Pharmaceutical preparations for oral administration, containing ion-exchange resins loaded with active ingredients and intrinsically viscous gelling agents as thickening agents
The present invention relates to pharmaceutical preparations for oral administration, comprising one or more active substances bound to an ion exchanger. In order to improve physical stability and acceptance, particularly in animals, a pseudoplastic gel-former thickener is included.
1. A liquid pharmaceutical preparation comprising pradofloxacin bound to an ion exchange resin dispersed in a carrier medium comprising water and xanthan as a pseudoplastic gel former, wherein the concentration of xanthan in the preparation is from 0.3% to 0.7% by weight.
2. The pharmaceutical preparation according to claim 1 , wherein the ion exchange resin is an acidic ion exchanger.
3. The pharmaceutical preparation according to claim 1 , wherein the loading of ion exchange resin with pradofloxacin in the preparation is from 1% to 50% by weight, based on the total weight of the preparation.
4. The pharmaceutical preparation according to claim 1 , wherein the loading of ion exchange resin with pradofloxacin in the preparation is from 5% to 30% by weight, based on the total weight of the preparation.
5. The pharmaceutical preparation according to claim 1 , wherein the carrier medium is from 10 to 98% by weight of the total preparation.
6. The pharmaceutical preparation according to claim 1 , wherein the carrier medium is from 20% to 90% by weight of the total preparation.
7. The pharmaceutical preparation according to claim 1 , wherein the loading of ion exchange resin with pradofloxacin in the preparation is from 5% to 25% by weight, based on the total weight of the preparation.
8. The pharmaceutical preparation according to claim 1 , further comprising bentonite.
9. The pharmaceutical preparation according to claim 1 , wherein the concentration of xanthan in the preparation is from 0.5% to 0.7% by weight.
10. The pharmaceutical preparation according to claim 1 , wherein the concentration of xanthan in the preparation is about 0.7% by weight.