3-methanesulfonylpropionitrile for treating inflammation and pain

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a purified compound of 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof:

wherein the compound has at least 90% (w/w) purity, and the composition is in a topical form of gels, creams, lotions, or patches.

2. The pharmaceutical composition of claim 1 , wherein the compound is at least 95% (w/w) pure.

3. The pharmaceutical composition according to claim 1 , the compound is in an amount of about 0.5-10% (w/w).

4. The pharmaceutical composition of claim 1 , wherein the compound is at least 98% (w/w) pure.

5. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, wherein the pharmaceutically acceptable carrier is an emollient selected from the group consisting of: lauryl lactate, diethylene glycol monoethylether, caprylic/capric triglyceride, octisalate, silicone fluid, Squalene, and sunflower oil.

6. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, wherein the pharmaceutically acceptable carrier is a permeation enhancer selected from the group consisting of lactate esters and diethylene glycol monoethylether.

7. The pharmaceutical composition according to claim 6 , wherein the permeation enhancer is diethylene glycol monoethylether.

8. The pharmaceutical composition according to claim 6 , further comprising acrylates/C10-30 alkyl and tris(2-hydroxyethyl)amine.