Substituted N-aryl pyridinones
Disclosed herein are substituted N-Aryl pyridinone fibrotic inhibitors and/or collagen infiltration modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
1. A compound having the structural formula:
or a pharmaceutically acceptable salt thereof.
2. The compound as recited in claim 1 , wherein each of said positions represented as D has deuterium enrichment of at least 98%.
3. The compound as recited in claim 1 , wherein each of said positions represented as D has deuterium enrichment of at least 90%.
4. The compound as recited in claim 1 , wherein each of said positions represented as D has deuterium enrichment of at least 50%.
5. The compound as recited in claim 1 , wherein each of said positions represented as D has deuterium enrichment of at least 20%.
6. The compound as recited in claim 1 , wherein each of said positions represented as D has deuterium enrichment of at least 10%.
7. The compound as recited in claim 1 , wherein each of said positions represented as D has deuterium enrichment of at least 5%.
8. The compound as recited in claim 1 , wherein each of said positions represented as D has deuterium enrichment of at least 1%.
9. A pharmaceutical composition comprising the compound as recited in claim 1 and one or more pharmaceutically acceptable carriers.