Compositions and methods for treating hyperproliferative diseases
View Patent ↗The invention relates to a composition that includes a first agent selected including an agent that possesses anti-inflammatory activity or acetaminophen, phenacetin, tramadol and the like; a second agent selected from the group consisting of an oxidative phosphorylation inhibitor, an ionophore, and an adenosine 5-monophosphate-activated Protein kinase (AMPK) activator; a third agent that possesses or maintains serotonin activity.
1. A method for treating cancer, consisting essentially of administering to a subject in need thereof an effective amount of a composition consisting essentially of a first agent selected from the group consisting of aspirin and celecoxib; a second agent that is metformin; and a third agent that possesses or maintains serotonin activity that is serotonin creatinine sulfate complex.
2. The method of claim 1 , wherein the cancer is a malignant tumor.
3. The method of claim 1 , wherein the cancer is a solid tumor.
4. The method of claim 1 , wherein the composition consists essentially of 1-5000 mg of the first agent, 5-5000 mg of the second agent, and 0.1-1000 mg of the third agent.
5. The method of claim 1 , wherein the composition further consists essentially of a pharmaceutically acceptable carrier.
6. A method for treating cancer, consisting essentially of administering to a subject in need thereof an effective amount of a composition consisting essentially of:
(a) a first agent that possesses anti-inflammatory activity, wherein the first agent is celecoxib;
(b) a second agent that is an 5′-monophosphate-activated protein kinase (AMPK) activator, wherein the second agent is metformin; and
(c) a third agent that possesses or maintains serotonin activity, wherein the third agent is serotonin creatinine sulfate complex.
7. A method for treating cancer, consisting essentially of administering to a subject in need thereof an effective amount of a composition consisting essentially of:
(a) a first agent that possesses anti-inflammatory activity, wherein the first agent is aspirin;
(b) a second agent that is an 5′-monophosphate-activated protein kinase (AMPK) activator, wherein the second agent is metformin; and
(c) a third agent that possesses or maintains serotonin activity, wherein the third agent is serotonin creatinine sulfate complex.