IP Library Granted Patent US 8,545,693
Granted Patent B2
US 8,545,693 · App. 12/875,887 · Granted Oct 1, 2013

Analyte measurment method and system

Inventors: David McColl (Inverness, GB); Adam Craggs (Inverness, GB); Stephen MacKintosh (Inverness, GB); Steve Blythe (Inverness, GB); Marco Cardosi (Croy, GB)
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Quick Facts
Patent No.
US 8,545,693
App. No.
12/875,887
Granted
Oct 1, 2013
Kind
B2
Abstract

Described and illustrated herein are systems and exemplary methods of operating a multianalyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a test voltage between a reference electrode and a first working electrode; measuring a first test current, a second test current and a third test current at the working electrode with the meter after a blood sample containing an analyte is applied to the test strip; estimating a hematocrit-corrected analyte concentration from the first, second and third test currents; and displaying the hematocrit-corrected analyte concentration.

Claims (72)

1. A method for determining a glucose concentration measurable with a system having a test strip and a meter, the method comprising:

applying a test voltage between a reference electrode and a working electrode coated with a reagent layer disposed on a matrix layer having a mediator;

measuring a first test current, a second test current and a third test current at the working electrode with the meter after a blood sample containing an analyte is applied to the test strip to physically transform the analyte into an enzymatic by-product;

determining a glucose concentration from the first, second and third test currents, in which the glucose concentration comprises a value obtained with the following:

G

=

[

(

I

1

I

2

)

p

I

3

]

-

intercept

1

slope

1

where:

G comprises the glucose concentration;

I 1 comprises the first test current;

I 2 comprises the second test current;

I 3 comprises the third test current;

p comprises a power term that depends on of the third test current in which the power term p comprises a value obtained with the following:

p

=

a

-

b

I

3

 where a comprises a first tuning parameter between 2.5 and 5 and b comprises a second tuning parameter between 1.75 and 5;

intercept 1 comprises an intercept value determined from a linear regression of a plot of

[

(

I

1

I

2

)

p

I

3

]

 versus a reference glucose concentration for a batch of test strips; and

slope 1 comprises a slope value determined from a linear regression of a plot of

[

(

I

1

I

2

)

p

I

3

]

 versus the reference glucose concentration for the particular batch of test strip; and

displaying the glucose concentration.

2. The method of claim 1 , in which the threshold value of the first test current comprises from about 5 microamperes to about 7 microamperes.

3. The method of claim 1 , in which the power term comprises a value from about one to about four.

Assignments (16)
SECURITY INTEREST Recorded Dec 8, 2025
From: LIFESCAN ENTERPRISES LLC
To: ACQUIOM AGENCY SERVICES LLC, AS COLLATERAL AGENT
Reel/Frame 073890/0305 →
RELEASE OF SECURITY INTEREST Recorded Dec 8, 2025
From: WILMINGTON SAVINGS FUND SOCIETY, FSB
To: LIFESCAN IP HOLDINGS, LLC
Reel/Frame 073929/0316 →
RELEASE OF SECURITY INTEREST Recorded Dec 8, 2025
From: WILMINGTON SAVINGS FUND SOCIETY, FSBWILMINGTON SAVINGS FUND SOCIETY, FSB
To: LIFESCAN IP HOLDINGS, LLC
Reel/Frame 073928/0626 →
SECURITY AGREEMENT Recorded Dec 8, 2025
From: LIFESCAN ENTERPRISES LLC
To: WELLS FARGO BANK, NATIONAL ASSOCIATION
Reel/Frame 073893/0622 →
RELEASE OF SECURITY INTEREST Recorded Dec 8, 2025
From: ANKURA TRUST COMPANY, LLC
To: LIFESCAN IP HOLDINGS, LLC
Reel/Frame 073929/0495 →
ASSIGNMENT OF PATENT SECURITY INTERESTS (1ST LIEN) Recorded Aug 22, 2025
From: BANK OF AMERICA, N.A.
To: WILMINGTON SAVINGS FUND SOCIETY, FSB, AS SUCCESSOR AGENT
Reel/Frame 072567/0482 →
SECOND LIEN PATENT SECURITY AGREEMENT Recorded Jan 13, 2025
From: LIFESCAN IP HOLDINGS, LLC
To: WILMINGTON SAVING FUND SOCIETY, FSB, AS COLLATERAL AGENT
Reel/Frame 069880/0983 →
SECURITY AGREEMENT (FIRST LIEN SUPPLEMENTAL) Recorded Jan 10, 2025
From: LIFESCAN IP HOLDINGS, LLC
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 069868/0599 →
TRANSFER OF SECURITY AGREEMENT RECORDED AT REEL 047179, FRAME 0150 Recorded Nov 11, 2024
From: BANK OF AMERICA, N.A., AS RESIGNING AGENT
To: ANKURA TRUST COMPANY, LLC, AS SUCCESSOR AGENT
Reel/Frame 069314/0022 →
RELEASE OF SECOND LIEN PATENT SECURITY AGREEMENT RECORDED OCT. 3, 2018, REEL/FRAME 047186/0836 Recorded Jun 28, 2023
From: BANK OF AMERICA, N.A.
To: LIFESCAN IP HOLDINGS, LLC; JANSSEN BIOTECH, INC.; JOHNSON & JOHNSON CONSUMER INC.
Reel/Frame 064206/0176 →
CORRECTIVE ASSIGNMENT TO CORRECT THE DELETING PROPERTY NUMBER 6990849, 7169116, 7351770, 7462265,7468125, 7572356, 8093903, 8486245, 8066866 AND ADD 10431140 PREVIOUSLY RECORDED AT REEL: 050839 FRAME: 0634. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded May 12, 2023
From: LIFESCAN SCOTLAND LTD.
To: CILAG GMBH INTERNATIONAL
Reel/Frame 064656/0141 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2019
From: CILAG GMBH INTERNATIONAL
To: LIFESCAN IP HOLDINGS, LLC
Reel/Frame 050840/0006 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2019
From: LIFESCAN SCOTLAND LTD.
To: CILAG GMBH INTERNATIONAL
Reel/Frame 050839/0634 →
SECURITY AGREEMENT Recorded Oct 3, 2018
From: LIFESCAN IP HOLDINGS, LLC
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 047186/0836 →
SECURITY AGREEMENT Recorded Oct 2, 2018
From: LIFESCAN IP HOLDINGS, LLC
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 047179/0150 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 3, 2010
From: MCCOLL, DAVID; CRAGGS, ADAM; MACKINTOSH, STEPHEN; BLYTHE, STEVE; CARDOSI, MARCO
To: LIFESCAN SCOTLAND, LTD.
Reel/Frame 024940/0077 →
Continuity (3)
Provisional Application 61246858 · Sep 29, 2009
Provisional Application 61286106 · Dec 14, 2009
Related Publication 20110073494A1 · Mar 31, 2011