Injectable water-in-oil emulsions
Personal care or cosmetic oil in water emulsions include an oil emulsifier and a combination of a Xanthan polysaccharide and a polyglucomannan polysaccharide to provide enhanced stability even at low emulsifier stabilizer levels. The emulsifier stabilizer system provides stable emulsions without dominating system rheology, particularly viscosity. Thus, the emulsions can have a low viscosity suitable for formulation as milks or thin lotions, or can be thickened, desirably by thickening agents other than the Xanthans and/or polyglucomannan, to provide emulsion creams or gels. This enables the system to be used very flexibly in end use applications. The emulsifier is desirably a non-ionic emulsifier and particularly is a combination of a low HLB and a high HLB emulsifier and can be formulated with conventional alcohol ethoxylate surfactants or from non-EO surfactants e.g. sucrose ester high HLB surfactants and citrate or sorbitan ester low HLB surfactants.
1. An injectable, immunogenic adjuvant composition comprising a water-in-oil emulsion, wherein said emulsion comprises a vaccine antigen and a polymeric emulsifier, which is a block copolymer having a general formula A-COO-B-OOC-A, in which component B is the divalent residue of a water-soluble polyalkylene glycol and components A are the residue of an oil-soluble complex monocarboxylic acid, said emulsion having a viscosity below 450 mPas.
2. The adjuvant composition according to claim 1 , characterized in that components A have a molecular weight of at least 500 and component B has a molecular weight of at least 500.
3. An adjuvant according to claim 1 , characterized in that component B is derived from polyethylene glycol and components A are derived from polyhydroxystearic acid.
4. An adjuvant according to claim 1 , characterized in that the polymeric emulsifier is a block copolymer of polyethylene glycol and polyhydroxystearic acid.
5. An adjuvant according to claim 1 , characterized in that the emulsion comprises 0.01-15% w/w of the polymeric emulsifier.
6. An adjuvant according to claim 5 , characterized in that the emulsion comprises 0.3-0.5% w/w of the polymeric emulsifier.
7. An adjuvant according to claim 1 , characterized in that the oil is a metabolisable oil.
8. An adjuvant according to claim 7 , characterized in that the oil is a semi-synthetic oil, or oleyl oleate.
9. An injectable, immunogenic adjuvant composition, comprising a water-in-oil-in water (w/o/w) emulsion, wherein said (w/o/w) emulsion is based on a water-in-oil emulsion comprising a vaccine antigen and a polymeric emulsifier which is a block copolymer having a general formula A-COO-B-OOC-A, in which component B is the divalent residue of a water-soluble polyalkylene glycol and components A are the residue of an oil-soluble complex monocarbxylic acid, said emulsion having a viscosity below 450 mPas.
10. The composition of claim 1 , wherein the emulsion has a viscosity below 250 mPas.
11. The composition of claim 1 , wherein the emulsion has a viscosity below 100 mPas.
12. The injectable adjuvant composition of claim 1 , wherein the water-in-oil emulsion comprises water droplets of a size between about 1 and 5 micrometers.
13. The injectable adjuvant composition of claim 9 , wherein the water-in-oil emulsion comprises water droplets of a size between about 1 and 5 micrometers.