IP Library Granted Patent US 8,518,316
Granted Patent B2
US 8,518,316 · App. 13/156,147 · Granted Aug 27, 2013

System and method for producing particles and patterned films

Inventors: Robert Lyon Henn (Raleigh, NC); Alex Ermoshkin (Chapel Hill, NC); Kyle Matthew Benjamin Henn (Raleigh, NC); Benjamin Maynor (Durham, NC); Jason Rolland (Belmont, MA); Robert Praino (Westwood, MA)
Assignee: Liquidia Technologies, Inc.
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,518,316
App. No.
13/156,147
Granted
Aug 27, 2013
Kind
B2
Abstract

A system including a mold having a fluoropolymer wherein the mold defines a plurality of cavities having a predetermined shape and a cross-sectional dimension less than about 100 micrometers; a roller; a surface in cooperation with the roller to form a nip point configured to receive the mold, wherein the nip point is further configured to receive a substantially liquid composition and accelerate entry of the substantially liquid composition into the cavity. A method of forming particles including applying a substantially liquid composition to a mold, wherein the mold comprises a fluoropolymer and defines a plurality of cavities each having a broadest cross-sectional dimension of less than about 100 micrometers; nipping the mold between a roller and a surface such that the substantially liquid composition enters the cavities of the mold; and hardening the substantially liquid composition in the cavities of the mold to form a particle within each cavity, wherein the particle has a size and shape that substantially mimics the size and shape of the cavity of the mold.

Claims (20)

1. A method for harvesting particles comprising:

(a) passing a base substrate and an array of micro- or nano-particles coupled therewith through a nip point, wherein the base substrate is coupled with a single surface of each particle in the array of micro- or nano-particles;

(b) applying a solvent to the nip point, wherein the solvent disengages the micro- or nano-particles from the base substrate and releases the micro- or nano-particles into a solution substantially contained near the nip point; and

(c) collecting the solution containing the released micro- or nano-particles.

2. The method of claim 1 , wherein the base substrate includes a surface treated with a soluble substance.

3. The method of claim 2 , wherein the solvent dissolves the soluble substance to release the micro- or nano-particles into the solution.

4. The method of claim 1 , wherein the solvent is contained within the nip point using air jets.

5. The method of claim 1 , wherein the micro- or nano-particles include a plurality of substantially uniform shape and size particles having a broadest cross-sectional dimension of less than about 100 micrometers.

6. The method of claim 1 , wherein the micro- or nano-particles include a plurality of substantially uniform shape and size particles having a broadest cross-sectional dimension of less than about 10 micrometers.

7. The method of claim 1 , wherein the micro- or nano-particles include a plurality of substantially uniform shape and size particles having a broadest cross-sectional dimension of less than about 1 micrometer.

8. The method of claim 1 , wherein the micro- or nano-particles include a plurality of substantially uniform shape and size particles having a broadest cross-sectional dimension of less than about 500 nanometers.

9. A method for harvesting particles comprising:

(a) coupling a single surface of each of a plurality of micro- or nano-particles with a soluble substance on a base substrate;

(b) introducing a solvent to the base substrate having the micro- or nano-particles coupled therewith;

(c) allowing the solvent to release the micro- or nano-particles from the base substrate by disengaging the soluble substance from the base substrate; and

(d) collecting the released micro- or nano-particles.

10. The method of claim 9 , wherein the micro- or nano-particles include a plurality of substantially uniform shape and size particles having a broadest cross-sectional dimension of less than about 100 micrometers.

11. The method of claim 9 , wherein the micro- or nano-particles include a plurality of substantially uniform shape and size particles having a broadest cross-sectional dimension of less than about 10 micrometers.

12. The method of claim 9 , wherein the micro- or nano-particles include a plurality of substantially uniform shape and size particles having a broadest cross-sectional dimension of less than about 1 micrometer.

13. The method of claim 9 , wherein the micro- or nano-particles include a plurality of substantially uniform shape and size particles having a broadest cross-sectional dimension of less than about 500 nanometers.

Assignments (4)
ASSIGNMENT OF IP SECURITY AGREEMENT RECORDED AT REEL/FRAME 062643/0791 Recorded May 11, 2023
From: HCR COLLATERAL MANAGEMENT, LLC, AS RETIRING SUBORDINATED LENDER
To: HEALTHCARE ROYALTY PARTNERS IV, L.P., AS SUCCESSOR SUBORDINATED LENDER
Reel/Frame 063627/0307 →
SECURITY INTEREST Recorded Feb 9, 2023
From: LIQUIDIA TECHNOLOGIES, INC.
To: HCR COLLATERAL MANAGEMENT, LLC
Reel/Frame 062643/0791 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 10, 2013
From: ROLLAND, JASON; PRAINO, ROBERT
To: LIQUIDIA TECHNOLOGIES, INC.
Reel/Frame 030397/0226 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 9, 2013
From: HENN, ROBERT; ERMOSHKIN, ALEX; HENN, KYLE; MAYNOR, BENJAMIN
To: LIQUIDIA TECHNOLOGIES, INC.
Reel/Frame 030391/0090 →
Continuity (3)
Continuation 12250461 · Oct 13, 2008
Provisional Application 60979710 · Oct 12, 2007
Related Publication 20110300293A1 · Dec 8, 2011