3-substituted propanamine compounds
Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I): or a pharmaceutically acceptable salt thereof are disclosed. Pharmaceutical compositions containing the subject compounds are also disclosed. The subject compounds are useful for the treatment of diseases of the central nervous system, such as depression, anxiety and pain disorders.
1. A method of treating depression, anxiety and pain disorders in a mammal in need of such treatment which comprises administering to said mammal an effective amount of a racemic or enantiomerically enriched 3-substituted propanamine compound represented by the following structural formula (I):
or a pharmaceutically acceptable salt thereof, wherein;
A is selected from the group consisting of phenyl, naphthyl and benzodioxolyl which can be substituted with one or more identical or different substituents selected from the group consisting of hydrogen, halogen, straight- or branched-chain alkyl of from 1 to 4 carbon atoms, straight- or branched-chain alkoxy of from 1 to 3 carbon atoms, phenyl, phenyloxy, nitro, cyano, trifluoromethyl, trifluoromethoxy, methanesulfonyl and thienyl;
R 1 and R 2 are same or different and independently selected from the group consisting of hydrogen, lower alkyl of from 1 to 4 carbon atoms, substituted or unsubstituted phenyl-C 1-4 alkyl or R 1 and R 2 are fused with nitrogen atom to form a cyclic group which has 4 to 7 carbon atoms;
R 3 , R 4 , R 5 and R 6 are same or different and independently selected from the group consisting of hydrogen, lower alkyl of from 1 to 4 carbon atoms and substituted or unsubstituted phenyl;
B is selected from the group consisting of an azole as represented by the following structural formulae (II):
2. A method of treating depression, anxiety and pain disorders in a mammal in need of such treatment which comprises administering to said mammal an effective amount of a racemic or enantiomerically enriched 3-substituted propanamine compound in accordance with claim 1 wherein A, B, R 1 and R 2 are as defined therein and each of R 3 through R 6 is hydrogen, said compound being represented by the following structural formula (III):
3. A method of treating depression, anxiety and pain disorders in a mammal in need of such treatment which comprises administering to said mammal an effective amount of a racemic or enantiomerically enriched 3-substituted propanamine compound in accordance with claim 1 wherein A and B are as defined therein, each of R 3 through R 6 is hydrogen and one of R 1 and R 2 is hydrogen and the other is methyl, said compound being represented by the following structural formula (XI):