IP Library › Granted Patent US 8,377,968
Granted Patent B2
US 8,377,968 · App. 12/420,793 · Granted Feb 19, 2013

N-piperidinyl acetamide derivatives as calcium channel blockers

Inventors: Hassan Pajouhesh (West Vancouver, CA); Ramesh Kaul (Burnaby, CA); Yanbing Ding (Richmond, CA); Yongbao Zhu (Langley, CA); Lingyun Zhang (Vancouver, CA); Nagasree Chakka (Cambridge, MA); Mike Grimwood (North Vancouver, CA); Jason Tan (Vancouver, CA); Yuanxi Zhou (Richmond, CA)
Assignee: Zalicus Pharmaceuticals, Ltd.
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Quick Facts
Patent No.
US 8,377,968
App. No.
12/420,793
Granted
Feb 19, 2013
Kind
B2
Abstract

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).

Claims (3)

1. A pharmaceutical composition comprising a compound having the structure:

or a pharmaceutically acceptable salt or conjugate thereof in admixture with a pharmaceutically acceptable excipient.

2. A method to treat epilepsy, said method comprising administering to a subject in need of such treatment an amount of the pharmaceutical composition of claim 1 effective to ameliorate epilepsy.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 7, 2018
From: TARO PHARMACEUTICALS INC.
To: MARK G. DEGIACOMO, CHAPTER 7 TRUSTEE OF EPIRUS BIOPHARMACEUTICALS, INC.
Reel/Frame 047435/0416 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 7, 2018
From: MARK G. DEGIACOMO, CHAPTER 7 TRUSTEE OF EPIRUS BIOPHARMACEUTICALS, INC.
To: PRAXIS PRECISION MEDICINES, INC.
Reel/Frame 047445/0370 →
MERGER Recorded Mar 24, 2016
From: ZALICUS PHARMACEUTICALS LTD.
To: TARO PHARMACEUTICALS INC.
Reel/Frame 038091/0087 →
CHANGE OF NAME Recorded Sep 15, 2010
From: NEUROMED PHARMACEUTICALS LTD.
To: ZALICUS PHARMACEUTICALS LTD.
Reel/Frame 024990/0430 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 10, 2009
From: PAJOUHESH, HASSAN; KAUL, RAMESH; DING, YANBING; ZHU, YONGBAO; ZHANG, LINGYUN; CHAKKA, NAGASREE; GRIMWOOD, MIKE; TAN, JASON; ZHOU, YUANXI
To: NEUROMED PHARMACEUTICALS LTD.
Reel/Frame 022806/0001 →
Continuity (2)
Provisional Application 61058179 · Jun 2, 2008
Related Publication 20090298883A1 · Dec 3, 2009