Cancer cell targeting using nanoparticles
The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
1. A nanoparticle comprising:
(a) docetaxel;
(b) a diblock copolymer of poly(ethylene glycol) and polylactic acid; and
(c) a prostate specific membrane antigen ligand conjugated to a diblock copolymer of poly(ethylene glycol) and polylactic acid, wherein the prostate specific membrane antigen ligand has the structure
2. The nanoparticle of claim 1 wherein the nanoparticle has a diameter in the range of 80 nm to 200 nm.
3. A pharmaceutical composition comprising:
(a) a plurality of nanoparticles, wherein each nanoparticle comprises:
i. docetaxel;
ii. a diblock copolymer of poly(ethylene glycol) and polylactic acid; and
iii. a PMSA ligand conjugated to a diblock copolymer of poly(ethylene glycol) and polylactic acid, wherein the PMSA ligand has the structure,
and
(b) a pharmaceutically acceptable carrier.
4. The pharmaceutical composition of claim 3 , wherein the nanoparticles have a diameter of 80 nm to 200 nm.