Method for treating ocular demodex
The present invention relates to a method for treating a disorder chosen from ocular Demodex, Demodex -induced blepharitis, rosacea, acne, and meibomian gland dysfunction in a patient in need thereof, comprising administering to the patient a composition comprising a therapeutically effective amount of a substance chosen from at least one of an isoprenoidal essential oil such as Tea Tree Oil; Terpinen-4-ol; Carvone; alpha-Terpineol; Cardinene; d-Carvone; l-Carvone; gamma-Terpinene; alpha-Terpinene; 1,8-Cineole; alpha-Terpineol; para-Cimene; alpha-Pinene; Limonene; (R)-(+)-Limonene; alpha-Thugene; Eucalyptol; (+)-Ledene; Cuminic Aldehyde; and Myrcene; the administration comprising contacting or scrubbing an affected area of skin or hair, or eyelid margin and lashes of the patient with the composition; also disclosed are a method for treating mange and mite infestations on a mammalian animal; and kits for in-office and at home treatments of the disorders.
1. A method of treating an ocular Demodex infestation or Demodex -induced blepharitis in an individual in need thereof, comprising administering to the individual a therapeutically-effective amount of a composition consisting essentially of terpinen-4-ol as an active agent and at least one pharmaceutically-acceptable excipient.
2. The method of claim 1 , comprising administering the composition topically.
3. The method of claim 1 , comprising administering the composition to the eyelid margin and eyelash.
4. The method of claim 1 , further comprising scrubbing the eyelid margin and eyelash roots with the composition.
5. The method of claim 1 , wherein the composition is a shampoo, gel, solution or suspension.
6. The method of claim 1 , wherein the pharmaceutically-acceptable excipient is selected from water, saline, a lubricant, dextrose, ethanol, or any combination thereof.
7. The method of claim 6 , wherein the pharmaceutically-acceptable excipient is selected from corn oil, olive oil, glycerol, and petroleum jelly.
8. The method of claim 1 , comprising administering the composition weekly for at least 4 weeks.
9. The method of claim 1 , comprising administering a first dose of the composition weekly and a second dose of the composition daily.
10. The method of claim 1 , comprising administering the composition twice daily for one month, then administering the composition daily.
11. The method of claim 1 , comprising administering the composition for at least 3 minutes, for at least 4 minutes, for at least 5 minutes, for at least 10 minutes, or for at least 15 minutes.
12. The method of claim 1 , wherein the individual is refractory to an anti-inflammatory, conventionally anti-microbial antibiotic, or an anti-allergy therapy for ocular Demodex infestation or Demodex -induced blepharitis.