Granted Patent
B2
US 8,497,365 · App. 13/198,403 · Granted Jul 30, 2013
Cyclodextrin-based polymers for therapeutics delivery
Inventors:
Mark E. Davis (Pasadena, CA); Jungyeon Hwang (Lexington, MA); Tianyi Ke (Arcadia, CA); Ching-Jou Lim (San Diego, CA); Thomas Schluep (La Crescenta, CA)
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Abstract
The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein.
Claims (3)
1. A polymer conjugate comprising a subunit of the following formula
wherein
has a molecular weight of 3.4 kDa.
Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 24, 2013
From: DAVIS, MARK E.; KE, TIANYI; HWANG, JUNGYEON; LIM, CHING-JOU; SCHLUEP, THOMAS
To: INSERT THERAPEUTICS, INC.
Reel/Frame 030671/0837 →
CHANGE OF NAME
Recorded Jun 24, 2013
From: INSERT THERAPEUTICS, INC
To: CALANDO PHARMACEUTICALS, INC.
Reel/Frame 030671/0904 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 24, 2013
From: CALANDO PHARMACEUTICALS, INC.
To: CERULEAN PHARMA INC.
Reel/Frame 030671/0967 →
Continuity (4)
Provisional Application
60897096
· Jan 24, 2007
Provisional Application
61002752
· Nov 9, 2007