Substituted hydroxamic acids and uses thereof

1. A compound of formula (I):

or a pharmaceutically acceptable salt thereof;

wherein:

each occurrence of R 1a is independently hydrogen, C 1-4 alkyl, or C 1-4 fluoroalkyl;

each occurrence of R 1 is independently hydrogen, chloro, fluoro, —O—C 1-4 alkyl, cyano, hydroxy, C 1-4 alkyl, or C 1-4 fluoroalkyl;

one of R 2a or R 2b is G and the other is R 1 ;

G is —R 3 , —V 1 —R 3 , —V 1 -L 1 -R 3 , -L 1 -V 1 —R 3 , or -L 1 -R 3 ;

L 1 is an unsubstituted or substituted C 1-3 alkylene chain;

V 1 is —C(O)—, —C(S)—, —C(O)—CR A ═CR A —, —C(O)—N(R 4a )—, —C(O)—O—, —S(O) 2 —, —N(R 4a )—, —N(R 4a )—C(O)—, —SO 2 —N(R 4a )—, —N(R 4a )—SO 2 —, —O—, —S—, —S(O)—, —N(R 4a )—C(O)—N(R 4a )—, —N(R 4a )—C(O)—O—, —O—C(O)—N(R 4a )—, or —N(R 4a )—SO 2 —N(R 4a )—;

R 3 is unsubstituted or substituted C 1-6 aliphatic;

unsubstituted or substituted 3-10-membered cycloaliphatic;

unsubstituted or substituted 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;

unsubstituted or substituted 6-10-membered aryl; or

unsubstituted or substituted 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur;

each occurrence of R A is independently hydrogen, fluoro, or unsubstituted or substituted C 1-4 aliphatic; and

each occurrence of R 4a is independently hydrogen, or unsubstituted or substituted C 1-4 aliphatic.

2. The compound of claim 1 , wherein:

R 2a is G; and

R 2b is R 1 .

3. The compound of claim 1 , wherein:

R 2b is G; and

R 2a is R 1 .

4. The compound of claim 1 , wherein:

G is —V 1 —R 3 , L 1 -R 3 , or —R 3 ; and

V 1 is —N(R 4a )—, —N(R 4a )—C(O)—, —N(R 4a )—SO 2 —, —O—, —N(R 4a )—C(O)—O—, or —N(R 4a )—C(O)—N(R 4a )—.

5. The compound of claim 1 , wherein:

R 1a is hydrogen; and

each occurrence of R 1 is independently hydrogen, chloro, fluoro, cyano, hydroxy, methoxy, ethoxy, isopropoxy, trifluoromethoxy, trifluoromethyl, methyl, ethyl, isopropyl, n-propyl, or tert-butyl.

6. The compound of claim 1 , wherein:

each substitutable carbon chain atom in R 3 is unsubstituted or substituted with 1-2 occurrences of —R 5dd ;

each substitutable saturated ring carbon atom in R 3 is unsubstituted or substituted with ═O, ═S, ═C(R 5 ) 2 , ═N—R 5 , or —R 5a ;

each substitutable unsaturated ring carbon atom in R 3 is unsubstituted or is substituted with —R 5a ;

each substitutable ring nitrogen atom in R 3 is unsubstituted or substituted with —R 9b ;

each R 5a is independently halogen, —NO 2 , —CN, —C(R 5 )═C(R 5 ) 2 , —C≡C—R 5 , OR 5 , —SR 6 , —S(O)R 6 , —SO 2 R 6 , —SO 2 N(R 4 ) 2 , —N(R 4 ) 2 , —NR 4 C(O)R 5 , —NR 4 C(O)N(R 4 ) 2 , —NR 4 CO 2 R 6 , —OC(O)N(R 4 ) 2 , —C(O)R 5 , —C(O)N(R 4 ) 2 , —C(═NR 4 )—N(R 4 ) 2 , —C(═NR 4 )—OR 5 , —N(R 4 )C(═NR 4 )—N(R 4 ) 2 , —N(R 4 )SO 2 R 6 , —N(R 4 )SO 2 N(R 4 ) 2 , unsubstituted or substituted C 1-6 aliphatic, unsubstituted or substituted 3-10-membered cycloaliphatic, unsubstituted or substituted 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, unsubstituted or substituted 6-10-membered aryl, or unsubstituted or substituted 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or two adjacent R 5a , taken together with the intervening ring atoms, form an unsubstituted or substituted fused aromatic ring or an unsubstituted or substituted non-aromatic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;

each occurrence of R 5dd is independently fluoro, hydroxy, —O(C 1-6 alkyl), cyano, —N(R 4 ) 2 , —C(O)(C 1-6 alkyl), —CO 2 H, —C(O)NH 2 , —NHC(O)—(C 1-6 alkyl), —NHC(O)—O—(C 1-6 alkyl), or —C(O)NH(C 1-6 alkyl);

each R 4 is independently hydrogen, unsubstituted or substituted C 1-6 aliphatic, unsubstituted or substituted 3-10-membered cycloaliphatic, unsubstituted or substituted 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, unsubstituted or substituted 6-10-membered aryl, or unsubstituted or substituted 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or two R 4 on the same nitrogen atom, taken together with the nitrogen atom, form an unsubstituted or substituted 5- to 6-membered heteroaryl or an unsubstituted or substituted 4- to 8-membered heterocyclyl having, in addition to the nitrogen atom, 0-2 ring heteroatoms selected from nitrogen, oxygen, and sulfur;

each R 5 is independently hydrogen, unsubstituted or substituted C 1-6 aliphatic, unsubstituted or substituted 3-10-membered cycloaliphatic, unsubstituted or substituted 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, unsubstituted or substituted 6-10-membered aryl, or unsubstituted or substituted 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur;

each R 6 is independently unsubstituted or substituted C 1-6 aliphatic, or unsubstituted or substituted 6-10-membered aryl;

each R 9b is independently —C(O)R 5 , —C(O)N(R 4 ) 2 , —CO 2 R 6 , —SO 2 R 6 , —SO 2 N(R 4 ) 2 , unsubstituted C 1-6 aliphatic, or C 1-6 aliphatic substituted with 1-2 occurrences of R 7 or R 8 ;

each R 7 is independently unsubstituted or substituted 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, unsubstituted or substituted 6-10-membered aryl, or unsubstituted or substituted 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur; and

each R 8 is independently halogen, —OH, —O(C 1-6 alkyl), —CN, —N(R 4 ) 2 , —C(O)(C 1-6 alkyl), —CO 2 H, —CO 2 (C 1-6 alkyl), —C(O)NH 2 , or —C(O)NH(C 1-6 alkyl).

7. The compound of claim 6 , wherein:

each substitutable saturated ring carbon atom in R 3 is unsubstituted or substituted with —R 5a ;

the total number of R 5a substituents is p;

p is 1-2;

each R 5a is independently halogen, cyano, hydroxy, unsubstituted C 1-6 aliphatic, C 1-6 aliphatic substituted with 1-2 independent occurrences of R 7 or R 8 , C 1-6 fluoroalkyl, —O—C 1-6 alkyl, —O—C 1-6 fluoroalkyl, —NHC(O)C 1-6 alkyl, —NHC(O)C 3-6 cycloalkyl, —C(O)NHC 1-6 alkyl, —NHC(O)NHC 1-6 alkyl, —NHS(O) 2 C 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-6 alkyl) 2 , 3-10-membered cycloaliphatic substituted with 0-2 occurrences of —R 7a , 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur substituted with 0-2 occurrences of —R 7a , 6-10-membered aryl substituted with 0-2 occurrences of —R 7a , or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur substituted with 0-2 occurrences of —R 7a , and

each occurrence of R 7a is independently halogen, C 1-6 aliphatic, C 1-6 fluoroalkyl, —O—C 1-6 alkyl, —O—C 1-6 fluoroalkyl, cyano, hydroxy, —NHC(O)C 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-6 alkyl) 2 , —C(O)NHC 1-6 alkyl, —NHC(O)NHC 1-6 alkyl, or —NHS(O) 2 C 1-6 alkyl.

8. The compound of claim 6 , represented by formula (I-a):

9. The compound of claim 8 , wherein:

R 1a is hydrogen; and

each occurrence of R 1 is independently hydrogen, fluoro, trifluoromethyl, or methyl.

10. The compound of claim 9 , wherein:

G is —V 1 —R 3 , -L 1 -R 3 , or —R 3 ; and

V 1 is —N(R 4a )—, —N(R 4a )—C(O)—, —N(R 4a )—SO 2 —, —O—, —N(R 4a )—C(O)—O—, or —N(R 4a )—C(O)—N(R 4a ).

11. The compound of claim 9 , wherein R 1 is hydrogen.

12. The compound of claim 9 , wherein:

each substitutable saturated ring carbon atom in R 3 is unsubstituted or substituted with —R 5a ;

the total number of R 5a substituents is p;

p is 1-2;

each R 5a is independently halogen, cyano, hydroxy, unsubstituted C 1-6 aliphatic, C 1-6 aliphatic substituted with 1-2 independent occurrences of R 7 or R 8 , C 1-6 fluoroalkyl, alkyl, —O—C 1-6 fluoroalkyl, —NHC(O)C 1-6 alkyl, —NHC(O)C 3-6 cycloalkyl, —C(O)NHC 1-6 alkyl, —NHC(O)NHC 1-6 alkyl, —NHS(O) 2 C 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-6 alkyl) 2 , 3-10-membered cycloaliphatic substituted with 0-2 occurrences of —R 7a , 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur substituted with 0-2 occurrences of —R 7a , 6-10-membered aryl substituted with 0-2 occurrences of —R 7a , or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur substituted with 0-2 occurrences of —R 7a , and

each occurrence of R 7a is independently halogen, C 1-6 aliphatic, C 1-6 fluoroalkyl, —O—C 1-6 alkyl, —O—C 1-6 fluoroalkyl, cyano, hydroxy, —NHC(O)C 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-6 alkyl) 2 , —C(O)NHC 1-6 alkyl, —NHC(O)NHC 1-6 alkyl, or —NHS(O) 2 C 1-6 alkyl.

13. The compound of claim 6 , represented by formula (I-b):

14. The compound of claim 13 , wherein:

R 1a is hydrogen; and

each occurrence of R 1 is independently hydrogen, fluoro, trifluoromethyl, or methyl.

15. The compound of claim 14 , wherein:

G is —V 1 —R 3 , -L 1 -R 3 , or —R 3 ; and

V 1 is —N(R 4a )—, —N(R 4a )—C(O)—, —N(R 4a )—SO 2 —, —O—, —N(R 4a )—C(O)—O—, or —N(R 4a )—C(O)—N(R 4a )—.

16. The compound of claim 14 , wherein R 1 is hydrogen.

17. The compound of claim 14 , wherein:

each substitutable saturated ring carbon atom in R 3 is unsubstituted or substituted with —R 5a ;

the total number of R 5a substituents is p;

p is 1-2;

each R 5a is independently halogen, cyano, hydroxy, unsubstituted C 1-6 aliphatic, C 1-6 aliphatic substituted with 1-2 independent occurrences of R 7 or R 8 , C 1-6 fluoroalkyl, alkyl, —O—C 1-6 fluoroalkyl, —NHC(O)C 1-6 alkyl, —NHC(O)C 3-6 cycloalkyl, —C(O)NHC 1-6 alkyl, —NHC(O)NHC 1-6 alkyl, —NHS(O) 2 C 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-6 alkyl) 2 , 3-10-membered cycloaliphatic substituted with 0-2 occurrences of —R 7a , 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur substituted with 0-2 occurrences of —R 7a , 6-10-membered aryl substituted with 0-2 occurrences of or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur substituted with 0-2 occurrences of —R 7a , and

each occurrence of R 7a is independently halogen, C 1-6 aliphatic, C 1-6 fluoroalkyl, —O—C 1-6 alkyl, —O—C 1-6 fluoroalkyl, cyano, hydroxy, —NHC(O)C 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-6 alkyl) 2 , —C(O)NHC 1-6 alkyl, —NHC(O)NHC 1-6 alkyl, or —NHS(O) 2 C 1-6 alkyl.

18. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.

19. The compound of claim 1 , wherein the compound is:

I-1

6-{[3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoyl]amino}-

N-hydroxyquinoline-3-carboxamide,

I-2

6-(3-chlorophenoxy)-N-hydroxyquinoline-3-carboxamide,

I-3

N-hydroxy-7-methoxyquinoline-3-carboxamide,

I-4

N-hydroxy-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-

quinoline-3-carboxamide,

I-5

N-hydroxy-7-[(4-methoxybenzoyl)amino]quinoline-3-carboxamide,

I-6

6-[(cyclopropylcarbonyl)amino]-N-hydroxyquinoline-3-

carboxamide,

I-7

6-anilino-N-hydroxyquinoline-3-carboxamide,

I-8

N-hydroxy-6-{[3-(1-methyl-1H-pyrazol-4-yl)-5-

(trifluoromethyl)benzoyl]amino}quinoline-3-carboxamide,

I-9

N-hydroxy-6-(pyridin-4-ylamino)quinoline-3-carboxamide,

I-10

tert-butyl {3-[(hydroxyamino)carbonyl]quinolin-7-yl}carbamate,

I-11

N-hydroxy-6-pyridin-4-ylquinoline-3-carboxamide,

I-12

N-hydroxy-6-phenoxyquinoline-3-carboxamide,

I-13

N-hydroxy-6-[(phenylsulfonyl)amino]quinoline-3-carboxamide,

I-14

6-[(anilinocarbonyl)amino]-N-hydroxyquinoline-3-carboxamide,

I-15

7-(3-chlorophenoxy)-N-hydroxyquinoline-3-carboxamide,

I-16

7-(4-chlorophenoxy)-N-hydroxyquinoline-3-carboxamide,

I-17

6-(benzylamino)-N-hydroxyquinoline-3-carboxamide,

I-18

N-hydroxy-6-(2-phenylethyl)quinoline-3-carboxamide,

I-19

N-hydroxy-6-methoxyquinoline-3-carboxamide,

I-20

6-(benzoylamino)-N-hydroxyquinoline-3-carboxamide,

I-21

tert-butyl {3-[(hydroxyamino)carbonyl]quinolin-6-yl}carbamate,

I-22

N-hydroxy-6-[(4-methoxybenzoyl)amino]quinoline-3-carboxamide,

I-23

7-({2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}oxy)-N-

hydroxyquinoline-3-carboxamide,

I-24

7-anilino-N-hydroxyquinoline-3-carboxamide,

I-25

7-(4-chlorophenyl)-N-hydroxyquinoline-3-carboxamide,

I-26

N-hydroxy-6-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)-

oxy]quinoline-3-carboxamide,

I-27

6-(4-chlorophenyl)-N-hydroxyquinoline-3-carboxamide, or

I-28

N-hydroxy-7-(pyridin-4-ylamino)quinoline-3-carboxamide.

20. The compound of claim 1 , wherein the compound is:

I-29

6-(4-chlorophenoxy)-N-hydroxyquinoline-3-carboxamide,

I-30

6-[(4-chlorophenyl)amino]-N-hydroxyquinoline-3-carboxamide,

I-31

6-({2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}oxy)-N-

hydroxyquinoline-3-carboxamide,

I-32

N-hydroxy-6-(pyridin-4-yloxy)quinoline-3-carboxamide,

I-33

N-hydroxy-7-pyridin-4-ylquinoline-3-carboxamide,

I-34

N-hydroxy-6-{[(4-methylpiperidin-4-yl)carbonyl]amino}-

quinoline-3-carboxamide,

I-35

6-[2-(dimethylamino)ethoxy]-N-hydroxyquinoline-3-carboxamide,

I-36

N-hydroxy-6-{[(1-methylcyclohexyl)carbonyl]amino}quinoline-3-

carboxamide,

I-37

6-[(2-adamantylcarbonyl)amino]-N-hydroxyquinoline-3-

carboxamide,

I-38

6-{3-[2-(dimethylamino)ethoxy]phenyl}-N-hydroxyquinoline-3-

carboxamide,

I-39

N-hydroxy-6-(2-morpholin-4-ylethoxy)quinoline-3-carboxamide,

I-40

N-hydroxy-6-(2-pyridin-2-ylethyl)quinoline-3-carboxamide,

I-41

N-hydroxy-6-(3-pyrrolidin-1-ylpropyl)quinoline-3-carboxamide,

I-42

N-hydroxy-6-[2-(3-thienyl)ethyl]quinoline-3-carboxamide,

I-43

6-(4-chlorophenyl)-N-hydroxy-8-methylquinoline-3-carboxamide,

I-44

6-({2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}oxy)-N-hydroxy-8-

methylquinoline-3-carboxamide,

I-45

N-hydroxy-8-methyl-6-(pyridin-4-ylamino)quinoline-3-carboxamide,

I-46

N-hydroxy-2,8-dimethyl-6-(2-phenylethyl)quinoline-3-carboxamide,

I-47

6-(4-chlorophenoxy)-N-hydroxy-2,8-dimethylquinoline-3-

carboxamide,

I-48

N-hydroxy-2,8-dimethyl-6-{[3-(1-methyl-1H-pyrazol-4-yl)-5-

(trifluoromethyl)benzoyl]amino}quinoline-3-carboxamide,

I-49

N-hydroxy-2-methyl-6-{[(4-methylpiperidin-4-yl)carbonyl]amino}-

quinoline-3-carboxamide,

I-50

N-hydroxy-2-methyl-6-pyridin-4-ylquinoline-3-carboxamide,

I-51

N-hydroxy-2-methyl-6-[(7-oxo-5,6,7,8-tetrahydro-1,8-

naphthyridin-4-yl)oxy]quinoline-3-carboxamide,

I-52

6-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-N-hydroxy-4-

methylquinoline-3-carboxamide,

I-53

6-{[3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoyl]amino}-

N-hydroxy-4-methylquinoline-3-carboxamide,

I-54

6-(3-chlorophenoxy)-N-hydroxy-4-methylquinoline-3-carboxamide,

I-55

6-({[(3-chlorophenyl)amino]carbonyl}amino)-N-hydroxy-8-

methyl-4-(trifluoromethyl)quinoline-3-carboxamide, or

I-56

N-hydroxy-8-methyl-6-(2-phenylethyl)-4-(trifluoromethyl)-

quinoline-3-carboxamide.

21. The compound of claim 1 , wherein the compound is:

I-57

N-hydroxy-8-methyl-6-{[(4-methylphenyl)sulfonyl]amino}-4-

(trifluoromethyl)quinoline-3-carboxamide,

I-58

6-[(2-adamantylcarbonyl)amino]-N-hydroxy-8-methyl-4-

(trifluoromethyl)quinoline-3-carboxamide,

I-59

N-hydroxy-6-(pyridin-4-yloxy)-4-(trifluoromethyl)quinoline-3-

carboxamide,

I-60

6-({2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}oxy)-N-hydroxy-4-

(trifluoromethyl)quinoline-3-carboxamide,

I-61

N-hydroxy-6-(3-pyrrolidin-1-ylpropyl)-4-(trifluoromethyl)-

quinoline-3-carboxamide,

I-62

6-{6-[(cyclopropylcarbonyl)amino]pyrimidin-4-yl}-N-hydroxy-4-

(trifluoromethyl)quinoline-3-carboxamide,

I-63

6-{3-[2-(dimethylamino)ethoxy]phenyl}-N-hydroxy-4-

(trifluoromethyl)quinoline-3-carboxamide,

I-64

5-chloro-N-hydroxy-8-methoxy-6-pyridin-4-yl-4-(trifluoromethyl)-

quinoline-3-carboxamide,

I-65

5-chloro-N-hydroxy-8-methoxy-6-[(3-methoxybenzoyl)amino]-4-

(trifluoromethyl)quinoline-3-carboxamide,

I-66

5-chloro-N-hydroxy-8-methoxy-6-{[(4-methylpiperidin-4-yl)-

carbonyl]amino}-4-(trifluoromethyl)quinoline-3-carboxamide,

I-67

5-chloro-N-hydroxy-8-methoxy-6-[(phenylsulfonyl)amino]-4-

(trifluoromethyl)quinoline-3-carboxamide,

I-68

N-hydroxy-8-methoxy-6-(2-phenylethyl)-4-(trifluoromethyl)-

quinoline-3-carboxamide,

I-69

N-hydroxy-6-(1H-indol-2-yl)-8-methoxy-4-(trifluoromethyl)-

quinoline-3-carboxamide,

I-70

N-hydroxy-8-methoxy-6-{[(1-methylcyclohexyl)carbonyl]amino}-4-

(trifluoromethyl)quinoline-3-carboxamide,

I-71

6-{3-[(2,2-dimethylpropanoyl)amino]phenyl}-N-hydroxy-8-

methoxy-4-(trifluoromethyl)quinoline-3-carboxamide,

I-72

N-hydroxy-2-methyl-7-(2-pyridin-2-ylethyl)quinoline-3-

carboxamide,

1-73

N-hydroxy-6,7-dimethoxy-4-(trifluoromethyl)quinoline-3-

carboxamide,

I-74

N-hydroxy-6,7-dimethoxyquinoline-3-carboxamide,

I-75

7-({2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}oxy)-N-hydroxy-6-

methoxyquinoline-3-carboxamide,

I-76

N-hydroxy-6-methoxy-7-(pyridin-4-yloxy)quinoline-3-carboxamide,

I-77

7-(4-chlorophenoxy)-N-hydroxy-6-methoxyquinoline-3-

carboxamide,

I-78

N-hydroxy-7-{[(1-methylcyclohexyl)carbonyl]amino}quinoline-3-

carboxamide,

I-79

N-hydroxy-2-methyl-7-pyridin-4-ylquinoline-3-carboxamide,

I-80

N-hydroxy-8-methyl-7-(2-phenylethyl)quinoline-3-carboxamide,

I-81

N-hydroxy-7-[(4-methoxybenzoyl)amino]-8-

methylquinoline-3-carboxamide,

I-82

N-hydroxy-8-methyl-7-[(phenylsulfonyl)amino]quinoline-3-

carboxamide,

I-83

benzyl{3-[(hydroxyamino)carbonyl]-8-methylquinolin-7-yl}-

carbamate, or

I-84

7-{3-[(2,2-dimethylpropanoyl)amino]phenyl}-N-hydroxy-2-

methylquinoline-3-carboxamide.

22. The compound of claim 1 , wherein the compound is:

I-85

N-hydroxy-8-methyl-7-(2-pyridin-3-ylethyl)quinoline-3-

carboxamide,

I-86

N-hydroxy-8-methyl-7-({[(4-methylphenyl)amino]carbonyl}amino)-

quinoline-3-carboxamide,

I-87

N-hydroxy-8-methyl-7-(pyridin-4-ylamino)quinoline-3-carboxamide,

I-88

N-hydroxy-7-[(3-methoxyphenyl)amino]-8-methylquinoline-3-

carboxamide,

I-89

N-hydroxy-7-(2-methoxyphenyl)-2-methylquinoline-3-carboxamide,

I-90

7-[(3-chlorophenyl)amino]-N-hydroxy-8-methylquinoline-3-

carboxamide,

I-91

N-hydroxy-2-methyl-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-

naphthyridin-4-yl)oxy]quinoline-3-carboxamide,

I-92

7-({2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}oxy)-N-hydroxy-2-

methylquinoline-3-carboxamide,

I-93

N-hydroxy-2-methyl-7-(3-{[(1-methylcyclohexyl)carbonyl]-

amino}phenoxy)quinoline-3-carboxamide,

I-94

7-[(2,2-dimethylpropanoyl)amino]-N-hydroxy-2-methylquinoline-3-

carboxamide,

I-95

N-hydroxy-7-[(4-methoxyphenyl)amino]-2-methylquinoline-3-

carboxamide,

I-96

N-hydroxy-7-{[(4-methylpiperidin-4-yl)carbonyl]amino}quinoline-3-

carboxamide,

I-97

N-hydroxy-7-[2-(3-piperazin-1-ylphenyl)ethyl]quinoline-3-

carboxamide,

I-98

N-hydroxy-7-[2-(1-isopropylpiperidin-4-yl)pyridin-4-yl]quinoline-3-

carboxamide,

I-99

N-hydroxy-7-{2-[3-(1-methylpiperidin-4-yl)phenyl]ethyl}-

quinoline-3-carboxamide,

I-100

N-hydroxy-7-(3-piperidin-4-ylphenyl)quinoline-3-carboxamide,

I-101

N3-hydroxy-N7-(2-{[(4-methylpiperidin-4-yl)carbonyl]amino}-

pyridin-4-yl)quinoline-3,7-dicarboxamide,

I-102

N3-hydroxy-N7-piperidin-4-ylquinoline-3,7-dicarboxamide,

I-103

N-hydroxy-7-(2-piperidin-4-ylpyridin-4-yl)quinoline-3-carboxamide,

I-104

N-hydroxy-7-{2-[(piperidin-4-ylcarbonyl)amino]pyridin-4-yl}-

quinoline-3-carboxamide,

I-105

N-hydroxy-6-piperidin-4-ylquinoline-3-carboxamide,

I-106

N-hydroxy-7-(2-{[(4-methylpiperidin-4-yl)carbonyl]amino}-

pyridin-4-yl)quinoline-3-carboxamide,

I-107

N-hydroxy-7-{3-[(pyrrolidin-3-ylcarbonyl)amino]benzyl}-

quinoline-3-carboxamide,

I-108

N-hydroxy-6-(2-piperidin-4-ylpyridin-4-yl)quinoline-3-carboxamide,

I-109

7-(2-{[(1-ethyl-4-methylpiperidin-4-yl)carbonyl]amino}pyridin-4-

yl)-N-hydroxyquinoline-3-carboxamide,

I-110

N-hydroxy-7-(2-piperidin-4-ylethyl)quinoline-3-carboxamide,

I-111

N-hydroxy-7-[(2-{[(1-isopropylpiperidin-4-yl)carbonyl]amino}-

pyridin-4-yl)oxy]quinoline-3-carboxamide, or

I-112

N-hydroxy-6-{2-[(piperidin-4-ylcarbonyl)amino]pyridin-4-yl}-

quinoline-3-carboxamide.