IP Library Granted Patent US 8,278,312
Granted Patent B2
US 8,278,312 · App. 12/682,316 · Granted Oct 2, 2012

Imidazo 1,2-

Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
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Quick Facts
Patent No.
US 8,278,312
App. No.
12/682,316
Granted
Oct 2, 2012
Kind
B2
Abstract

Novel compounds of the formula (I), in which W, T, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and X 7 have the meanings indicated in Patent Claim 1 , are suitable as antidiabetics.

Claims (97)

1. A compound selected from the following compounds A1 to A27:

No.

Structure and/or name

“A1”

2-{2-[3-(2,6-Dimethylphenylamino)imidazo[1,2-a]pyrimidin-

2-yl]phenoxy}acetamide

“A2”

2-{2-[3-(2,6-Dimethylphenylamino)-5,7-dimethylimidazo-

[1,2-a]pyrimidin-2-yl]phenoxy}acetamide

“A3”

(2,6-Dichlorophenyl)-{2-[2,4-dimethoxy-6-(5-methylamino-

1,3,4-oxadiazol-2-yl)phenyl]imidazo[1,2-a]pyrimidin-3-yl}-

amine

“A4”

(2,6-Dichloro-4-fluorophenyl)-{2-[2,4-dimethoxy-6-(5-

methylamino-1,3,4-oxadiazol-2-yl)phenyl]imidazo[1,2-a]-

pyrimidin-3-yl}amine

“A5”

(2,6-Dichlorophenyl)-{2-[2-(5-ethylamino-1,3,4-oxadiazol-2-

yl)-4,6-dimethoxyphenyl]imidazo[1,2-a]pyrimidin-3-yl}amine

“A6”

5-{2-[3-(2,6-Dichlorophenylamino)imidazo[1,2-a]pyrimidin-

2-yl]-3,5-dimethoxyphenyl}-3H-1,3,4-oxadiazol-2-one

“A7”

2-{2-[3-(2,6-Dichlorophenylamino)imidazo[1,2-a]pyrimidin-

2-yl]-3-ethylphenoxy}acetamide

“A8”

2-{2-[3-(2,6-Dimethylphenylamino)imidazo[1,2-a]pyrimidin-

2-yl]-3-ethylphenoxy}acetamide

“A9”

2-{2-[3-(2,6-Dimethylphenylamino)imidazo[1,2-a]pyrimidin-

2-yl]-3-ethyl-5-methoxyphenoxy}acetamide

“A10”

2-{2-[3-(2,6-Dimethylphenylamino)imidazo[1,2-a]pyrimidin-

2-yl]-5-methoxy-3-methylphenoxy}acetamide

“A11”

{2-[2,4-Dimethoxy-6-(5-methylamino-1,3,4-oxadiazol-2-yl)-

phenyl]imidazo[1,2-a]pyrimidin-3-yl}-(2,6-dimethylphenyl)-

amine

“A12”

2-{2-[3-(2,6-Dichlorophenylamino)imidazo[1,2-a]pyrimidin-

2-yl]-3-ethyl-5-methoxyphenoxy}acetamide

“A13”

(2,6-Dichloro-4-fluorophenyl)-{2-[2-(5-methylamino-1,3,4-

oxadiazol-2-yl)phenyl]imidazo[1,2-a]pyrimidin-3-yl}amine

“A14”

(2,6-Dichlorophenyl)-{2-[2-(5-methylamino-1,3,4-oxadiazol-

2-yl)phenyl]imidazo[1,2-a]pyrimidin-3-yl}amine

“A15”

(2,6-Dichlorophenyl)-{2-[2-(5-ethylamino-1,3,4-oxadiazol-2-

yl)phenyl]imidazo[1,2-a]pyrimidin-3-yl}amine

“A16”

{2-[2,4-Dichloro-6-(5-methylamino-1,3,4-oxadiazol-2-yl)-

phenyl]imidazo[1,2-a]pyrimidin-3-yl}-(2,6-dimethylphenyl)-

amine

“A17”

2-[3-(2,6-Dichlorophenylamino)imidazo[1,2-a]pyrimidin-2-

yl]-3,5,N-trimethoxybenzamide

“A18”

2-[3-(2,6-Dichlorophenylamino)imidazo[1,2-a]pyrimidin-2-

yl]-3,5-dimethoxybenzohydrazide

“A19”

{2-[2-Chloro-6-(5-methylamino-1,3,4-oxadiazol-2-yl)phenyl]-

imidazo[1,2-a]pyrimidin-3-yl}-(2,6-dimethylphenyl)amine

“A20”

Methyl 3-chloro-2-[3-(2,6-dimethylphenylamino)imidazo-

[1,2-a]pyrimidin-2-yl]benzoate

“A21”

(2,6-Dimethylphenyl)-{2-[4-methoxy-2-(5-methylamino-

1,3,4-oxadiazol-2-yl)phenyl]imidazo[1,2-a]pyrimidin-3-yl}-

amine

“A22”

{2-[2-Chloro-6-(5-methylamino-1,3,4-oxadiazol-2-yl)phenyl]-

imidazo[1,2-a]pyrimidin-3-yl}-(2-chloro-6-methylphenyl)-

amine

“A23”

(2,6-Dichloro-3-methylphenyl)-{2-[2,4-dimethoxy-6-(5-

methylamino-1,3,4-oxadiazol-2-yl)phenyl]imidazo[1,2-a]-

pyrimidin-3-yl}amine

“A24”

2-[3-(2,6-Dichloro-3-methylphenylamino)imidazo[1,2-a]-

pyrimidin-2-yl]-N-ethyl-3,5-dimethoxybenzamide

“A25”

(3,5-Dimethylisoxazol-4-yl)-{2-[2-(5-methylamino-1,3,4-

oxadiazol-2-yl)phenyl]imidazo[1,2-a]pyrimidin-3-yl}amine

“A26”

(2-Chloro-6-methylphenyl)-{2-[2-fluoro-6-(5-methylamino-

1,3,4-oxadiazol-2-yl)phenyl]imidazo[1,2-a]pyrimidin-3-yl}-

amine

“A27”

(4-Fluoro-2,6-dimethylphenyl)-{2-[2-fluoro-6-(5-methyl-

amino-1,3,4-oxadiazol-2-yl)phenyl]imidazo[1,2-a]pyrimidin-

3-yl}amine

or a pharmaceutically usable salt or stereoisomer thereof, including mixtures thereof in all ratios.

2. A medicament composition comprising at least one compound according to claim 1 or a pharmaceutically usable salt or stereoisomer mixture thereof in all ratios, and optionally excipients and/or adjuvants.

3. A method for treating a patient suffering from type 1 or type 2 diabetes comprising administering to said patient a compound according to claim 1 or a pharmaceutically usable salt or stereoisomer thereof.

4. A method of lowering blood sugar in a patient comprising administering to said patient a compound according to claim 1 or a pharmaceutically usable salt or stereoisomer thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 9, 2010
From: KLEIN, MARKUS; MEDERSKI, WERNER; TSAKLAKIDIS, CHRISTOS; BEIER, NORBERT
To: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Reel/Frame 024209/0771 →
Priority Claims (1)
DE 10 2007 048 716 · Oct 11, 2007 · national
Continuity (1)
Related Publication 20100249151A1 · Sep 30, 2010