Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential
A well tolerated oil-in-water emulsion useful as a delivery vehicle of hydrophobic ingredients such as pharmaceutical drugs, wherein the emulsion particles have a net positive charge and comprises 0.001 to 0.1% of a cationic agent, 0 to 1% of a non ionic surfactant and 0 to 0.5% of an anionic surfactant.
1. An oil-in-water emulsion, comprising:
colloid particles having an oily core surrounded by an interfacial film;
said interfacial film having an overall positive charge and comprising, based on total emulsion weight:
1) 0.001 to 0.05% by weight of a cationic agent, said cationic agent being cetalkonium chloride,
2) a non ionic surfactant, said nonionic surfactant being present in an amount up to 1% by weight and consisting of tyloxapol and poloxamer, and
3) 0% by weight of phospholipids; and
said oil core being not higher than 5% weight.
2. The oil-in-water emulsion according to claim 1 , wherein the concentration of the oily core is about 0.5 to 3% w/w.
3. The oil-in-water emulsion according to claim 1 , wherein said colloidal particles have an average particle size of about 0.1 to 1 μm.
4. The oil-in-water emulsion according to claim 3 , wherein said colloidal particles have an average particle size of about 300 nm.
5. The oil-in-water emulsion according to claim 3 , wherein said colloidal particles have an average particle size of about 100 to 200 nm.
6. A pharmaceutical composition comprising a pharmaceutically effective amount of a well tolerated carrier with an active ingredient, said carrier being an oil-in-water emulsion according to claim 1 .
7. The pharmaceutical composition according to claim 6 , wherein said composition is an ophthalmic preparation.
8. The pharmaceutical composition according to claim 6 , wherein the active ingredient is sirolimus.