Versatile biodegradable elastic polymers featured with dual crosslinking mechanism for biomedical applications
The present invention provides a dual crosslinked biodegradable polymer and methods of making and using the polymer. The dual crosslinked biodegradable polymer composition includes a multifunctional monomer; a diol; and an unsaturated di-acid at least partially polymerized to form a network and photocrosslinked into a dual crosslinked polymer network.
1. A crosslinked polymer composition comprising:
a condensation reaction product of monomers consisting of citric acid; at least one diol; and at least one unsaturated di-acid, wherein the monomers are at least partially polymerized to form a network and crosslinked into a crosslinked polymer network.
2. The composition of claim 1 , wherein the diol comprises poly(ethylene glycol) and the unsaturated di-acid comprises maleic anhydride.
3. The composition of claim 1 , wherein the diol comprises saturated aliphatic diols, macrodiols, or both.
4. The composition of claim 1 , wherein the unsaturated di-acid comprises maleic acid, maleic anhydride, fumaric acid, or fumaryl chloride.
5. The composition of claim 1 , wherein the citric acid is end capped with a vinyl group from acryloyl chloride.
6. The composition of claim 1 , wherein the network comprises a polycondensation or free radical polymerization network.
7. The composition of claim 1 , further comprising one or more crosslinkers.
8. The composition of claim 1 , wherein the crosslinked polymer network forms a soft tissue selected from a blood vessel, a cardiac tissue, heart valves, a ligament, a tendon, a lung, a bladder, skin, a trachea, a urethra, micro-fibers or nano-fibers.
9. The polymer composition of claim 1 further comprising a drug covalently linked into the network through a terminal vinyl containing group.
10. The polymer composition of claim 1 , wherein available hydroxyl or carboxylic acid groups of the network are modified with an oligonucleotide, a peptide chain, or a protein.
11. The polymer composition of claim 1 , wherein available hydroxyl or carboxylic acid groups of the network are modified with collagen, laminin, or RGD.
12. The polymer composition of claim 1 further comprising an encapsulated cell.
13. A 3-D porous scaffold formed from the polymer composition of claim 1 .
14. The scaffold of claim 13 , wherein the scaffold comprises micropatterned channels inside the scaffold.
15. A composite comprising:
a polymer composition comprising the condensation reaction product of monomers consisting of citric acid, at least one diol, and at least one unsaturated di-acid, wherein the monomers are at least partially polymerized to form a network; and
an inorganic material mixed with the network.
16. The composite of claim 15 , wherein the inorganic material comprises ceramic micro-particles or nano-particles.
17. The composite of claim 15 , wherein the inorganic material comprises hydroxyapatite.
18. The composite of claim 15 , wherein the inorganic material comprises calcium phosphate.
19. The composite of claim 15 , wherein the diol comprises poly(ethylene glycol) and the unsaturated diacid comprises maleic anhydride.
20. The composite of claim 15 , wherein the network is crosslinked.