Inhibitors of human immunodeficiency virus replication
Compounds of formula (I): wherein c, X, Y, R 2 , R 4 and R 5 are defined herein, are useful as inhibitors of HIV replication.
1. A compound of the formula (I)
wherein
------- represents either a single or double bond;
X is N when Y is N—R 7 ; or
X is N—R 6 when Y is N;
R 2 is (C 1-4 )alkyl;
R 5 is H or (C 1-4 )alkyl;
R 6 is (C 1-6 )alkylene-phenyl or (C 1-6 )alkylene-pyridinyl, wherein said phenyl and pyridinyl are optionally substituted with 1 to 2 substituents each independently selected from (C 1-6 )alkyl, —O(C 1-6 )alkyl, and —O(C 1-6 )haloalkyl;
R 7 is H, (C 1-6 )alkyl, (C 1-6 )alkylene-O(C 1-6 )alkyl, (C 1-6 )alkylene-O-aryl, (C 1-6 )haloalkyl, (C 1-6 )alkylene-(C 3-7 )cycloalkyl, (C 1-6 )alkylene-Het or (C 1-6 )alkylene-aryl, wherein said (C 1-6 )alkylene-Het and (C 1-6 )alkylene-aryl are optionally substituted with (C 1-6 )alkyl, —O(C 1-6 )alkyl, or —O(C 1-6 )haloalkyl, and wherein Het is selected from:
R 3 is —O(C 1-4 )alkyl, and bond c is a single bond;
R 4 is phenyl or Het, wherein said phenyl and Het are optionally substituted with 1 to 3 substituents each independently selected from halo, (C 1-6 )alkyl, and -O(C 1-6 ) alkyl, and wherein Het is selected from:
or a salt thereof.
2. A compound according to claim 1 having the formula (Ib) or a pharmaceutically acceptable salt thereof:
wherein R 2 , R 3 , R 4 , R 5 and R 7 are as defined in claim 1 .
3. A compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is —CH 3 or —CH 2 CH 3 .
4. A pharmaceutical composition comprising a compound according to any one of claim 1 , 2 or 3 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
5. A method for treating HIV infection in a host infected by HIV which method comprises administering to said host a therapeutically effective amount of a compound according to any one of claim 1 , 2 or 3 or a pharmaceutically acceptable salt thereof.