Lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases
The present invention relates to methods of treating a hyperproliferative disease by administering a composition of lactoferrin alone or in combination with standard anti-cancer therapies.
1. A method of treating non small cell lung and renal cancer in a mammalian subject in need thereof comprising administering chemotherapy, biotherapy, immunotherapy, surgery, radiotherapy, or a combination thereof to the subject in combination with orally administering to the subject a therapeutically effective amount of full-length mature human lactoferrin composition.
2. The method of claim 1 , wherein the lactoferrin composition is administered in combination with chemotherapy, radiotherapy, or both.
3. The method of claim 1 , wherein the chemotherapy comprises paclitaxel, docetaxel, doxorubicin, daunorubicin, adriamycin, mitomycin, actinomycin D, bleomycin, plicomycin, vincristine, vinblastine, cisplatin, etoposide, Tumor Necrosis Factor, carmustine, melphalan, cyclophosphamide, chlorambucil, busulfan, docetaxel, lomustine, carboplatin, procarbazine, mechlorethamine, irinotecan, topotecan, ifosfamide, nitrosurea, tamoxifen, raloxifene, toremifene, idoxifene, droloxifene, TAT-59, zindoxifene, trioxifene, ICI 182,780, EM-800, gemcitabinen, navelbine, transplatinum, 5-Fluorouracil, methotrexate, temazolomide, mylotarg, dolastatin-10, or bryostatin.
4. The method of claim 1 , wherein the chemotherapy comprises a platinum-based chemotherapy.
5. The method of claim 4 , wherein the platinum-based chemotherapy comprises cisplatin or carboplatin.
6. The method of claim 1 , wherein the chemotherapy comprises a taxane-based chemotherapy.
7. The method of claim 6 , wherein the taxane-based chemotherapy comprises docetaxel.
8. The method of claim 1 , wherein the chemotherapy comprises paclitaxel.
9. The method of claim 1 , wherein the lactoferrin composition is administered in combination with radiotherapy.
10. The method of claim 1 , wherein the lactoferrin composition is administered in combination with biotherapy.
11. The method of claim 1 , wherein the lactoferrin composition is administered in combination with immunotherapy.
12. The method of claim 1 , wherein the lactoferrin composition is administered in combination with surgery.