Bioadhesive constructs
The invention describes substrates, such as prosthetics, films, nonwovens, meshes, etc. that are treated with a bioadhesive. The bioadhesive includes polymeric substances that have phenyl moieties with at least two hydroxyl groups. The bioadhesive constructs can be used to treat and repair, for example, hernias and damaged tendons.
1. A bioadhesive construct, comprising:
a support; and
a coating comprising a multihydroxyphenyl (DHPD) functionalized polymer (DHPp) wherein the functionalized DHPp comprises the formula:
CA-[Z-PA-(L) a -(DHPD) b ] n
wherein
CA is a central atom that is carbon;
each Z, independently, is a C1 to a C6 linear or branched, substituted or unsubstituted alkyl group or a bond;
each PA, independently, is a substantially poly(ethylene oxide) polyether;
each L, independently, is a succinamic acid linker wherein an ester group links said succinamic acid linker to said PA and wherein an amide group links said succinamic acid linker to said DHPD;
each DHPD, independently is a multihydroxy phenyl;
“a” has a value of a value of 1;
“b” has a value of 1; and
“n” has a value of 4.
2. The bioadhesive construct of claim 1 , further comprising an oxidant.
3. The bioadhesive construct of claim 1 , wherein the oxidant is formulated with the coating.
4. The bioadhesive of claim 2 , wherein the oxidant is applied to the coating.
5. The bioadhesive construct of claim 1 , wherein the support is a film, a mesh, a membrane, or a prosthetic.
6. The bioadhesive construct of claim 4 , wherein the support is a film, a mesh, a membrane, or a prosthetic.
7. The bioahesive construct of claim 1 , wherein the construct is hydrated.
8. The bioadhesive construct of claim 4 , wherein the construct is hydrated.