Treatment of migraine headache with diffusion of toxin in non-muscle related areas of the head
View Patent ↗A method for treating a patient with migraine headache in accordance with the present invention generally includes administering to the patient a therapeutically effective amount of a Botulinum toxin in a pharmaceutically safe form with the administration being on the trigeminal cervical system, for enabling axonal transport of the neurotoxin from distal to central sites. More specifically, the administration includes extramuscular injection of the neurotoxin over the aponeurotic fascia of the scalp for enabling the neurotoxin to diffuse into distal sensory nerves, in order to enable concentration over the occipital-parietal-frontal head region.
1. A method for treating a human patient with migraine headache, said method comprising administering to the patient a therapeutically effective amount of diluted Botulinum toxin in a pharmaceutically safe form wherein said diluted Botulinum toxin is about 4-10 cc normal saline per 100 units of Botulinum toxin, said administration comprising extramuscular injection into one or more of the frontal, parietal and occipital aponeurotic fascia in the scalp.
2. The method according to claim 1 wherein the Botulinum toxin is Botulinum toxin A.
3. The method according to claim 1 wherein the Botulinum toxin is Botulinum toxin B.
4. The method according to claim 1 wherein the Botulinum toxin is an endopeptidase derived from Botulinum toxin.
5. The method according to claim 2 wherein the Botulinum toxin A is onabotulinumtoxinA.