Methods and compositions using immunomodulatory compounds for the treatment of immunodeficiency disorders
Methods of treating, preventing and/or managing an immunodeficiency disease or disorder are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active agent. Methods of boosting humoral immunity are also disclosed.
1. A method of treating or managing an immunodeficiency disease or disorder, which comprises administering to a patient in need of such treatment or management a therapeutically effective amount of an immunomodulatory compound of formula (I),
or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof,
wherein one of X and Y is C═O, the other of X and Y is C═O or CH2 , and R2 is hydrogen or lower alkyl; and
wherein the immunodeficiency disease or disorder is adenosine deaminase deficiency, antibody deficiency with normal or elevated Igs, ataxia-telangiectasia, bare lymphocyte syndrome, common variable immunodeficiency, Ig deficiency with hyper-IgM, Ig heavy chain deletions, IgA deficiency, immunodeficiency with thymoma, reticular dysgenesis, Nezelof syndrome, selective IgG subclass deficiency, transient hypogammaglobulinemia of infancy, Wiskott-Aldrich syndrome, X-linked agammaglobulinemia, or X-linked severe combined immunodeficiency.
2. The method of claim 1 , wherein the immunodeficiency disease or disorder is primary immunodeficiency or secondary immunodeficiency.
3. The method of claim 2 , wherein the immunodeficiency disease or disorder is primary immunodeficiency.
4. The method of claim 1 , wherein the immunodeficiency disease or disorder is X-linked agammaglobulinemia.
5. The method of claim 1 , wherein the immunomodulatory compound is 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione.
6. The method of claim 5 , wherein the immunomodulatory compound is enantiomerically pure.
7. The method of claim 1 , wherein the immunomodulatory compound is 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione.
8. The method of claim 7 , wherein the immunomodulatory compound is enantiomerically pure.
9. The method of claim 1 , further comprising administering an anti-CD40 antibody to said patient.
10. The method of claim 1 , further comprising administering CD40L to said patient.