Pharmaceutical compositions containing botulinum neurotoxin
This invention relates to the use of a composition comprising a polysaccharide and a botulinum toxin for reducing a skin wrinkle. In some embodiments, the polysaccharide comprises disaccharides. In some embodiments, the average molecular weight of a disaccharide unit of the polysaccharide is between about 345 D and about 1,000 D.
1. A pharmaceutical composition comprising a collagen and a botulinum toxin, wherein the pharmaceutical composition is albumin free.
2. The pharmaceutical composition of claim 1 , wherein the botulinum toxin is selected from the group consisting of botulinum toxin types A, B, C 1 , D, E, F and G.
3. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition has a pH of between about 5 and 7.3 when reconstituted or upon injection.
4. The pharmaceutical composition of claim 1 , wherein the botulinum toxin comprises a botulinum toxin complex.
5. The pharmaceutical composition of claim 4 , wherein the botulinum toxin complex comprises a botulinum toxin complex type A.
6. The pharmaceutical composition of claim 4 , wherein the botulinum toxin complex comprises a botulinum toxin complex type B.