Pharmaceutical preparation for oral administration with controlled active ingredient release in the small intestine and method for its production

1. A pharmaceutical preparation for oral administration with controlled release of active ingredient in the small bowel comprising:

a) active ingredient carriers comprising (1R,3r,5S)-3-[(hydroxydiphenylacetyl)oxy]spiro[8-azoniabicyclo[3.2.1]octane-8,1′-pyrrolidinium]chloride as the active agent, and optionally a binder, buffer substances, a plasticizer and/or an antitack agent;

b) an inner layer coated on the active ingredient carriers to control the release of active ingredient comprising:

i) a first diffusion layer comprising polyvinyl acetate as the matrix material and polyvinyl alcohol-polyethylene glycol copolymers as the pore former, and optionally a plasticizer and/or an antitack agent; and

ii) a second diffusion layer comprising polyvinyl acetate as the matrix material and polyvinyl alcohol-polyethylene glycol copolymers as the pore former present in an amount less than the amount of pore former used in the first diffusion layer, and optionally a plasticizer and/or an antitack agent; and

c) optionally, a gastro-resistant coating layer disposed thereon,

wherein the permeability for the diffusing active ingredient decreases from the inside to the outside; and

wherein <75% of the active agent of the pharmaceutical preparation is released in 60 minutes releasing the active agent at a constant rate.