Manufacturing method of foldable artificial vitreous body and mould thereof
The present invention relates to a foldable capsular vitreous body (FCVB), and its mold design, method for manufacturing, product appearance, and drug delivery property and so on. A mold for molding a foldable artificial vitreous body comprises an upper mold ( 1 ), a lower mold ( 2 ) and a core ( 3 ). The core ( 3 ) is disposed between the upper mold ( 1 ) and the lower mold ( 2 ) and is connected with a drainage-tube pin connected with an injection channel ( 4 ). Heating holes ( 6 ) are disposed in the upper mold ( 1 ) and/or the lower mold ( 2 ). Material is injected to the mold and is heated to vulcanize to mold vitreous body. The FCVB is adapted to be injected with any harmless medium and can be used as a delivery vehicle inside or around the eye ball. The size or shape of the FCVB can be changed depending on the different implant site.
1. A method for manufacturing a foldable artificial vitreous body by injection of processing material into a mould using injection molding technology, so as to form a folded artificial vitreous body, the method comprising:
(1) mixing evenly natural or modified macromolecule materials, vacuumizing and setting aside the mixture of natural or modified macromolecule materials;
(2) coating a proper amount of processing material on a drainage valve and laying a hard sheet;
(3) putting a core into a mould, which includes putting the core between an upper mould and a lower mould of the mould, closing and locking the upper and lower moulds;
(4) injecting the mixture of natural or modified macromolecule materials obtained in step (1) through a plastic injection channel and into a mould cavity formed by the upper and lower moulds;
(5) heating the mould via heating holes and solidifying the material injected in step (4) in the mould cavity;
(6) opening the mould, taking out the core after cooling, and peeling out a capsular bag.
2. The method according to claim 1 , further comprising coating a proper amount of processing material on a peeling opening of the capsular bag obtained in step (6), putting the capsular bag in a sealing device which matches with the peeling opening of the capsular bag, and trimming the peeling opening by a trimmer after agglutination.
3. The method according to claim 2 , wherein a working temperature range of the sealing device is 60° C.-300° C., and a working time of the sealing device is more than 2 seconds.
4. The method according to claim 1 , further comprising coating a proper amount of diluted processing material seated on the peeling opening of the capsular bag obtained in step (6), and vulcanizing and sealing the peeling opening of the capsular bag; or coating a proper amount of normal temperature solidified gel material to seal the peeling opening.
5. The method according to claim 1 , wherein a heating temperature in step (5) is within 80° C.-300° C.
6. The method according to claim 1 , wherein the processing material is selected from the group consisting of polysiloxane, polyurethane, styrene triblock copolymer thermoplastic elastomers, hydroxyethyl methacrylate (HEMA), polyvinyl alcohol (PVA), poly(lactide-co-glycolide (PLGA) and hyaluronic acid ester.
7. The method according to claim 6 , further comprising adding hydroxy-containing hydrophilic groups into the processing material to control water rate in the capsular bag such that the water rate is 5-30%.
8. The method according to claim 6 , further comprising adding fluoro group-containing materials into the processing material to increase oxygen permeability of the capsular bag.
9. The method according to claim 1 , wherein the processing material uses absorbable material to enable the foldable artificial vitreous body to be absorbed slowly after implantation during disease treatment.
10. The method according to claim 1 , further comprising diluting the processing material to alter the physical state of the processing material.
11. The method according to claim 1 , further comprising controlling a permeability of the capsular bag by changing an aperture of the capsular bag, a wall thickness of the capsular bag, osmotic pressure of a medium in the capsular bag, or by using nanotechnology, or by injecting via the drainage valve a therapeutic drug, nutritional factors, or a natural vitreous effective composition to make the capsular bag a sustained drug delivery system.
12. The method according to claim 1 , further comprising connecting the plastic injection channel with a number of cores simultaneously for batch production.
13. The method according to claim 1 , further comprising cleaning the upper and lower moulds.