein 2
25934
NIPSNAP3A
nipsnap homolog 3A ( C. elegans )
3897
L1CAM
L1 cell adhesion molecule
114915
TIGA1
TIGA1
754
PTTG1IP
pituitary tumor-transforming 1 interacting protein
10525
HYOU1
hypoxia up-regulated 1
966
CD59
CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16,
EJ30, EL32 and G344)
25976
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
3714
JAG2
jagged 2
8780
RIOK3
RIO kinase 3 (yeast)
55827
IQWD1
IQ motif and WD repeats 1
55830
GLT8D1
glycosyltransferase 8 domain containing 1
4779
NFE2L1
nuclear factor (erythroid-derived 2)-like 1
7286
TUFT1
tuftelin 1
1028
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
60492
MDS025
hypothetical protein MDS025
27319
BHLHB5
basic helix-loop-helix domain containing, class B, 5
1958
EGR1
early growth response 1
89796
NAV1
neuron navigator 1
9240
PNMA1
paraneoplastic antigen MA1
6773
STAT2
signal transducer and activator of transcription 2, 113kDa
7494
XBP1
X-box binding protein 1
11057
ABHD2
abhydrolase domain containing 2
9451
EIF2AK3
eukaryotic translation initiation factor 2-alpha kinase 3
8878
SQSTM1
sequestosome 1
302
ANXA2
annexin A2
2590
GALNT2
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-
acetylgalactosaminyltransferase 2 (GaINAc-T2)
1200
TPP1
tripeptidyl peptidase I
5973
RENBP
renin binding protein
7259
TSPYL1
TSPY-like 1
112770
C1orf85
chromosome 1 open reading frame 85
93953
ACRC
acidic repeat containing
90634
CG018
hypothetical gene CG018
1030
CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
158158
RASEF
RAS and EF hand domain containing
2824
GPM6B
glycoprotein M6B
9706
ULK2
unc-51-like kinase 2 ( C. elegans )
92370
ACPL2
acid phosphatase-like 2
1203
CLN5
ceroid-lipofuscinosis, neuronal 5
8337
HIST2H2AA
histone 2, H2aa
3998
LMAN1
lectin, mannose-binding, 1
56675
NRIP3
nuclear receptor interacting protein 3
4864
NPC1
Niemann-Pick disease, type Cl
3358
HTR2C
5-hydroxytryptamine (serotonin) receptor 2C
304
ANXA2P2
annexin A2 pseudogene 2
81790
RNF170
ring finger protein 170
2537
G1P3
interferon, alpha-inducible protein (clone IFI-6-16)
55251
C20orf36
chromosome 20 open reading frame 36
27344
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
10057
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
81031
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
467
ATF3
activating transcription factor 3
94103
ORMDL3
ORM1-like 3 ( S. cerevisiae )
375593
TRIM50B
tripartite motif-containing 50B
23015
GM88
88-kDa golgi protein
55818
JMJD1A
jumonji domain containing 1A
5274
SERPINI1
serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1
23336
DMN
desmuslin
255631
COL24A1
collagen, type XXIV, alpha 1
3995
FADS3
fatty acid desaturase 3
5797
PTPRM
protein tyrosine phosphatase, receptor type, M
55876
GSDML
gasdermin-like
999
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
84897
TBRG1
transforming growth factor beta regulator 1
51363
GALNAC4S-6ST
B cell RAG associated protein
9961
MVP
major vault protein
2982
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
706
BZRP
benzodiazapine receptor (peripheral)
144203
OVOS2
ovostatin 2
8516
ITGA8
integrin, alpha 8
2037
EPB41L2
erythrocyte membrane protein band 4.1-like 2
1524
CX3CR1
chemokine (C-X3-C motif) receptor 1
222166
Ells1
hypothetical protein Ells1
339803
LOC339803
hypothetical protein LOC339803
5360
PLTP
phospholipid transfer protein
1612
DAPK1
death-associated protein kinase 1
90161
HS6ST2
heparan sulfate 6-O-sulfotransferase 2
115701
ALPK2
alpha-kinase 2
50640
IPLA2(GAMMA)
intracellular membrane-associated calcium-independent phospholipase A2 gamma
8473
OGT
O-linked N-acetylglucosamine (GIcNAc) transferase (UDP-N-acetylglucosamine:
polypeptide-N-acetylglucosaminyl transferase)
252839
TMEM9
transmembrane protein 9
150759
LOC150759
hypothetical protein LOC150759
401152
LOC401152
HCV F-transactivated protein 1
64065
PERP
PERP, TP53 apoptosis effector
114793
FMNL2
formin-like 2
477
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide
59338
PLEKHAl
pleckstrin homology domain containing, family A (phosphoinositide binding
specific) member 1
3727
JUND
jun D proto-oncogene
85236
HIST1H2BK
histone 1, H2bk
6513
SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
155038
GIMAP8
GTPase, IMAP family member 8
3055
HCK
hemopoietic cell kinase
6542
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
8996
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
9728
KIAA0256
KIAA0256 gene product
51237
PACAP
proapoptotic caspase adaptor protein
8987
GENX-3414
genethonin 1
132720
FLJ39370
hypothetical protein FLJ39370
1601
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein ( Drosophila )
54741
LEPROT
leptin receptor overlapping transcript
81631
MAP1LC3B
microtubule-associated protein 1 light chain 3 beta
9473
C1orf38
chromosome 1 open reading frame 38
94241
TP53INP1
tumor protein p53 inducible nuclear protein 1
5816
PVALB
parvalbumin
115294
LOC115294
similar to hypothetical protein FLJ10883
23461
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
10370
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
9604
RNF14
ring finger protein 14
387263
C6orf120
chromosome 6 open reading frame 120
9120
SLC16A6
solute carrier family 16 (monocarboxylic acid transporters), member 6
3915
LAMC1
laminin, gamma 1 (formerly LAMB2)
23092
ARHGAP26
Rho GTPase activating protein 26
64778
FNDC3B
fibronectin type III domain containing 3B
10140
TOB1
transducer of ERBB2, 1
23208
SYT11
synaptotag min XI
57730
KIAA1641
KIAA1641
120196
MGC34830
hypothetical protein MGC34830
7832
BTG2
BTG family, member 2
23259
DDHD2
DDHD domain containing 2
84981
MGC14376
hypothetical protein MGC14376
6448
SGSH
N-sulfoglucosamine sulfohydrolase (sulfamidase)
9910
RABGAP1L
RAB GTPase activating protein 1-like
1611
DAP
death-associated protein
126823
KARCA1
kelch/ankyrin repeat containing cyclin Al interacting protein
388403
YPEL2
yippee-like 2 ( Drosophila )
6720
SREBF1
sterol regulatory element binding transcription factor 1
58476
TP53INP2
tumor protein p53 inducible nuclear protein 2
8605
PLA2G4C
phospholipase A2, group IVC (cytosolic, calcium-independent)
3983
ABLIM1
actin binding LIM protein 1
4189
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
1604
DAF
decay accelerating factor for complement (CD55, Cromer blood group system)
29994
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
10156
RASA4
RAS p21 protein activator 4
9123
SLC16A3
solute carrier family 16 (monocarboxylic acid transporters), member 3
7846
TUBA3
tubulin, alpha 3
3956
LGALS1
lectin, galactoside-binding, soluble, 1 (galectin 1)
1647
GADD45A
growth arrest and DNA-damage-inducible, alpha
6609
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase)
56904
SH3GLB2
SH3-domain GRB2-like endophilin B2
440081
DDX12
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 (CHL1-like helicase
homolog, S. cerevisiae )
5163
PDK1
pyruvate dehydrogenase kinase, isoenzyme 1
25840
DKFZP586A0522
DKFZP586A0522 protein
51566
ARMCX3
armadillo repeat containing, X-linked 3
9388
LIPG
lipase, endothelial
27250
PDCD4
programmed cell death 4 (neoplastic transformation inhibitor)
6302
SAS
sarcoma amplified sequence
83937
RASSF4
Ras association (RaIGDS/AF-6) domain family 4
388677
NOTCH2NL
Notch homolog 2 ( Drosophila ) N-terminal like
23646
PLD3
phospholipase D family, member 3
23643
LY96
lymphocyte antigen 96
9855
FARP2
FERM, RhoGEF and pleckstrin domain protein 2
65018
PINK1
PTEN induced putative kinase 1
57035
C1orf63
chromosome 1 open reading frame 63
85352
KIAA1644
KIAA1644 protein
283131
TncRNA
trophoblast-derived noncoding RNA
143888
KDELC2
KDEL (Lys-Asp-Glu-Leu) containing 2
56204
FLJ10980
hypothetical protein FLJ10980
23446
CDW92
CDW92 antigen
23766
GABARAPL3
GABA(A) receptors associated protein like 3
1508
CTSB
cathepsin B
4094
MAF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
22932
POMZP3
POM (POM121 homolog, rat) and ZP3 fusion
56243
KIAA1217
KIAA1217
1663
DDX11
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase
homolog, S. cerevisiae )
1414
CRYBB1
crystallin, beta B1
154091
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
4121
MAN1A1
mannosidase, alpha, class 1A, member 1
11178
LZTS1
leucine zipper, putative tumor suppressor 1
10628
TXNIP
thioredoxin interacting protein
83719
YPEL3
yippee-like 3 ( Drosophila )
9863
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
5660
PSAP
prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)
145788
FLJ27352
hypothetical LOC145788
84513
HTPAP
HTPAP protein
57612
KIAA1466
KIAA1466 gene
57515
TDE2
tumor differentially expressed 2
29005
PRO1073
PRO1073 protein
51646
YPEL5
yippee-like 5 ( Drosophila )
5269
SERPINB6
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6
30061
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
81030
ZBP1
Z-DNA binding protein 1
347733
RP11-506K6.1
tubulin, beta polypeptide paralog
390
RND3
Rho family GTPase 3
10765
JARID1B
Jumonji, AT rich interactive domain 1B (RBP2-like)
9783
RIMS3
regulating synaptic membrane exocytosis 3
27122
DKK3
dickkopf homolog 3 (Xenopus laevis)
151556
GPR155
G protein-coupled receptor 155
8365
HIST1H4H
histone 1, H4h
6480
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
6591
SNAI2
snail homolog 2 ( Drosophila )
54800
DRE1
DRE1 protein
3669
ISG20
interferon stimulated exonuclease gene 20kDa
23710
GABARAPL1
GABA(A) receptor-associated protein like 1
400172
LOC400172
similar to KIAA1641 protein; melanoma-associated antigen; CLL-associated
antigen KW-1
153222
LOC153222
adult retina protein
54981
C9orf95
chromosome 9 open reading frame 95
5641
LGMN
legumain
257019
FRMD3
FERM domain containing 3
8357
HIST1H3H
histone 1, H3h
55281
FLJ11000
hypothetical protein FLJ11000
4050
LTB
lymphotoxin beta (TNF superfamily, member 3)
203
AK1
adenylate kinase 1
5920
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
284801
LOC284801
hypothetical protein LOC284801
150271
LOC150271
hypothetical protein LOC150271.
33. A method of identifying a patient for treatment of a cell proliferative disorder with an inhibitor of FGFR3, the method comprising:
testing a sample obtained from the patient after administration of the inhibitor to measure gene expression of at least one biomarker selected from the group consisting of CCL3, DUSP6, ANXA9, CR2, AL531683, ZNF589, AW274468, FRMD3, LTB, and WDR42A, wherein at least one selected biomarker is CCL3,
wherein detection of an alteration in level of expression compared to a baseline gene expression measurement of the at least one biomarker is indicative of the candidacy of the patient for treatment,
wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.
34. A method of monitoring response of a patient to treatment by an inhibitor of FGFR3 for a cell proliferative disorder, the method comprising:
testing a sample obtained from the patient after administration of the inhibitor of FGFR3 to measure gene expression of at least one biomarker selected from the group consisting of CCL3, DUSP6, ANXA9, CR2, AL531683, ZNF589, AW274468, FRMD3, LTB, and WDR42A, wherein at least one selected biomarker is CCL3,
wherein detection of an alteration in level of expression of the at least one biomarker compared to a baseline gene expression measurement is indicative of a response of the patient to the treatment, and
wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.