IP Library › Granted Patent US 8,440,443
Granted Patent B1
US 8,440,443 · App. 11/749,550 · Granted May 14, 2013

MEK1 polypeptides

Inventors: Thierry O. Fischmann (Scotch Plains, NJ); Hung V. Le (Rockaway, NJ); Vincent S. Madison (Mountain Lakes, NJ); Anthony F. Mannarino (North Plainfield, NJ); Todd W. Mayhood (Randolph, NJ); Paul Reichert (Montville, NJ); Catherine Smith (Union, NJ); Tin-Yau Chan (Edison, NJ)
Assignee: Merck Sharp & Dohme Corp.
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Quick Facts
Patent No.
US 8,440,443
App. No.
11/749,550
Granted
May 14, 2013
Kind
B1
Abstract

The present invention provides, inter alia, crystals of the MEK1 polypeptide which are particularly useful for structure based drug design as well as methods of use thereof.

Claims (4)

1. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:1, the amino acid sequence of SEQ ID NO:2, the amino acid sequence of amino acids 25-383 of SEQ ID NO: 1, or the amino acid sequence of amino acids 25-373 of SEQ ID NO:2.

2. The polypeptide of claim 1 comprising the amino acid sequence of SEQ ID NO: 1 or the amino acid sequence of SEQ ID NO: 2.

3. A composition comprising the polypeptide of claim 1 .

4. An isolated fusion protein comprising the polypeptide of claim 1 fused to a heterologous protein.

Assignments (2)
CHANGE OF NAME Recorded Jan 31, 2013
From: SCHERING CORPORATION
To: MERCK SHARP & DOHME CORP.
Reel/Frame 029732/0059 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 30, 2007
From: FISCHMANN, THIERRY O.; LE, HUNG V.; MADISON, VINCENT S.; MANNARINO, ANTHONY F.; REICHERT, PAUL; SMITH, CATHERINE; CHAN, TIN-YAU; MAYHOOD, TODD W.
To: SCHERING CORPORATION
Reel/Frame 019619/0833 →
Continuity (1)
Provisional Application 60800876 · May 16, 2006