Granted Patent B2

US 8,610,056 · App. 13/164,617 · Granted Dec 17, 2013

Inventors: Craig M. Whitehouse (Branford, CT); Thomas Dresch (Berlin, DE); Bruce Andrien, Jr. (Guilford, CT)

Assignee: PerkinElmer Health Sciences Inc.

B01D59/44

Abstract

Claims (14)

1. An apparatus, comprising:

an atmospheric pressure ion source;

a first vacuum stage and a second vacuum stage separated from the first vacuum stage by a vacuum partition;

a first ion guide positioned within the first vacuum stage and arranged to receive ions from the atmospheric pressure ion source;

a second ion guide positioned within the second vacuum stage, the second vacuum stage being downstream of the first vacuum stage from the atmospheric pressure ion source, the second ion guide being a multipole ion guide arranged to receive ions from the first ion guide; and

a time-of-flight mass analyzer comprising an orthogonal pulsing region arranged to receive ions from the second ion guide.

2. The apparatus of claim 1 , wherein the first ion guide is a multipole ion guide.

3. The apparatus of claim 1 , further comprising one or more electrostatic lenses positioned between the second ion guide and the time-of-flight mass analyzer.

4. The apparatus of claim 1 , further comprising a third vacuum stage housing containing the time-of-flight mass analyzer.

5. The apparatus of claim 4 , wherein the third vacuum stage is adjacent to the second vacuum stage.

6. The apparatus of claim 5 , wherein the second ion guide is a quadrupole ion guide.

7. The apparatus of claim 6 , wherein the second ion guide is a hexapole ion guide.

8. The apparatus of claim 7 , wherein the time of flight mass analyzer comprises a tube, a reflector lens assembly, and a detector positioned at the opposite end of the tube from the reflector lens assembly.

9. The apparatus of claim 8 , wherein the orthogonal pulsing region and the detector are positioned at the same end of the tube.

Assignments (2)

Continuity (15)