Measurement of patient physiological parameters
A method of determining one or more physiological parameter of a patient by providing a plurality of implantable electrodes proximate a blood vessel of the patient, applying a measurement signal through the plurality of electrodes, the measurement signal having a known parameter, obtaining a resultant signal through the plurality of electrodes, the resultant signal having a resultant parameter, calculating vascular impedance based on the measurement signal and the resultant signal, and calculating a physiological parameter based on the vascular impedance. In some embodiments, the physiological parameter is utilized to modify a therapy signal controlling therapy delivered to the patient.
1. A system, comprising:
a means for measuring a physiological parameter of a patient;
an implantable measurement device including an electrode, the measurement device configured to be implanted such that the electrode is in contact with a wall of a blood vessel of the patient; and
a control system coupled to the implantable measurement device, the control system programmed to determine an impedance of the blood vessel using the implantable measurement device, and calculate patient information based at least in part on the blood vessel impedance, wherein the control system is configured to selectively adjust the program for determining an impedance of the blood vessel based at least in part on data from the means for measuring a physiological parameter.
2. The system of claim 1 , further comprising an external programmer device communicably coupleable to the control system.
3. The system of claim 2 , wherein the control system selectively adjusts the program in response to a command received from the external programmer device.
4. The system of claim 2 , wherein the external programmer device includes a display configured to display the patient information and/or the physiological parameter.
5. The system of claim 1 , wherein the control system includes an implantable pulse generator.
6. The system of claim 1 , wherein the means for measuring a physiological parameter of the patient comprises a blood pressure sensing means.
7. The system of claim 6 , wherein the blood pressure sensing means comprises a sphygmomanometer.
8. The system of claim 6 , wherein the blood pressure sensing means comprises an implanted blood pressure sensor, and the blood pressure sensor is coupled to the control system.
9. The system of claim 6 , wherein the patient information based on the blood vessel impedance is related to heart rate.
10. The system of claim 6 , wherein the patient information based on the blood vessel impedance is related to blood pressure.
11. The system of claim 6 , further comprising a means for measuring a heart rate of the patient, and wherein the control system is further configured to receive data from the means for measuring heart rate and selectively adjust the patient information provided to the display.
12. The system of claim 1 , wherein the means for measuring a physiological parameter of the patient comprises a heart rate sensing means.
13. The system of claim 12 , wherein the heart rate sensing means comprises an implanted heart rate sensor, and the heart rate sensor is coupled to the control system.
14. The system of claim 1 , wherein the control system is further programmed to deliver a baroreflex therapy via the electrode to stimulate a baroreceptor in the blood vessel, the baroreflex therapy based at least in part on the blood vessel impedance and the data from the means for measuring a physiological parameter of the patient.
15. A method, comprising:
causing a means for measuring a physiological parameter of a patient to be manufactured and made available to a user;
causing an implantable measurement device to be manufactured and made available to the user, the implantable measurement device including an electrode;
causing a control system to be manufactured and made available to the user, the control system coupleable to the implantable measurement device; and
providing instructions to the user, the instructions comprising:
implanting the implantable measurement device within a patient such that the electrode is in contact with a wall of a blood vessel of the patient;
causing the control system to determine an impedance of the blood vessel using the implantable measurement device;
causing the control system to calculate patient information based at least in part on the blood vessel impedance; and
comparing data from the means for measuring a physiological parameter of the patient to the impedance of the blood vessel.
16. The method of claim 15 , wherein the control system includes an external programmer device communicably coupled to the control system.
17. The method of claim 16 , wherein the control system is programmed to determine an impedance of the blood vessel using the implantable measurement device, wherein the external programmer device includes a display configured to display the patient information and/or the physiological parameter, and wherein the control system is further programmed to provide patient information to the display, the instructions comprising:
causing the control system to access the program to determine an impedance of the blood vessel using the implantable measurement device; and
selectively adjusting the program for determining an impedance of the blood vessel based at least in part on data from the means for measuring a physiological parameter.
18. The method of claim 16 , wherein the control system is programmed to determine an impedance of the blood vessel using the implantable measurement device, wherein the external programmer device includes a display configured to display the patient information and/or the physiological parameter, and wherein the control system is further programmed to provide patient information to the display, the instructions comprising:
causing the control system to access the program to determine an impedance of the blood vessel using the implantable measurement device, wherein the control system selectively adjusts the program in response to a command received from the external programmer device.
19. The method of claim 15 , wherein the means for measuring a physiological parameter of the patient comprises a blood pressure sensing means.
20. The system of claim 19 , wherein the blood pressure sensing means comprises a sphygmomanometer.
21. The system of claim 19 , wherein the blood pressure sensing means comprises an implanted blood pressure sensor, and the blood pressure sensor is coupled to the control system.
22. The system of claim 19 , wherein the patient information based on the blood vessel impedance is related to heart rate.
23. The system of claim 19 , wherein the patient information based on the blood vessel impedance is related to blood pressure.
24. The system of claim 19 , further comprising a means for measuring a heart rate of the patient, and wherein the control system is further configured to receive data from the means for measuring heart rate and selectively adjust the patient information provided to the display.
25. The system of claim 15 , wherein the means for measuring a physiological parameter of the patient comprises a heart rate sensing means.
26. The system of claim 25 , wherein the heart rate sensing means comprises an implanted heart rate sensor, and the heart rate sensor is coupled to the control system.
27. The system of claim 15 , wherein the control system is further programmed to deliver a baroreflex therapy via the electrode to stimulate a baroreceptor in the blood vessel, the baroreflex therapy based at least in part on the blood vessel impedance and the data from the means for measuring a physiological parameter of the patient.
28. The method of claim 15 , wherein the instructions for implanting the implantable measurement device within a patient further comprise:
implanting the implantable measurement device within a blood vessel of a patient such that the electrode is in contact with a wall of a blood vessel of the patient.
29. The method of claim 15 , wherein the instructions for implanting the implantable measurement device within a patient further comprise:
implanting the implantable measurement device blood vessel of a patient such that the electrode is in contact with a wall of a blood vessel of the patient.
30. The method of claim 15 , wherein the instructions for implanting the implantable measurement device within a patient further comprise:
implanting the implantable measurement device at a location within a patient proximate one or more baroreceptors, the location selected from the group consisting of: a carotid sinus, an aortic arch, a common carotid artery, a subclavian artery, a brachiocephalic artery, and a heart.
31. A method of calibrating a system, the system including a means for measuring a physiological parameter of a patient, an implantable measurement device including an electrode implanted in contact with a wall of a blood vessel of the patient, and a control system coupled to the measurement device, the method comprising:
causing the control system to determine an impedance of the blood vessel using the implantable measurement device;
causing the control system to transmit patient information to a display, the patient information based at least in part on the blood vessel impedance; and
comparing data from the means for measuring a physiological parameter of the patient to the impedance of the blood vessel.