Anthranilic acid amides and derivatives thereof as cosmetic and pharmaceutical agents
The use of specific compounds of the Formula 1 (and also corresponding mixtures) in particular as cosmetic agents for the inhibition of the substance P-induced release of histamine from mast cells is described.
1. Compound of the Formula 1,
where:
m=0, 1, 2 or 3,
p=0 or 1,
n=1,
with the proviso that the sum of p +m >0,
where R 1 and R 2 denote H;
where, when m=1, 2 or 3, each X, independently of the others, denotes OH, Oalkyl or Oacyl,
where, when p=1, Y denotes OH or Oalkyl,
with the proviso that X has been selected at least once from the group that consists of OH and Oacyl or Y is OH;
R 3 =H or alkyl.
2. Compound of the Formula 1a,
where:
m=2,
where, each X is independently Oalkyl or Oacyl,
with the proviso that X has been selected once from Oacyl and once from Oalkyl;
R 3 =alkyl.
3. A compound according to claim 1 , selected from the group consisting of:
4. Compound of the Formula 1,
where:
m=0, 1 or 2,
p=2,
n=1
with the proviso that the sum of p+m >0,
where R 1 and R 2 , in each case in pairs, in each case denote H or together denote a further chemical bond;
where, when m=1 or 2, each X, independently of the others, denotes OH or Oacyl,
where, when p=2, each Y, independently of the others, denotes OH or Oacyl, with the proviso that X or Y has been selected at least once from the group that consists of OH and Oacyl;
R 3 =H or alkyl.