Copolymers for intraocular lens systems
Some embodiments provide a copolymer comprising: an acrylate recurring unit and an optionally substituted vinylaryl recurring unit, wherein a portion of at least one of the recurring units comprises a vinyldialkylsiloxy pendant group. The copolymers may be useful as soft acrylic haptics for intraocular lenses. Some embodiments further relate to intraocular lenses having a hydrophobic soft acrylic optic and a silicone haptic, such as a dual optic accommodative lens a having hydrophobic soft acrylic anterior and posterior optic bodies and a silicone haptic. Related copolymeric composite materials as well as additional embodiments of intraocular lenses, are also described herein.
1. An intraocular lens comprising:
an optic body comprising a first hydrophobic soft acrylic copolymer; and
a haptic comprising a first silicone connected to the optic body;
wherein the first hydrophobic soft acrylic copolymer comprises:
an acrylate recurring unit; and
an optionally substituted vinylaryl recurring unit;
wherein a portion of at least one of the recurring units comprises a vinyldialkylsiloxy pendant group, and further wherein the first hydrophobic soft acrylic copolymer is prepared by a process comprising reacting
monomer 1a, monomer 2, and monomer 3a; and
monomer 4 or monomer 5a;
wherein monomer 1a represents about 20% to about 70% of the total weight of all monomers present in the process and is represented by a formula:
monomer 2 represents about 10% to about 40% of the total weight of all monomers present in the process and is represented by a formula:
monomer 3a represents about 5% to about 40% of the total weight of all monomers present in the process and is represented by a formula:
monomer 4 is represented by a formula:
monomer 5a represents about 1% to about 20% of the total weight of all monomers present in the process and is represented by a formula:
R 1 and R 2 are independently C 1-12 alkyl or optionally substituted phenyl;
X is C 1-4 alkyl;
Y 1 , Y 2 , and Y 3 are independently H or C 1-4 alkyl;
Ph 1 and Ph 2 are independently optionally substituted phenyl;
each R 3 and each R 4 is independently C 1-4 alkyl or
each R 5 and each R 6 is independently C 1-4 alkyl;
R 7 is a covalent bond or C 1-6 alkyl; and
R 8 is C 1-6 alkyl.
2. The intraocular lens of claim 1 , wherein the optic body consists essentially of the hydrophobic soft acrylic copolymer.
3. The intraocular lens of claim 1 , wherein a portion of the optic body is the hydrophobic soft acrylic copolymer.
4. The intraocular lens of claim 3 , wherein the optic body further comprises a second silicone.
5. The intraocular lens of claim 1 , which is a dual optic accommodative lens comprising:
an anterior optic body comprising the first hydrophobic soft acrylic copolymer;
a posterior optic body comprising a second hydrophobic soft acrylic copolymer; and
a haptic comprising the first silicone connecting the anterior optic body to the posterior optic body.
6. The intraocular lens of claim 1 , which is a dual optic accommodative lens comprising:
an anterior optic body comprising the first hydrophobic soft acrylic copolymer;
a posterior optic body comprising a second silicone; and
wherein the haptic is also connected to the posterior optic body.
7. The intraocular lens of claim 1 , which is a dual optic accommodative lens comprising:
an anterior optic body comprising a second silicone;
a posterior optic body comprising the first hydrophobic soft acrylic copolymer; and
wherein the haptic is also connected to the posterior optic body.