Methods and compositions for diagnosing and treating diseases
Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.
1. A method of inhibiting proliferation of gastric cancer cells that express an SLC5A6 protein, the method comprising contacting the gastric cancer cells with an antibody that selectively binds to the SLC5A6 protein to thereby inhibit proliferation of the gastric cancer cells, wherein the amino acid sequence of the SLC5A6 protein comprises a sequence selected from the group consisting of SEQ ID NOS:7-9, and wherein the antibody is coupled to at least one agent selected from the group consisting of drugs, toxins, differentiation inducers, and radionuclides.
2. The method of claim 1 , wherein said contacting comprises administering a therapeutically effective amount of the antibody to an individual harboring the gastric cancer cells.