Precisely-shaped porous particles
Precisely-shaped composites and methods for making these composites are disclosed. The method of this disclosure comprises introducing a precursor composition onto a production tool having at least one continuous surface and a plurality of cavities so as to fill at least a portion of the cavities with the precursor composition and wherein the precursor composition, upon curing, forms a composition having a shape corresponding to the cavities thereby resulting in a plurality of discrete, precisely-shaped particles having a porosity comprising one of the following: (a) 10 m 2 /g or greater or (b) 5 kdalton or greater. The precisely-shaped particles have at least one essentially flat side. The precisely-shaped particles can be confined in a vessel and used for chromatographic applications.
1. An article comprising:
a vessel having an inlet and an outlet and a chromatography medium disposed in the vessel, the chromatography medium comprising a plurality of precisely-shaped particles having (i) at least one essentially flat surface and (ii) a porosity comprising at least one of the following:
(a) 10 m 2 /g or greater or (b) 5 kdalton or greater.
2. An article according to claim 1 , wherein the porosity is 100 m 2 /g or greater.
3. An article according to claim 1 , wherein the porosity is 50 kdalton or greater.
4. An article according to claim 1 , wherein the precisely-shaped particle is derived from a precursor composition, wherein the precursor composition is derived from either an organic material or an inorganic material.
5. An article according to claim 4 , wherein the inorganic material comprises at least one of a silicate, a titanium sol, and a silica sol.
6. An article according to claim 4 , wherein the organic material comprises an ethylenically unsaturated compound.
7. An article according to claim 4 , wherein the precursor composition further comprises a porogen.
8. An article according to claim 7 , wherein the porogen comprises at least one of an alcohol, an ethylene glycol, polyethyleneglycol, and a propylene glycol.
9. An article according to claim 1 , wherein the precisely-shaped particles comprise a functional group.
10. An article according to claim 9 , wherein the functional group is at least one of an affinity ligand, a cation, an anion, and a hydrophobic ligand.
11. An article according to claim 1 , wherein the precisely-shaped particles are substantially uniform in size.
12. An article according to claim 1 , wherein the precisely-shaped particles are uniform in shape.
13. An article according to claim 11 , wherein the precisely-shaped particles are uniform in shape.
14. An article according to claim 1 , wherein the plurality of precisely-shaped particles comprise a distribution of two or more shapes.
15. An article according to claim 1 , wherein the plurality of precisely-shaped particles comprise a distribution of two or more substantially uniform sizes.
16. An article according to claim 1 , wherein the vessel is a tube.
17. An article according to claim 4 , wherein the organic material comprises a polysaccharide.
18. An article according to claim 4 , wherein the precursor composition is substantially free of a porogen.
19. A method of separating comprising:
providing a chromatography medium comprising a plurality of precisely-shaped particles having (i) at least one essentially flat surface and (ii) a porosity comprising at least one of the following: (a) 10 m 2 /g or greater or (b) 5 kdalton or greater;
contacting the chromatography medium with a liquid mixture; and
separating the mixture.