IP Library › Granted Patent US 8,211,457
Granted Patent B2
US 8,211,457 · App. 12/723,548 · Granted Jul 3, 2012

Isocyanate coatings for implantable devices and a method of forming the same

Assignee: Advanced Cardiovascular Systems, Inc.
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Quick Facts
Patent No.
US 8,211,457
App. No.
12/723,548
Granted
Jul 3, 2012
Kind
B2
Abstract

Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.

Claims (16)

1. An implantable device comprising a coating, the coating comprising:

a) a reservoir region comprising a polymer and a drug blended with or dispersed in the polymer; and

b) a primer region free from any drugs located between the reservoir region and the surface of the implantable device, the primer region comprising a material comprising a polyisocyanate selected from the group consisting of triisocyanurate, polymethylene polyphenyl isocyanate, polyester polyurethanes, and combinations thereof.

2. The implantable device of claim 1 , wherein the implantable device is a stent.

3. The implantable device of claim 1 , wherein the surface of the implantable device includes a chromium oxide layer.

4. The implantable device of claim 1 , wherein the surface of the implantable device is metallic.

5. The implantable device of claim 1 , wherein the reservoir region comprises a combination of polymers.

6. A stent comprising a coating, wherein the coating comprises:

a) a reservoir region comprising a drug; and

b) a primer region free from any drugs located between the reservoir region and the surface of the stent, the primer region comprising a material comprising a polyisocyanate selected from the group consisting of triisocyanurate, polymethylene polyphenyl isocyanate, polyester polyurethanes, and combinations thereof.

7. The implantable device of claim 1 , wherein the polyisocyanate comprises triisocyanurate.

8. The implantable device of claim 1 , wherein the polyisocyanate comprises polymethylene polyphenyl isocyanate.

9. The implantable device of claim 1 , wherein the polyisocyanate comprises polyester polyurethane.

10. The implantable device of claim 6 , wherein the polyisocyanate comprises triisocyanurate.

11. The implantable device of claim 6 , wherein the polyisocyanate comprises polymethylene polyphenyl isocyanate.

12. The implantable device of claim 6 , wherein the polyisocyanate comprises polyester polyurethane.

Continuity (3)
Division 10751289 · Jan 2, 2004
Continuation 09750595 · Dec 28, 2000
Related Publication 20110070283A1 · Mar 24, 2011