Anti-VEGF-C antibodies and methods using same
The invention provides VEGF-C antagonists, such as anti-VEGF-C antibodies, and their use in the prevention and treatment of tumor progression.
1. An isolated anti-vascular endothelial growth factor-C (VEGF-C) antibody, wherein the antibody comprises six HVRs:
(1) an HVR-H1 comprising the amino acid sequence of SEQ ID NO:3;
(2) an HVR-H2 comprising the amino acid sequence of SEQ ID NO:8;
(3) an HVR-H3 comprising the amino acid sequence of SEQ ID NO:26;
(4) an HVR-L1 comprising the amino acid sequence of SEQ ID NO:27;
(5) an HVR-L2 comprising the amino acid sequence of SEQ ID NO:28; and
(6) an HVR-L3 comprising the amino acid sequence of SEQ ID NO:29.
2. The antibody of claim 1 , wherein the antibody further comprises an Fc having an amino acid substitution at position 297 to alanine.
3. The antibody of claim 2 , wherein the Fc further comprises an amino acid substitution at position 265 to alanine.
4. The antibody of claim 1 , wherein the antibody is a monoclonal antibody.
5. The antibody of claim 1 , wherein the antibody is a humanized antibody.
6. The antibody of claim 1 , wherein the antibody is a bispecific antibody.
7. The antibody of claim 1 , comprising a heavy chain variable domain (VH) and a light chain variable domain (VL), wherein said VL comprises the amino acid sequence of SEQ ID NO:85.
8. The antibody of claim 7 , wherein said VH comprises the amino acid sequence of SEQ ID NO:84.