Humanized antibodies against human interferon-alpha
The present invention provides humanized anti-human IFN-α monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.
1. An isolated IgG4 isotype antibody that binds human interferon-α and comprises a VH domain comprising SEQ ID NO:3 and a VL domain comprising SEQ ID NO:6.
2. An isolated antibody comprising at least one light chain that comprises the CDRs:
VLI having the amino acid sequence of SEQ ID NO: 18;
VL2 haying the amino acid sequence of SEQ ID NO: 179; and
VL3, having the amino acid sequence of SEQ ID NO:20, and
at least one heavy chain that comprises the CDRs:
VHI having the amino acid sequence of SEQ ID NO: 15;
VH2 having the amino acid sequence of SEQ ID NO:21; and
VH3 having the amino acid sequence of SEQ ID NO:I 7.