High concentration antibody-containing liquid formulation
The problem to be solved is to provide an antibody-containing formulation which is stable and suited for subcutaneous administration, wherein dimerization and deamidation is prevented during long-term storage. The present application is directed to a stable antibody-containing liquid formulation characterized by containing arginine and methionine.
1. A stable liquid formulation suitable for subcutaneous administration comprising 180 mg/mL humanized anti-IL-6 receptor IgG1 antibody, 100 mM arginine, 10 to 50 mM methionine, further comprising 0.005 to 3% polysorbate 80 and 20 mM histidine buffer, said formulation having a pH of 6.
2. The stable liquid formulation of claim 1 wherein the antibody comprises the humanized anti-IL-6 receptor IgG1 antibody MRA.