Delivery of micro- and nanoparticles with blood platelets
The invention is directed to platelets containing micron or nanometer size particles wherein the micron or nanometer sized particles comprises an active agent. The invention is also directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the above platelets. The invention is further directed to methods of delivering the micron or nanometer size particles containing an active agent to a site of interest in a patient.
1. Platelets containing super-paramagnetic iron oxide nanoparticles.
2. The platelets of claim 1 , wherein said platelets comprise mammalian blood platelets.
3. The platelets of claim 1 , wherein said platelets comprise human blood platelets.
4. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and platelets containing super-paramagnetic iron oxide nanoparticles.
5. The pharmaceutical composition of claim 4 , wherein said platelets comprise mammalian blood platelets.
6. The pharmaceutical composition of claim 4 , wherein said platelets comprise human blood platelets.
7. The pharmaceutical composition of claim 4 , wherein said carrier is a sterile carrier.
8. The pharmaceutical composition of claim 4 , wherein said carrier is a solid carrier.
9. The pharmaceutical composition of claim 4 , wherein said carrier is a liquid carrier.
10. The pharmaceutical composition of claim 4 , wherein said carrier is an aqueous carrier.
11. The platelets of claim 1 , wherein said platelets are fresh.
12. The platelets of claim 1 , wherein said platelets are rehydrated-lyophilized.
13. The pharmaceutical composition of claim 4 , wherein said platelets are fresh.
14. The pharmaceutical composition of claim 4 , wherein said platelets are rehydrated-lyophilized.