Alkylglycoside compositions for drug administration
The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject. The compositions include at least one alkyl glycoside and at least one therapeutic agent, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms.
1. A pharmaceutical composition comprising:
a) a triptan analog selected from sumatriptan, naratriptan, zolmitriptan, eletriptan, almotriptan, frovatriptan; and
b) an absorption increasing amount of an alkylglycoside, wherein the alkylglycoside comprises a maltose linked by glycosidic linkage to an alkyl chain comprising between 12 to 16 carbons, and wherein the concentration of alkylglycoside is between 0.05% and 20% by weight.
2. The pharmaceutical composition of claim 1 , wherein the triptan analog is sumatriptan.
3. The pharmaceutical composition of claim 1 , wherein the alkylglycoside is selected from the group consisting of dodecyl maltoside, tridecyl maltoside, and tetradecyl maltoside.
4. The pharmaceutical composition of claim 3 , wherein the alkylglycoside consists of tetradecyl-β-D-maltoside.
5. The pharmaceutical composition of claim 3 , wherein the alkylglycoside consists of dodecyl-β-D-maltoside.
6. The pharmaceutical composition of claim 3 , wherein the alkylglycoside consists of tridecyl-β-D-maltoside.
7. The pharmaceutical composition of claim 1 , wherein the triptan analog is sumatriptan.
8. The pharmaceutical composition of claim 1 , wherein the triptan analog is naratriptan.
9. The pharmaceutical composition of claim 1 , wherein the triptan analog is zolmitriptan.
10. The pharmaceutical composition of claim 1 , wherein the triptan analog is eletriptan.
11. The pharmaceutical composition of claim 1 , wherein the triptan analog is almotriptan.
12. The pharmaceutical composition of claim 1 , wherein the triptan analog is frovatriptan.
13. The pharmaceutical composition of claim 1 , wherein the alkylglycoside is dodecyl maltoside, and wherein the triptan analog is sumatriptan.
14. The pharmaceutical composition of claim 1 , further comprising ethylenediaminetetraacetic acid (EDTA).
15. The pharmaceutical composition of claim 1 , wherein the alkylglycoside is a β-anomer.