Compositions for the treatment of hyperphenylalaninemia
The present invention relates to the use of specific types of compounds acting as pharmacological chaperones having a stabilizing activity on the phenylalanine hydroxylase (PAH) enzyme for the prophylaxis and/or treatment of hyperphenylalaninemia (HPA) and phenylketonuria PKU) and diseases, disorders and conditions related thereto. Further, the present invention relates to pharmaceutical compositions containing the compounds according to the present invention as well as to methods of treatment of HPA, in particular, PKU and diseases, disorders and conditions related thereto.
1. A method of treating an individual with hyperphenylalaninemia (HPA), said method comprising:
administering to the individual a pharmacological chaperon having a stabilizing activity on phenylalanine hydroxylase (PAH) enzyme and its physiologically compatible addition salts and solvates, comprising, as an active ingredient,
a compound of formula IV
wherein:
X 3 and X 5 are independently selected from the group of O and S;
X 4 is O, S or NR B ′ wherein R B is selected from the group of H and C 1 to C 6 alkyl;
R 12 and R 13 are independently selected from H, C 1 to C 6 alkyl, aryl, substituted aryl, heterocyclic, or substituted heterocyclic; and
R 14 and R 15 are independently selected from H, C 1 to C 6 alkyl, C 3 to C 6 alkenyl, aryl, substituted aryl, heterocyclic, or substituted heterocyclic.
2. The method according to claim 1 , wherein:
X 3 is O and X 5 is S;
X 4 is O;
R 12 R 13 and R 14 are independently selected from the group of H, C 1 to C 6 alkyl; and
R 15 is selected from the group of aryl, substituted aryl, heterocyclic and substituted heterocyclic.
3. The method according to claim 2 , wherein R 15 is selected from the group of a 6-membered heterocylic ring containing in its backbone 1 or 2 heteroatoms selected from the group consisting of O, S and NR B , wherein R B is as defined above, and containing one or two independent substituents selected from the group consisting of H and C 1 to C 3 alkyl.
4. The method according to claim 1 wherein the compound of formula IV is:
5. The method according to claim 1 , for treating an individual with phenylketonuria (PKU).
6. A pharmaceutical composition comprising a compound of formula IV or its physiologically acceptable acid addition salts or solvates of claim 1 .
7. The pharmaceutical composition according to claim 6 which is a controlled-release pharmaceutical preparation.
8. The pharmaceutical composition according to claim 6 , wherein the composition is further defined as a capsules, tablet, pill, matrix or gel.
9. The pharmaceutical composition according to claim 6 , wherein the active ingredient is released over a time period of greater than six hours during use.
10. The pharmaceutical composition according to claim 6 further defined as a depot formulation.