Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
1. An isolated monoclonal antibody, wherein, when bound to PCSK9, said monoclonal antibody binds to at least one residue within the sequence set forth by residues 123-132 of SEQ ID NO: 1, and wherein said monoclonal antibody reduces binding between PCSK9 and an EGFa domain of LDLR protein antagonizes PCSK9's inhibition of cellular LDL uptake.
2. The isolated monoclonal antibody of claim 1 , wherein the monoclonal antibody comprises a humanized or human antibody.
3. The isolated monoclonal antibody of claim 1 , wherein the monoclonal antibody comprises a full length monoclonal antibody.
4. The isolated monoclonal antibody of claim 3 , wherein said monoclonal antibody is of the IgG4- or the IgG2-type.
5. A pharmaceutical composition comprising the monoclonal antibody of claim 1 .
6. The isolated monoclonal antibody of claim 1 , wherein the monoclonal antibody is an immunologically functional fragment.