IP Library › Granted Patent US 8,618,077
Granted Patent B2
US 8,618,077 · App. 13/457,718 · Granted Dec 31, 2013

Compositions and methods for treating fragile X premutation RVGG repeats-mediated toxicity

Inventors: Peng Jin (Decatur, GA); Abrar Qurashi (Decatur, GA)
Assignee: Emory University
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Quick Facts
Patent No.
US 8,618,077
App. No.
13/457,718
Granted
Dec 31, 2013
Kind
B2
Abstract

Compositions and methods of treatment or prophylaxis of fragile-X associated disorders are provided, as well as methods of screening compounds and kits to screen a library of compounds.

Claims (3)

1. A method of treating a fragile X-associated disorder comprising administering an effective amount of a compound selected from xylazine, 4′-methoxychalcone, 5 fluoroindole-2-carboxylic acid, propachlor, furegrelate, asarylaldehyde, chromocarb, acetyltryptophanamide, salts, esters, and prodrugs thereof to a subject in need thereof.

2. The method of claim 1 , wherein the subject is diagnosed with a permutation CGG allele.

3. The method of claim 1 , wherein the subject is diagnosed with fragile X-associated tremor and ataxia syndrome.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 11, 2012
From: JIN, PENG; QURASHI, ABRARA
To: EMORY UNIVERSITY
Reel/Frame 028192/0782 →
Continuity (2)
Provisional Application 61479968 · Apr 28, 2011
Related Publication 20120277178A1 · Nov 1, 2012